Ofloxacin ophthalmic solution

Surgeries were performed using a VisuMax (Carl Zeiss Meditec) femtosecond laser platform by one experienced surgeon. Before surgery, 0.5% proparacaine hydrochloride (Alcon-couvreur N. V, Belgium) was used for anaesthesia. The suction time was 23 s for lenticule creation. The angle of the lenticule side cut was 90°. The cap depth was 120 μm with a diameter of 7.5 mm and a side cut angle of 120°. After the surgery, topical steroids (fluorometholone 0.1%; Santen Pharmaceutical Co., Ltd.) was used 6 times a day and reduced every 5–7 days over 30 days. Topical antibiotics (ofloxacin ophthalmic solution 0.5%; Santen Pharmaceutical Co., Ltd.) was used 4 times a day for 14 days. Artificial tears (sodium hyaluronate 0.1%, Santen Pharmaceutical Co., Ltd.) was used 4 times a day for at least 1 month.

A VisuMax (Carl Zeiss Meditec) femtosecond laser platform was used for all surgical procedures. Surgery was performed as described by a previous study and was done by the same experienced surgeon [18 (link)]. The suction time lasted for 24 seconds during the lenticule creation. Postoperatively, in addition to the regular topical antibiotics (ofloxacin ophthalmic solution 0.5%; Santen Pharmaceutical Co., Ltd.) and artificial tears (sodium hyaluronate eye drops 0.3%; Santen Pharmaceutical Co., Ltd.), topical steroids (fluorometholone 0.1%; Santen Pharmaceutical Co., Ltd.) were initially administered 6 times a day and tapered off over 20 days.

Patients were instructed to wear the bandage soft contact lens for 1 week. Topical steroids (fluorometholone 0.1%; Santen Pharmaceutical Co., Ltd.) were initially administered 8 times/day and tapered over 75 days. Topical antibiotics (ofloxacin ophthalmic solution 0.5%; Santen Pharmaceutical Co., Ltd.) were administered 4 times/day for 7 days. Tears Naturale (hypromellose 2910, dextran 70, glycerol eye drops; Alcon Laboratories, Inc.) were administered 4 times/day for 3 months.
Patients were followed-up at postoperative 1 day, 1 week, 1, 3 and 6 months. All subsequent follow-up visits recorded uncorrected distance visual acuity (UDVA), CDVA, manifest refraction, corneal topography, and corneal aberrations. All postoperative examinations were conducted by the same experienced optometrists.