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Polyi polyc pi pc

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PolyI–polyC (pI-pC) is a synthetic double-stranded RNA (dsRNA) molecule. It is composed of polyinosinic acid (polyI) and polycytidylic acid (polyC), which are paired together to form a dsRNA structure. This synthetic dsRNA can be used as a research tool in various experimental settings.

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Lab products found in correlation

Hemavet 950fs, by Drew Scientific (2 mentions)

Spelling variants of this product

PolyI:polyC (3 citations)

2 protocols using polyi polyc pi pc

1

Conditional Deletion of Foxm1 In Vivo

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For conditional deletion of Foxm1 in vivo, Foxm1fl/fl mice were mated to Tie2-Cre or Mx1-Cre transgenic mice to generate Foxm1fl/flTie2-Cre or Foxm1fl/flMx1-Cre mice. Mx1-Cre expression was induced by 3 intraperitoneal (i.p.) injections of 6–10 μg polyI–polyC (pI-pC) (GE Healthcare) per gram of body weight every second day for a total of three injections. Times after pI-pC injection are counted from the third pI-pC injection. Peripheral blood samples were collected by tail bleeding into tubes containing EDTA. Complete blood counts and differentials were obtained using a Hemavet 950FS (Drew Scientific). All animal research was approved by the University of Illinois at Chicago Institutional Animal Care and Use Committee.
Hou Y., Li W., Sheng Y., Li L., Huang Y., Zhang Z., Zhu T., Peace D., Quigley J.G., Wu W., Zhao Y, & Qian Z. (2015). Foxm1 is essential for quiescence and maintenance of hematopoietic stem cells. Nature immunology, 16(8), 810-818.
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2

Conditional Deletion of Foxm1 In Vivo

Check if the same lab product or an alternative is used in the 5 most similar protocols
For conditional deletion of Foxm1 in vivo, Foxm1fl/fl mice were mated to Tie2-Cre or Mx1-Cre transgenic mice to generate Foxm1fl/flTie2-Cre or Foxm1fl/flMx1-Cre mice. Mx1-Cre expression was induced by 3 intraperitoneal (i.p.) injections of 6–10 μg polyI–polyC (pI-pC) (GE Healthcare) per gram of body weight every second day for a total of three injections. Times after pI-pC injection are counted from the third pI-pC injection. Peripheral blood samples were collected by tail bleeding into tubes containing EDTA. Complete blood counts and differentials were obtained using a Hemavet 950FS (Drew Scientific). All animal research was approved by the University of Illinois at Chicago Institutional Animal Care and Use Committee.
Hou Y., Li W., Sheng Y., Li L., Huang Y., Zhang Z., Zhu T., Peace D., Quigley J.G., Wu W., Zhao Y, & Qian Z. (2015). Foxm1 is essential for quiescence and maintenance of hematopoietic stem cells. Nature immunology, 16(8), 810-818.
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