Harmonic

Manufactured by Johnson & Johnson

Sourced in United States

Harmonic is a laboratory equipment product that utilizes ultrasonic technology to facilitate various procedures. It is designed to perform tasks such as tissue disruption, cell lysis, and sample preparation. The core function of Harmonic is to provide a reliable and efficient tool for researchers and laboratory professionals to optimize their experimental workflows.

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Lab products found in correlation

Ligasure, by Medtronic (2 mentions) Enseal, by Johnson & Johnson (1 mentions) Single site, by Intuitive Surgical (1 mentions) Maryland bipolar forceps, by Intuitive Surgical (1 mentions)

Spelling variants of this product

Harmonic scalpel (43 citations) Harmonic Ace (9 citations) Harmonic Blade (6 citations) Harmonic Focus (4 citations) Ultrasonic harmonic scalpel (3 citations) Harmonic shears (2 citations) Harmonic ACE® + 7 Shears (2 citations) Ultracision harmonic scalpel (2 citations) Harmonic Ace Curved Dissector (2 citations) Harmonic Ace +7 (2 citations)

4 protocols using harmonic

Standardized Laparoscopic Distal Gastrectomy Protocol

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LDG was performed by 10 surgeons, including 3 who were board-certified by the Japanese Society of Endoscopic Surgery. Surgical procedures were standardized for LDG and have been described in detail elsewhere [25 (link)–27 (link)]. LDG was performed using an ABD (LigaSure™; Medtronic plc, Dublin, Ireland, or Enseal®; Ethicon Endo-Surgery, Cincinnati, OH, USA) or USAD (Harmonic®; Ethicon Endo-Surgery or Sonicision™; Medtronic plc) as the main energy device for dissection, at each surgeon’s preference.
Most of the surgical procedures using ABD were similar to those using USAD, except for the clipless sealing procedure of certain small-caliber vessels. Intracorporal Billroth I reconstruction with functional end-to-end anastomosis or Roux-en-Y reconstruction was performed following distal gastrectomy [28 (link), 29 (link)]. A portable drain was routinely inserted at the upper border of the pancreas.

Shibao K., Honda S., Adachi Y., Kohi S., Kudou Y., Matayoshi N., Sato N, & Hirata K. (2022). An advanced bipolar device helps reduce the rate of postoperative pancreatic fistula in laparoscopic gastrectomy for gastric cancer patients: a propensity score-matched analysis. Langenbeck's Archives of Surgery, 407(8), 3479-3486.

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Reduced-Port Robotic Gastrectomy Technique

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Details on the procedure for reduced-port robotic gastrectomy at our institution have been previously published [9 (link)10 (link)]. The port placements for total or proximal gastrectomy are similar to those for reduced-port robotic distal gastrectomy. The reduced-port approach used a Single-Site^® (Intuitive Surgical, Sunnyvale, CA, USA) below the umbilicus and two additional ports for rigid instruments on both sides of the abdomen. An infra-umbilical 25 mm vertical incision was made, and a Single-Site^® was inserted. An 8.5-mm camera port, a 10-mm assistant port, and a 5-mm curved cannula for semi-rigid Cadiere forceps (Intuitive Surgical) was inserted via the Single-Site^®. An 8-mm cannula was placed on the right upper abdomen for ultrasonic shears (Harmonic^®, Ethicon Endo-surgery, Cincinnati, OH, USA), with another 8-mm cannula on the left lower abdomen for Maryland bipolar forceps (Intuitive Surgical). The two ports were placed in a port-in-port fashion via 12-mm laparoscopic balloon ports (Kii Balloon Blunt Tip System, Applied Medical, Rancho Santa Margarita, CA, USA), which were used to access the endolinear stapler during anastomosis.

Choi S., Son T., Song J.H., Lee S., Cho M., Kim Y.M., Kim H.I, & Hyung W.J. (2021). Intracorporeal Esophagojejunostomy during Reduced-port Totally Robotic Gastrectomy for Proximal Gastric Cancer: a Novel Application of the Single-Site® Plus 2-port System. Journal of Gastric Cancer, 21(2), 132-141.

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Minimally Invasive Liver Tumor Resection

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The patient was placed in a supine position, and the “five-hole” approach for trocar placement (Fig. 1a, b) consisted of two 5-mm and three additional 12-mm trocars. Carbon dioxide pneumoperitoneum was established at a pressure of 12–15 mmHg. The central venous pressure was maintained below 5-mm H₂O. After opening the lesser omental sac using a Harmonic scalpel (Harmonic, Ethicon), the procedure was initiated.Fig. 1

a Trocar’s location during resection of the left liver tumor. b Trocar’s location during resection of the right liver tumor

Zhou Y., Wang Y., Ma J, & Zhang C. (2023). “Hooking method” for hepatic inflow control: a new approach for laparoscopic Pringle maneuver. World Journal of Surgical Oncology, 21, 254.

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Vibrating Dissection Device for Minimally Invasive Surgery

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The DD1 has a plastic tip made of polyetheretherketone (PEEK) that rapidly vibrates to mechanically tease tissues apart. (Figure 1) Vibration is driven by a motor and batteries that are in the handle, making the device cordless. A control knob in the handle adjusts the vibration speed. The surgeon controls dissection by determining the point of application of the vibrating tip, the speed of vibration, the force with which the tip is pushed into the tissue plane, and the force of countertraction.
Three different types of experiments were conducted on live, anaesthetized pigs: First, tissue trauma arising from transient contact with a variety of different tissues was evaluated for two devices: DD1 and electric scalpel (ES); Second, thermal measurements were made for four devices (DD1, ES, Harmonic (Ethicon, USA), and LigaSure (Covidien, Ireland)) via thermal videography. Third, the speed of dissection was compared between the DD1 and manual forceps for mobilizing the mesentery arteries of the small intestine. In our experience, 50% power setting (middle vibration speed) is suitable for most tissues. Additionally, the DD1 works best when the tissues are moist, so moistening the surface with saline permits more delicate dissection while also reducing the risk of desiccation.

Yoshida N., Yamazaki S., Sugitani M, & Takayama T. (2018). Safety and feasibility of a novel non-thermal device for tissue dissection: A preliminary study of the DD1 differential dissector. Bioscience trends, 12(1).

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