Ge lunar prodigy dxa

In vivo body composition of the rats was assessed using the GE Lunar Prodigy DXA with Small Animal Software (GE, Madison, WI; v.6.10) as previously described and validated (Moreau et al., 2001 (link); Bertin et al., 1998 (link)). The rats were anesthetized with a constant flow of 4% isoflurane in oxygen. They were then placed in a prostrated position on the DXA and scanned using the Small Animal Software (v.6.10). Each scan took ∼5 min and the resulting data were analyzed by drawing a region of interest that included the entire rat. Data obtained from this scan included total body fat mass, lean mass, BMD and BMC.

DXA scans were performed using either GE Lunar Prodigy DXA (software version 13.2; GE Healthcare) in Birmingham, Cambridge, and Hull or Hologic Discovery/W DXA (Apex software version 3.0; Hologic Inc) in Sheffield. All scans were acquired and analyzed according to each manufacturer's standard scanning and positioning protocols. TB BMD and FM were measured, together with L1 and total-hip BMD. Known differences in calibration exist between Hologic and GE for all scan types (36 , 40 (link)). For lumbar spine and hip scans, systematic bias was limited by converting all measures to standardized BMD (38 (link), 39 ). For TB, systematic differences were limited using cross-calibration equations for all bone and soft tissue regions of interest (40 (link)). Full details have previously been reported, including quality control checks and grading of TB scans for metallic artifacts (28 (link)). Because only 330 (59.5%) of the original multicenter study population (29 (link)) had TB DXA scans performed, the principal characteristics of individuals who received a TB DXA scan were compared with those who did not. No differences were observed in weight, height, sex, age, or ethnicity (data not shown).