Zyprexa® tablets 2.5 mg (containing 2.5 mg olanzapine) were purchased from Eli Lilly Japan K. K. (Hyogo, Japan). Witepsol H-15, S-5, and E-75 suppository molds (2.25 cm3) were purchased from Maruishi Pharmaceutical Co., Ltd. (Osaka, Japan). olanzapine, perchloric acid (60 %), 10 % ammonia solution, dipotassium hydrogen phosphate, and 1 mol/L potassium hydroxide solution were purchased from Wako Pure Chemical Industries, Ltd. (Osaka, Japan). Tetramethylammonium perchlorate was purchased from Tokyo Chemical Industry Co., Ltd. (Tokyo, Japan). Potassium dihydrogen phosphate and acetonitrile were purchased from Nacalai Tesque, Inc. (Kyoto, Japan).
Olanzapine
Manufactured by Eli Lilly
Sourced in United States
Olanzapine is a laboratory product manufactured by Eli Lilly. It is a chemical compound used in various research and scientific applications.
Automatically generated - may contain errors
Lab products found in correlation
Dipotassium hydrogen phosphate, by Fujifilm (1 mentions)
Olanzapine, by Fujifilm (1 mentions)
Potassium dihydrogen phosphate, by Nacalai Tesque (1 mentions)
Acetonitrile, by Nacalai Tesque (1 mentions)
Haloperidol, by Merck Group (1 mentions)
Zyprexa, by Eli Lilly (1 mentions)
Bicuculline methiodide, by Merck Group (1 mentions)
Haloperidol, by Johnson & Johnson (1 mentions)
4 pba, by Merck Group (1 mentions)
Formic acid, by Fujifilm (1 mentions)
Ammonium formate, by Fujifilm (1 mentions)
D glucose, by Fujifilm (1 mentions)
Diazepam, by Fujifilm (1 mentions)
Lc ms grade methanol, by Kanto Chemical (1 mentions)
Olanzapine, by AK Scientific (1 mentions)
Acetonitrile, by Kanto Chemical (1 mentions)
10 protocols using olanzapine
1
Olanzapine Tablet and Suppository Formulations
2
Antipsychotic Drugs in Mouse EAE Model
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Female C57BL/6 mice were purchased from the Malaghan Institute (Wellington, New Zealand) and used between 8 and 12 weeks of age. Food and water were available ad libitum, and all experimental procedures were approved by the VUW Animal Ethics Committee (approval 2008-R12 and 2014-R23). Clozapine, risperidone, and quetiapine were kindly supplied by Douglas Pharmaceuticals Ltd. (Auckland, New Zealand) and olanzapine by Eli Lilly and Company (NZ) Ltd. (Auckland, New Zealand). Clozapine, risperidone, and quetiapine were dissolved in 0.1 M acetic acid at a concentration of 6 mg/mL before dilution in drinking water to deliver the doses indicated in the figure text to healthy mice or mice with EAE. olanzapine, due to its insolubility, was mixed with ground feed and reformed into pellets to deliver 3 mg/kg/day. Mice treated with glatiramer acetate (GA; Teva Pharmaceutical Industries Ltd., Petach Tikva, Israel) received 100 and 500 µg/mouse in the MOG/CFA emulsion on day 0 as described.15 (link) Daily water or food consumption was recorded to ensure correct dosing, and all treatments were maintained until euthanasia.
3
Olanzapine for Neuropathic Pain Relief
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In the first stage of the study, groups of rats were injected intraperitoneally with Olanzapine (10 mg/kg) or normal saline (10 ml/kg) to investigate the pre-treatment effect of the drug in preventing allodynia.
Twenty-two rats were divided into 3 groups: a sham group (n = 6), a normal saline group (n = 8), and the Olanzapine group (n = 8). The Olanzapine group rats were injected intraperitoneally with 10 mg/kg Olanzapine 1 h before the surgery. Olanzapine (Eli Lilly and Company, Indianapolis, IN) was dissolved in normal saline (1 mg/ml). The sham and normal saline group rats were injected intraperitoneally with normal saline (10 ml/kg) 1 h before the surgery. The dosage of Olanzapine used in the present study was based on a previous report, in which an injection of 10 mg/kg showed the maximum antinociceptive effect in the mouse tail-flick assay [9 (link)]. Mechanical allodynia was measured before and 7 days after the surgery. Each animal was sacrificed for Iba-1 immunohistochemical analysis after the last behavioural study.
Twenty-two rats were divided into 3 groups: a sham group (n = 6), a normal saline group (n = 8), and the Olanzapine group (n = 8). The Olanzapine group rats were injected intraperitoneally with 10 mg/kg Olanzapine 1 h before the surgery. Olanzapine (Eli Lilly and Company, Indianapolis, IN) was dissolved in normal saline (1 mg/ml). The sham and normal saline group rats were injected intraperitoneally with normal saline (10 ml/kg) 1 h before the surgery. The dosage of Olanzapine used in the present study was based on a previous report, in which an injection of 10 mg/kg showed the maximum antinociceptive effect in the mouse tail-flick assay [9 (link)]. Mechanical allodynia was measured before and 7 days after the surgery. Each animal was sacrificed for Iba-1 immunohistochemical analysis after the last behavioural study.
4
Pharmacokinetic Profiles of Psychoactive Compounds
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TAK‐063 was synthesized by Takeda Pharmaceutical Company Limited. Haloperidol was purchased from Sigma‐Aldrich Co. LLC. (St. Louis, MO). Olanzapine was extracted from Zyprexa® (Eli Lilly and Company, Indianapolis, IN) at KNC Laboratories Co. Ltd. (Kobe, Japan) or purchased from AK Scientific Inc. (Union City, CA). Aripiprazole was purchased from AK Scientific Inc. TAK‐063 and Haloperidol were suspended in 0.5% (w/v) methylcellulose in distilled water and administered orally (p.o.). Olanzapine was dissolved in 1.5% (v/v) lactic acid. The pH of this solution was then adjusted to neutral using 1 mol L−1 NaOH and administered orally. Aripiprazole was suspended in a 1% (v/v) solution of Tween 80 in distilled water and administered orally. Methamphetamine hydrochloride (METH, Dainippon Sumitomo Pharma Co. Ltd., Osaka, Japan) and (+)‐MK‐801 hydrogen maleate (MK‐801, Sigma‐Aldrich) were dissolved in saline and administered subcutaneously (s.c.). All compounds were dosed at 20 and 2 mL/kg body weight in mice and rats, respectively.
5
Olanzapine and Metformin in Mice
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Olanzapine (brand name: Zyprexa) was purchased from Eli Lilly, United States. Metformin hydrochloride was obtained from Hunan Xiangya Pharmaceutical Co., Ltd., Changsha, China. Olanzapine was dissolved in 0.9% saline solution and maintained in one gavage administration (4 mg/kg/day) every day for 8 weeks. Olanzapine (4 mg/kg/day, oral) and metformin hydrochloride (150 mg/kg/day, oral) were prepared as previously (Matsui et al., 2010 (link); Savoy et al., 2010 (link)). The vehicle solution for metformin was 0.9% saline solution. All the drugs were prepared freshly prior to usage and administered orally (gastric gavage) between 9:00 and 14:00 h every day.
6
Chronic Antipsychotic Effects on Neural Network Development
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To model the chronic administration of antipsychotics in patients, 100 nM olanzapine (Eli Lilly and Co) and 100 nM haloperidol (Janssen) were added on day 3, 11 and 19 of cultivation, dissolved in minimal Eagle’s medium (MEM). At these time points, half of the cultivation medium was replaced with fresh medium containing the double concentration of the drug. In the control condition, an equal volume of pure MEM was added. The continuous replenishment of the drug pool aimed to compensate for the activity dependent usage47 (link) and allowed us to examine their effects during the early, premature and mature stages of neural network development in our setup25 (link), 50 , 51 (link). The final concentrations of drugs were selected on the basis of the target concentration range of antipsychotics in patients’ blood plasma29 (link), the target receptor affinity, and preliminary survival tests (see Supplementary Fig. S1d ). To reveal the contribution of GABAergic signaling, 6 µM bicuculline methiodide (Sigma-Aldrich, #14343) was bath applied for 30 minutes prior to measurement.
7
Double-Blind Randomized Olanzapine Trial
8
LPS and Olanzapine Administration in Animal Model
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LPS from Escherichia coli strain 0111:B4 (L2630; Sigma-Aldrich, St. Louis, MO, USA) [17 (link)] and olanzapine (Eli Lilly & Company, Indianapolis, IN, USA) were administered intraperitoneally just before closing the laparotomy. LPS and olanzapine were dissolved in 0.9% NaCl (pH 7.4) and administered in volumes of 0.5 ml/kg and 1 ml/kg, respectively.
9
Sprague-Dawley Rat ER Stress Study
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Female Sprague–Dawley (SD) rats (10 weeks) were purchased from the Animal Resources Center [SPF (Beijing) Biot Co., Ltd., Beijing, China]. The rats were kept in a 12-h light–dark cycle and lights on 0700 h. The temperature was 22 ± 2°C. Throughout the studies, the rats were fed a standard diet. All the animal studies were approved by the Ethics Committee of Wuhan University of Technology. The ER stress inhibitor 4-PBA was purchased from Sigma-Aldrich (#p21005). Olanzapine was purchased from Eli Lilly, Indianapolis, IN, United States.
10
Olanzapine Administration in Diet-Induced Obesity
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Olanzapine (Zyprexa) was purchased from Eli Lilly Corporation (Indianapolis, IN, USA). Olanzapine (# I960) was purchased from Ak-Scientific (Union City, CA, USA). Zyprexa was used for intraperitoneal (i.p.) administration. Olanzapine (# I960) was used for mixing into the diet. Normal diet (ND; F-2) was purchased from Sankyo Lab Service Corporation (Tokyo, Japan). High-fat diet (HFD; D12492M, 60 kcal% fat) was purchased from Research Diets (New Brunswick, NJ, USA). D-glucose, diazepam, formic acid, and ammonium formate were purchased from Wako Pure Chemicals (Osaka, Japan). LC-MS grade methanol and acetonitrile were purchased from Kanto Chemical Co., Inc. (Tokyo, Japan). Bond Elut QuEChERS extract pouches were purchased from Agilent Technologies (Santa Clara, CA, USA). All other reagents used were of the highest grade and commercially available.
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