Fluvastatin sodium

Manufactured by Selleck Chemicals

Fluvastatin sodium is a synthetic compound used in the laboratory as a chemical standard. It is a crystalline powder and the sodium salt of the statin drug fluvastatin. Fluvastatin sodium is commonly used in analytical and research applications to identify and quantify fluvastatin in various samples.

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3 protocols using fluvastatin sodium

Statins Overcome Erlotinib Resistance in NSCLC

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Experiments were carried out with human lung adenocarcinoma cell lines A549 (ATCC CCL_185), Calu6 (ATCC HTB-56) and NCI-H1993 (ATCC CRL-5909). All cell lines were obtained from American Type Cell Culture Collection (ATCC) and cultured in DMEM growth medium (GIBCO #31966-21), supplemented with 10% heat-inactivated foetal bovine serum (FBS) and 1% antibiotics (penicillin, streptomycin). Cells were kept at 37 °C and 5% CO₂ in the incubator and were passaged at 80–90% confluence every 2–3 days to maintain continuous logarithmic growth. All cell lines studied in this work were erlotinib resistant and EGFR wild type (Table 1). Cells were treated with pitavastatin calcium (SelleckChem, #S1759), fluvastatin sodium (SelleckChem, #S1909) and erlotinib hydrochloride (SelleckChem, #S1023).Table 1

Human NSCLC cell lines harbouring different genetic mutations examined in the study.

Cell line	EGFR	K-Ras	Met	p53	Erlotinib
A549	Wildtype	Mutated	Wildtype	Wildtype	Resistant
Calu6	Wildtype	Mutated	Wildtype	Mutated	Resistant
H1993	Wildtype	Wildtype	Amplified	Mutated	Resistant

Otahal A., Aydemir D., Tomasich E, & Minichsdorfer C. (2020). Delineation of cell death mechanisms induced by synergistic effects of statins and erlotinib in non-small cell lung cancer cell (NSCLC) lines. Scientific Reports, 10, 959.

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Comprehensive Analytical Reagents Protocol

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Water (LC-MS Grade, Optima; 10509404), Acetonitrile (LC-MS Grade, Optima; 10001334), Methanol (LC-MS Grade, Optima, A456-212) and Formic acid (LC-MS Grade, Thermo Scientific Pierce; 13454279) were purchased from Fisher Chemicals. Human cell lysate (MS Compatible Human Protein Extract, Digest, V6951) and Trypsin (Sequence grade, V511X) were purchased from Promega. DL-Dithiothreitol (BioUltra, 43815), Iodoacetamide (BioUltra, I1149) Ammonium Bicarbonate (Eluent additive for LC-MS, 40867), Yeast Nitrogen Base Without Amino Acids (Y0626) and glass beads (acid washed, 425-600 µm, Sigma, G8772) were purchased from Sigma Aldrich. Urea (puriss. P.a., reag. Ph. Eur., 33247H) and Acetic Acid (Eluent additive for LC-MS, 49199) were purchased from Honeywell Research Chemicals. Rosuvastatin Calcium (S2169), Fluvastatin Sodium (S1909), Pyrimethamine (S2006), Pitavastatin Calcium (S1759), Pemetrexed Disodium Hydrate (S7785), Pravastatin Sodium (S3036), Clotrimazole (S1606), Miconazole Nitrate (S1956), Lovastatin (S2061), Ketoconazole (S1353), Atorvastatin (S2077), Methotrexate Disodium (S5097), Simvastatin (S1792), Uniconazole (S3660), Itraconazole (S2476) were purchased from Selleck chemicals and Pralatrexate (A4350) was purchased from APExBIO. Control samples for SARS-CoV-2 study were prepared from commercial Human Plasma (EDTA, Pooled Donor, Genetex GTX73265).

Messner C.B., Demichev V., Bloomfield N., Yu J.S., White M., Kreidl M., Egger A.S., Freiwald A., Ivosev G., Wasim F., Zelezniak A., Jürgens L., Suttorp N., Sander L.E., Kurth F., Lilley K.S., Mülleder M., Tate S, & Ralser M. (2021). Ultra-fast proteomics with Scanning SWATH. Nature biotechnology, 39(7), 846-854.

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Cholesterol Biosynthesis Pathway Modulators

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We purchased Pitavastatin Calcium (S1759), Fluvastatin sodium (S1909), ABT-199 (S0848), and CHIR-98014 (S2745) from Selleckchem. We purchased cholesterol (S5442), mevalonolactone (M4667), and coenzyme Q₁₀ (C9538) from Sigma-Aldrich. We purchased YM-53601 (18113), farnesyl pyrophosphate ammonium salt (63250) and geranylgeranyl pyrophosphate ammonium salt (63330) from Cayman Chemical.

Rashkovan M., Albero R., Gianni F., Perez-Duran P., Miller H.I., Mackey A.L., Paietta E.M., Tallman M.S., Rowe J.M., Litzow M.R., Wiernik P.H., Luger S., Sulis M.L., Soni R.K, & Ferrando A.A. (2022). Intracellular cholesterol pools regulate oncogenic signaling and epigenetic circuitries in Early T-cell Precursor Acute Lymphoblastic Leukemia. Cancer discovery, 12(3), 856-871.

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