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3h pitavastatin

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[3H]-Pitavastatin is a radiolabeled compound that contains the pharmaceutical agent pitavastatin, which is a synthetic statin drug. It is labeled with the radioactive isotope tritium (3H). [3H]-Pitavastatin is primarily used as a research tool for studies related to the pharmacokinetics, biodistribution, and metabolism of pitavastatin.

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2 protocols using 3h pitavastatin

1

Radiolabeled Compound Procurement for Research

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Allopurinol, oxypurinol, mitoxantrone, and Ko-143 were purchased from Sigma-Aldrich (St. Louis, MO). [3H]-Allopurinol was purchased from Moravek Biochemicals (Brea, CA), [3H]-oxypurinol was custom-synthesized by tritiation performed by IsoSciences (King of Prussia, PA), and [3H]-Pitavastatin was purchased from American Radiolabeled Chemicals (St. Louis, MO). Cell culture medium, Hank’s Balanced Salt Solution (HBSS), fetal bovine serum (FBS), penicillin/streptomycin, and glutamine were purchased from University of California San Francisco Cell Culture Facility (San Francisco, CA).
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2

Characterization of Radiolabeled Compounds

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[ 3 H]cholecystokinin 8 (CCK-8) (specific activity 98.7.0 Ci/mmol) was purchased from Perkin Elmer Life Science (Waltham, MA). [ 3 H]Pitavastatin (specific activity 5 Ci/mmol), unlabeled pitavastatin and [ 3 H]rosuvastatin (specific activity 20 Ci/mmol) were purchased from American Radiolabeled Chemicals (St. Louis, MO). Unlabeled rosuvastatin was purchased from Toronto Research Chemicals, Inc. (North York, ON, Canada). EVR, SIR, and dasatinib were purchased from LC laboratories (Woburn, MA). Unlabeled CCK-8, bromosulfophtalein (BSP), rifampicin, and Dulbecco's Modified Eagle Medium (DMEM) were purchased from Sigma-Aldrich (St. Louis, MO). Fetal bovine serum (FBS) was purchased from Hyclone Laboratories (Logan, Utah). Bio-Safe II liquid scintillation mixture was purchased from Research Products International (Mt. Prospect, IL). All other materials were purchased from Thermo Fisher Scientific (Waltham, MA), Sigma-Aldrich (St. Louis, MO), or VWR International (Radnor, PA).
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