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Vistusertib

Manufactured by AstraZeneca
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Vistusertib is a laboratory equipment product. It is a small molecule that functions as a kinase inhibitor.

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Lab products found in correlation

Alectinib, by Selleck Chemicals (1 mentions) Erdafitinib, by Selleck Chemicals (1 mentions) Lorlatinib, by Selleck Chemicals (1 mentions) Entrectinib, by Selleck Chemicals (1 mentions) Podoplanin, by Agilent Technologies (1 mentions) Brigatinib, by Selleck Chemicals (1 mentions) Dasatinib, by Selleck Chemicals (1 mentions) Crizotinib, by Selleck Chemicals (1 mentions) Beta catenin, by Agilent Technologies (1 mentions) Vimentin, by Roche (1 mentions) P mapk, by Cell Signaling Technology (1 mentions) Debio1347, by Selleck Chemicals (1 mentions) Saracatinib, by AstraZeneca (1 mentions) Vimentin, by Cell Signaling Technology (1 mentions) Paclitaxel, by Merck Group (1 mentions)

2 protocols using vistusertib

1

Comprehensive Oncology Protein Analysis

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Saracatinib (AZD0530) and vistusertib (AZD2014) were provided by AstraZeneca. Crizotinib (S1068), alectinib (S2762), brigatinib (S8229), dasatinib (S1021), erdafitinib (S8401), debio-1347 (S7665), lorlatinib (S7536) and entrectinib (S7998) were purchased from Selleck Chemicals.
For Western Blot assays the antibodies used were: pALK Y1282/1283 (9687S), pALK Y1604 (3341S), ALK (#3333S), pAKT (#4060S), AKT (#4961S), pERK (9101S), ERK (9102S), pS6 (4858S), S6 (2217S), cleaved Parp (9541S), BIM (2933S), Merlin (1288S), pPaxillin (2541S), Paxillin (2542S), Snail (3879S) and Vimentin (5741S) purchased from Cell Signaling Technology.
For IHC assays the antibodies used were ALK (#6679072001), E-Cadh (#790-4497) and CD31 (#760-4378) purchased from Ventana; N-Cadh (#M3613), Ki-67 (#M7240), beta catenin (#M3539), podoplanin (#M3619) and CD68 (#M0814) purchased from DAKO; Vimentin (#790-2917) purchased from Roche; pSRC (#6943S) and pMAPK (#4376) purchased from Cell Signaling Technology; Glut1 (#RP128-05) purchased from Clinisciences; CA-IX (#NB100-417SS) purchased from NovusBio, NF2/Merlin purchased from Sigma-aldrich (#HPA003097) and CD47 (#M5792) purchased from Spring.
Recondo G., Mezquita L., Facchinetti F., Planchard D., Gazzah A., Bigot L., Rizvi A.Z., Frias R.L., Thiery J.P., Scoazec J.Y., Sourisseau T., Howarth K., Deas O., Samofalova D., Galissant J., Tesson P., Braye F., Naltet C., Lavaud P., Mahjoubi L., Abou Lovergne A., Vassal G., Bahleda R., Hollebecque A., Nicotra C., Ngo-Camus M., Michiels S., Lacroix L., Richon C., Auger N., De Baere T., Tselikas L., Solary E., Angevin E., Eggermont A., André F., Massard C., Olaussen K.A., Soria J.C., Besse B, & Friboulet L. (2019). Diverse resistance mechanisms to the third-generation ALK inhibitor lorlatinib in ALK-rearranged lung cancer. Clinical cancer research : an official journal of the American Association for Cancer Research, 26(1), 242-255.
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2

Cell Line Validation for Cancer Research

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All cell lines were obtained from ATCC, Teddington, UK or were available in labs within The Institute of Cancer Research, London, UK and short tandem repeat typed. Paclitaxel was purchased from Sigma and vistusertib was provided by AstraZeneca.
Wong Te Fong A.C., Thavasu P., Gagrica S., Swales K.E., Leach M.O., Cosulich S.C., Chung Y.L, & Banerji U. (2017). Evaluation of the combination of the dual m-TORC1/2 inhibitor vistusertib (AZD2014) and paclitaxel in ovarian cancer models. Oncotarget, 8(69), 113874-113884.
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