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Ropinirole hydrochloride

Manufactured by Merck Group
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Sourced in Sweden

Ropinirole hydrochloride is a chemical compound used in the production of pharmaceutical products. It is a synthetic dopamine agonist that acts on the D2 and D3 dopamine receptors. This compound is commonly used as an active ingredient in the treatment of Parkinson's disease and restless leg syndrome.

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Lab products found in correlation

Fluoxetine hydrochloride, by Merck Group (1 mentions) Clozapine, by Merck Group (1 mentions) Forskolin, by Bio-Techne (1 mentions) Pramipexole dihydrochloride, by Merck Group (1 mentions) Rotigotine hydrochloride, by Merck Group (1 mentions) Spiperone, by Merck Group (1 mentions) Quinpirole dihydrochloride, by Merck Group (1 mentions) 3 isobutyl 1 methylxanthine, by Merck Group (1 mentions) Dopamine hydrochloride, by Merck Group (1 mentions)

Close spelling variants of this product

Ropinirole Hydrochlorides

2 protocols using ropinirole hydrochloride

1

Monoamine Manipulation in Experimental Males

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Manipulations of both monoamine systems were based on concentrations found in the literature. Manipulation of the dopaminergic system was done using ropinirole hydrochloride (Sigma-Adrich, Sweden) diluted in phosphate-buffered saline (PBS) to a 33 µM concentration36 (link). Manipulation of the serotonergic system was done using fluoxetine hydrochloride (Sigma-Aldrich, Sweden) diluted to 10 μM in PBS e.g.15 (link). All experimental males (N = 144) were injected by a single experimenter (LG) and received 10 µl injected between the 4–5th segment of the abdominal cavity using a micro-syringe (Hamilton, Switzerland)29 (link). Experiments were run in two blocks, a dopamine group (dopamine manipulated individuals versus control individuals) followed by a serotonin group (serotonin manipulated individuals versus control individuals). All groups had 36 individuals. All control individuals were sham injected with 10 µl PBS.
Abbey-Lee R.N., Uhrig E.J., Garnham L., Lundgren K., Child S, & Løvlie H. (2018). Experimental manipulation of monoamine levels alters personality in crickets. Scientific Reports, 8, 16211.
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2

Pharmacological Compounds Utilized in Research

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The following compounds were purchased from Sigma-Aldrich (St. Louis, MO): dopamine hydrochloride, (±) quinpirole dihydrochloride, pramipexole dihydrochloride, ropinirole hydrochloride, rotigotine hydrochloride, clozapine, spiperone and 3-isobutyl-1-methylxanthine (IBMX). Aripiprazole was purchased from Santa Cruz Biotechnology (Dallas, TX). Forskolin was purchased from Tocris (Ellisville, MO). Haloperidol was a gift from D. Nichols, Purdue University.
Brust T.F., Hayes M.P., Roman D.L, & Watts V.J. (2014). New functional activity of aripiprazole revealed: robust antagonism of D2 dopamine receptor-stimulated Gβγ signaling. Biochemical pharmacology, 93(1), 85-91.
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