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Mda mb 468 human breast cancer cell line

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The MDA-MB-468 human breast cancer cell line is a widely used in vitro model derived from a triple-negative breast cancer. It is a stable, immortalized cell line that can be used for various research applications, including the study of cancer biology, drug screening, and therapeutic development.

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MDA-MB-468 (1280 citations) MDA-468 (20 citations) MDA-MB-468 cell line (5 citations) MDA-MB-468 breast (2 citations)

2 protocols using mda mb 468 human breast cancer cell line

1

Human Cancer Cell Culture Protocol

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The MDA-MB-468 human breast cancer cell line (RRID:CVCL_0419) was obtained from the American Type Culture Collection and cultured in Dulbecco’s Modified Eagle’s medium-high glucose (DME-HG) supplemented with 10% FBS, 1% L-glutamine, 1% penicillin, and streptomycin. The luciferase-expressing NCI-H1975 human lung cancer cell line was obtained from Creative Biogene and cultured in RPMI-1640 medium supplemented with 10% FBS, 1% L-glutamine, 1% penicillin, and streptomycin. Cells were authenticated using short tandem repeat profiling and tested for mycoplasma.
Pillarsetty N., Jhaveri K., Taldone T., Caldas-Lopes E., Punzalan B., Joshi S., Bolaender A., Uddin M.M., Rodina A., Yan P., Ku A., Ku T., Shah S.K., Lyashchenko S., Burnazi E., Wang T., Lecomte N., Janjigian Y., Younes A., Batlevi C.W., Guzman M.L., Roboz G.J., Koziorowski J., Zanzonico P., Alpaugh M.L., Corben A., Modi S., Norton L., Larson S.M., Lewis J.S., Chiosis G., Gerecitano J.F, & Dunphy M.P. (2019). Paradigms for precision medicine in epichaperome cancer therapy. Cancer cell, 36(5), 559-573.e7.
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2

Culturing MDA-MB-468 Breast Cancer Cells

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The MDA-MB-468 human breast cancer cell line [40 (link)] (RRID:CVCL_0419) was obtained from the American Type Culture Collection and cultured in Dulbecco’s Modified Eagle’s medium—high glucose (DME-HG) supplemented with 10% FBS, 1% L-glutamine, 1% penicillin, and streptomycin. Cells were authenticated using short tandem repeat profiling and tested for mycoplasma.
Sharma S., Joshi S., Kalidindi T., Digwal C.S., Panchal P., Lee S.G., Zanzonico P., Pillarsetty N, & Chiosis G. (2023). Unraveling the Mechanism of Epichaperome Modulation by Zelavespib: Biochemical Insights on Target Occupancy and Extended Residence Time at the Site of Action. Biomedicines, 11(10), 2599.
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