Labrafac wl

Manufactured by Gattefosse

Sourced in India, Germany

Labrafac WL is a medium-chain triglyceride (MCT) designed for use in pharmaceutical and cosmetic applications. It is a clear, colorless, and odorless liquid that is insoluble in water but miscible with organic solvents. Labrafac WL is primarily composed of caprylic and capric fatty acids.

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Lab products found in correlation

Milli q filtration system, by Merck Group (3 mentions) Fetal bovine serum (fbs), by Lonza (3 mentions) Hydrochloric acid (hcl), by Thermo Fisher Scientific (2 mentions) Poloxamer 188, by Merck Group (2 mentions) Caprol pge 860, by Gattefosse (2 mentions) Capmul mcm, by Gattefosse (2 mentions) Labrasol, by Gattefosse (2 mentions) Transcutol hp, by Gattefosse (2 mentions) Labrafil m 1944 cs, by Gattefosse (2 mentions) Cremophor elp kolliphor elp, by BASF (2 mentions) Propylene glycol, by Thermo Fisher Scientific (2 mentions) Cremophor rh40, by BASF (1 mentions) Solutol hs 15, by BASF (1 mentions) Avicel ph 101, by Merck Group (1 mentions) Poloxamer 127, by Merck Group (1 mentions) Eucalyptus oil, by SD Fine Chemicals (1 mentions) Almond oil, by SD Fine Chemicals (1 mentions) Sunflower oil, by SD Fine Chemicals (1 mentions) Kolliphor hs 15, by BASF (1 mentions) Dimethyl sulfoxide (dmso), by Merck Group (1 mentions)

Spelling variants of this product

Labrafac lipophile WL 1349 (26 citations) Labrafac (15 citations)

6 protocols using labrafac wl

Formulation and Evaluation of Cephalexin

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Cephalexin was procured from Spectrum Pharma Ltd. (Roorkee, UK). Labrafac WL, Labrasol, Caprol PGE-860, Capmul MCM, Labrafil M1944 CS and Transcutol HP were purchased from Gattefosse (Mumbai, India). The different oils (eucalyptus oil, almond oil, sunflower oil, ethyl oleate) were purchased from SD-Fine Chemicals (Mumbai, India). BASF India Ltd. (Bandra East, Mumbai, India) provided Lauroglycol 90, Cremophor RH 40, Solutol HS15, and Span 20. Other chemicals like polyethylene glycol-400 (PEG-400), PEG200 and HCl were acquired from Acros Organics (Mumbai, India). Poloxamer188 and other chemicals were obtained from Sigma Aldrich (St-Louis, MO, USA).

Zafar A., Yasir M., Alruwaili N.K., Imam S.S., Alsaidan O.A., Alshehri S., Ghoneim M.M., Alquraini A., Rawaf A., Ansari M.J, & Sara U.V. (2022). Formulation of Self-Nanoemulsifying Drug Delivery System of Cephalexin: Physiochemical Characterization and Antibacterial Evaluation. Polymers, 14(5), 1055.

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Synthesis of Nanomedicine Formulations

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All chemicals and solvents for synthesis were from Sigma Aldrich. Cremophor ELP® (Kolliphor ELP®) was provided by BASF (Ludwigshafen, Germany), Labrafac WL® (medium chain triglycerides) by Gattefossé (Saint-Priest, France). Ultrapure water was obtained using a MilliQ® filtration system (Millipore, Saint-Quentin-en-Yvelines, France). Fetal bovine serum (FBS) was acquired from Lonza (Verviers, Belgium) and Gibco-Invitrogen (Grand Island, USA).

Bouchaala R., Mercier L., Andreiuk B., Mély Y., Vandamme T., Anton N., Goetz J.G, & Klymchenko A.S. (2016). Integrity of lipid nanocarriers in bloodstream and tumor quantified by near-infrared ratiometric FRET imaging in living mice. Journal of Controlled Release, 236, 57-67.

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Piperine-Loaded Nanocarrier Formulation

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Beijing Mesochem Technology Co. Pvt. Ltd. (Beijing, China) provided the Piperine (98.21% purity). Eucalyptus oil, Almond oil, Sunflower oil, and Ethyl oleate were procured from SD-fine chemicals (Mumbai, India). Labrafac WL, Caprol PGE-860, Capmul MCM, Labrafil M1944 CS, and Transcutol HP were procured from the Gattefosse Mumbai, India. Glyceryl monolinoleate (GML) Cremophor RH 40, Solutol HS 15, and Span 20 were obtained from the BASF India Ltd. (Bandra East, Mumbai, India). Polyethylene glycol-400 (PEG-400), PEG200, propylene glycol (PG), and hydrochloric acid were purchased from Acros organic (Mumbai, India). Poloxamer188, poloxamer 127, and avicel PH101 were obtained from Sigma Aldrich (St Louis, MO, USA).

Zafar A., Imam S.S., Alruwaili N.K., Alsaidan O.A., Elkomy M.H., Ghoneim M.M., Alshehri S., Ali A.M., Alharbi K.S., Yasir M., Noorulla K.M., Alzarea S.I, & Alanazi A.S. (2021). Development of Piperine-Loaded Solid Self-Nanoemulsifying Drug Delivery System: Optimization, In-Vitro, Ex-Vivo, and In-Vivo Evaluation. Nanomaterials, 11(11), 2920.

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Synthesis and Characterization of Fluorescent Probes

Cited 1 time

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All chemicals and solvents for synthesis
were from Sigma-Aldrich. Labrafac WL (medium chain triglycerides)
by Gattefossé (Saint-Priest, France). Kolliphor HS15 (non-ionic
surfactant) was obtained from BASF (Ludwigshafen, Germany). Ultrapure
water was obtained using a Milli-Q filtration system (Millipore, Saint-Quentin-en-Yvelines,
France). FBS was acquired from Lonza (Verviers, Belgium) and Gibco-Invitrogen
(Grand Island, USA). Dihexylamino-2-(2-ethyl-hexyloxy)-benzo[a]phenoxazin-5-one (NR668) and 4′-dioctylamino-3-octyloxyflavone
(F888) were synthesized as described before.^{11 (link)}

Bouchaala R., Richert L., Anton N., Vandamme T.F., Djabi S., Mély Y, & Klymchenko A.S. (2018). Quantifying Release from Lipid Nanocarriers by Fluorescence Correlation Spectroscopy. ACS Omega, 3(10), 14333-14340.

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Synthesis of Nanomedicine Formulations

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Synthesis and Characterization of CRV431 Compound

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CRV431 was synthesized in-house to a purity of 97.3 % by modification of CsA and stored at 5°C. CsA was obtained from IVAX (Opava, Czech Republic). Lauroglycol 90, Labrasol, Labrafil M 2125, Labrafil 1944, Pecol, Labrafac WL, Capryol 90, Maisine CC, and Transcutol were purchased from Gattefosse (Montreal, Canada). Propylene glycol, filtered water, acetonitrile, methanol, scintillation vials and 12x75 ml borosilicate test tubes were purchased from Fischer Scientific (Pittsburgh, USA). Anhydrous ethanol was purchased from Commercial Alcohols (Toronto, Canada). Vitamin E, Tween 80, Tween 40, Tween 20, castor oil, dimethyl sulfoxide, Chremophor EL and Chremophor RH 40 were purchased from Sigma-Aldrich (St. Louis, USA). Span 80 was purchased from EMD Millipore Corporation (Burlington, USA). PEG 400 was purchased from BDH Incorporated (Mississauga, Canada).

Trepanier D.J., Ure D.R, & Foster R.T. (2018). Development, Characterization, and Pharmacokinetic Evaluation of a CRV431 Loaded Self-Microemulsifying Drug Delivery System. Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques, 21(1s).

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