Participants were placed in a supine position in a Siemens Biograph 64 TruePoint PET/CT camera with the liver within the 21.6‐cm axial field of view. A low‐dose CT scan (50 effective mAs with CARE Dose4D, 120 kV, pitch of 0.8 mm, and slice thickness 5.0 mm) was performed before each PET scan for definition of anatomical structures and attenuation correction of PET recordings. The 64Cu solution was administered as an i.v. bolus injection over the course of 10 s (median dose, 72.9 MBq; range, 53–77), followed by a 90‐min dynamic PET scan of the liver, recorded in list mode; time‐frame structure was 12 × 5, 8 × 15, 7 × 60, and 16 × 300 s. Then, three consecutive whole‐body PET/CT scans (top of skull to mid‐thigh; six bed positions) were performed at 1.5, 6, and 20 h after tracer administration (duration, 6, 6, and 10 min per bed position). PET images were reconstructed using three‐dimensional ordered‐subset expectation maximization with four iterations and 21 subsets, a 4‐mm Gauss filter, and 168 × 168 matrix with voxel size 4 × 4 × 5 mm3.
Biograph 64 truepoint pet ct camera
Manufactured by Siemens
Sourced in Germany
The Biograph 64 Truepoint PET/CT camera is a medical imaging device that combines Positron Emission Tomography (PET) and Computed Tomography (CT) technologies. It is designed to acquire high-quality images for diagnostic and clinical applications.
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4 protocols using biograph 64 truepoint pet ct camera
1
Copper-64 PET/CT Imaging of the Liver
2
PET Imaging of [11C]CSar and [18F]FDGal
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The pig was placed in supine position in a Siemens Biograph 64 Truepoint PET/CT camera. A low-dose CT scan (50 effective mAs, 120 kV, pitch 0.8, slice thickness 5 mm) was performed before each PET scan for attenuation correction of emission data and anatomical co-registration of PET data. Concentrations of [11C]CSar and [18F]FDGal were measured in blood samples (see below) using a well counter (Packard), and time courses for the concentration in blood were generated (kBq/mL blood vs. min). PET measurements and blood concentrations were cross-calibrated with the PET-camera and corrected for radioactive decay back to start of the PET scan.
3
11C-CSar PET Imaging of the Liver
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Patients fasted for at least 8 h prior to imaging. The participant was placed supine on the scanner bed with the liver within the 21-cm axial field of view of a Siemens Biograph 64 Truepoint PET/CT camera (Siemens Healthcare, Erlangen, Germany). A lowdose CT scan (50 effective mAs with CAREDose4D, 120 kV, pitch 0.8, slice thickness 5 mm) was used for attenuation correction of PET data and anatomical co-registration of PET and CT images. At the start of a 30-min dynamic PET scan, 11 C-CSar tracer was administered as an i.v. bolus of median 100 MBq (range 43-179) over 30 sec and then an i.v. infusion of median 54 MBq (range 40-80) over 30 min. 11 C-CSar was produced on-site at the Department of Nuclear Medicine & PET Centre at Aarhus University Hospital. 22 The PET data were corrected for radioactive decay back to start of 11 C-CSar tracer administration and reconstructed with TrueX using 4 iterations, 21 subsets, a 336×336 ×109 matrix, and a 2-mm Gauss filter. The PET image voxel size was 2×2×2 mm 3 with a spatial resolution of 4 mm full width at half maximum.
4
Pharmacokinetics of 64Cu in Humans
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The participants were placed in supine position in a Siemens Biograph™ 64 TruePoint™ PET/CT camera within the 21.6 cm axial field-of-view. A low dose CT scan (50 effective mAs with CARE Dose4D, 120 kV, pitch of 0.8 mm, slice thickness 5.0 mm) was performed before each PET scan for definition of anatomic structures and attenuation correction of the PET images. The 64Cu solution was administered as an intravenous bolus injection (n = 4; median dose 73.5 MBq, range 66–116 MBq) or dissolved in water and swallowed (n = 2; median dose 65.5 MBq, range 57–74 MBq). All participants underwent a dynamic PET scan of 90 min (dynamic PET and blood sampling were not acquired for one participant, see Table 1 ) with field-of-view over the liver, recorded in list-mode; time frame structure was 12 × 5 s, 8 × 15 s, 7 × 60 s, and 16 × 300 s. This was followed by three consecutive whole-body PET/CT scans (top of skull to mid-thigh; 6 bed positions) performed at 1.5, 6, and 20 h after tracer administration (duration 6, 6, and 10 min per bed position). The PET images were reconstructed using 3-dimensional ordered-subset expectation maximization with 4 iterations and 21 subsets, 4-mm Gauss filter, and 168 × 168 matrix with voxel size 4 x 4 x 5 mm3.
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