Imatinib (Phoenix Pharmaceuticals, Belmont, CA, USA), 2‐deoxy‐d ‐glucose (Wako, Osaka, Japan), CQ (Sigma, St Louis, MO, USA), metformin hydrochloride (LKT Laboratories, St Paul, MN, USA), rapamycin (Adooq Bioscience, Irvine, CA, USA), dasatinib (Cayman Chemical, Ann Arbor, MI, USA), bosutinib (KareBay Biochem, Ningbo, China), nilotinib (Cayman Chemical), ponatinib (Adooq Bioscience), methotrexate (Wako), cytarabine (LKT Laboratories), cisplatin (Sigma), vincristine sulfate (LKT Laboratories), STAT5 inhibitor (Calbiochem, San Diego, CA, USA), LY294002 (LC Laboratories, Woburn, MA, USA), and LY3900120 (Medchem Express, Princeton, NJ, USA).
Ponatinib
Manufactured by Adooq
Sourced in China, United States
Ponatinib is a lab equipment product designed for use in scientific research and experimentation. It is a tyrosine kinase inhibitor that functions by targeting certain enzymes involved in cellular processes. The core function of Ponatinib is to serve as a research tool for studying cell signaling pathways and their role in various biological systems.
Automatically generated - may contain errors
Lab products found in correlation
Dasatinib, by Cayman Chemical (1 mentions)
Nilotinib, by Cayman Chemical (1 mentions)
Rapamycin, by Adooq (1 mentions)
Methotrexate, by Fujifilm (1 mentions)
Cytarabine, by LKT Laboratories (1 mentions)
Metformin hydrochloride, by LKT Laboratories (1 mentions)
Imatinib, by Phoenix Pharmaceuticals (1 mentions)
2 deoxy d glucose, by Fujifilm (1 mentions)
Cisplatin, by Merck Group (1 mentions)
Ly294002, by LC Laboratories (1 mentions)
Midostaurin, by Merck Group (1 mentions)
Crenolanib, by Adooq (1 mentions)
Trametinib, by Adooq (1 mentions)
Ruxolitinib, by Adooq (1 mentions)
Afatinib, by Adooq (1 mentions)
Dasatinib, by Adooq (1 mentions)
Lenvatinib, by Adooq (1 mentions)
Regorafenib, by LGC (1 mentions)
Gefitinib, by Cayman Chemical (1 mentions)
Elacridar, by LGC (1 mentions)
3 protocols using ponatinib
1
Pharmacological Interventions for Cancer
2
Characterization of FLT3-mutant AML Cell Lines
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Midostaurin was purchased from Sigma (St. Louis, MO, USA), crenolanib, quizartinib and ponatinib were purchased from Adooq Bioscience (Irvine, CA, USA). MV4–11 cell line was a kind gift from Dr. Mark Levis (Johns Hopkins University). MOLM-14 (FLT3-ITD, D835Y) and MOLM-14 (FLT3-ITD, F691 L) [25 (link)] were kind gifts from Dr. Neil Shah (UCSF). The cells were routinely maintained in Roswell Park Memorial Institute (RPMI) 1640 medium supplemented with 10% fetal bovine serum at 37 °C with 5% CO2.
3
Cell-based Assay of Multi-Targeted Kinase Inhibitors
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Regorafenib, M-2, M-5, and elacridar were purchased from Toronto Research Chemicals (North York, ON). Ko143 was from Sigma-Aldrich (St. Louis, MO). Imatinib mesylate was from Focus Biomolecules (Plymouth Meeting, PA). Afatinib, bortezomib, cabozantinib, carfilzomib, dabrafenib, dacomitinib, dasatinib, lapatinib, lenvatinib, pazopanib, ponatinib, ruxolitinib, tofacitinib, trametinib, vandetanib, and vemurafenib were from AdooQ Bioscience (Irvine, CA). Sorafenib was from LKT Laboratories Inc. (St. Paul, MN). Sunitinib was from Synkinase Pty Ltd. (San Diego, CA). Crizotinib was from LC Laboratories Inc. (Woburn, MA). Gefitinib and erlotinib were from Cayman Chemical Company (Ann Arbor, MI). Nilotinib was from ChemScene, LLC (Monmouth Junction, NJ). All other chemicals and reagents were of analytical grade and were obtained from commercial sources.
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