Boc amino acids

Manufactured by Peptide Institute

Sourced in Japan

Boc–amino acids are a class of amino acid derivatives used in organic synthesis, particularly in peptide synthesis. They serve as precursors for the synthesis of peptides and proteins by providing protected amino acid building blocks. The Boc (tert-butyloxycarbonyl) protecting group allows for the selective coupling and deprotection of amino acids during the stepwise assembly of peptide chains.

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Lab products found in correlation

Bromoacetic acid, by Merck Group (1 mentions) Diethyl ether, by Thermo Fisher Scientific (1 mentions) P cresol, by Merck Group (1 mentions) O 7 azabenzotriazol 1 yl n n n n tetramethyluronium hexafluorophosphate hatu, by GL Biochem (1 mentions) N n dimethylformamide dmf dichloromethane, by Thermo Fisher Scientific (1 mentions) N n diisopropylethylamine, by Thermo Fisher Scientific (1 mentions) 2 1h benzotriazol 1 yl 1 1 3 3 tetramethyluronium hexafluorophosphate hbtu, by Peptide Institute (1 mentions) Hplc grade acetonitrile, by Thermo Fisher Scientific (1 mentions) Dimethyl sulfoxide (dmso), by Merck Group (1 mentions) Glutathione (gsh), by Peptide Institute (1 mentions)

2 protocols using boc amino acids

Solid-Phase Peptide Synthesis

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2-(1H-Benzotriazol-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate (HBTU), p-methylbenzhydrylamine resin, and Boc–amino acids were obtained from Peptides International, Kentucky. O-(7-Azabenzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium hexafluorophosphate (HATU) was obtained from GL Biochem, Shanghai. Boc-Val-OCH₂-Pam-resin was purchased from Rapp Polymere, Germany. Boc-Ala-OCH₂-Pam-resin and N,N-diisopropylethylamine were obtained from Applied Biosystems, Foster City. N,N-Dimethylformamide (DMF), dichloromethane, diethyl ether, and HPLC-grade acetonitrile were purchased from Fisher (Irvington, New York, USA). Trifluoroacetic acid (TFA) was obtained from Halocarbon Products, New Jersey. HF was purchased from Matheson. DMSO, N,N-diisopropylcarbodiimide (DIC), ThT, p-cresol, bromoacetic acid, and 2-nitrobenzylamine were obtained from Sigma-Aldrich (St. Louis, MO, USA).

Johnson E.C., Lanning J.D, & Meredith S.C. (2016). Peptide backbone modification in the bend region of amyloid-β inhibits fibrillogenesis but not oligomer formation. Journal of peptide science : an official publication of the European Peptide Society, 22(5), 368-373.

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Peptide Synthesis and Labeling

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Boc-amino acids, HBTU, HOBt, and glutathione were purchased from the Peptide Institute, Inc. (Osaka, Japan). BPTI, N-ethylmaleimide, and N-succinimidyl 6-maleimidohexanoate were purchased from GE healthcare (Chicago, IL, USA), Nacalai Tesque (Kyoto, Japan), and Tokyo Chemical Industry Co., Ltd. (Tokyo, Japan), respectively. All chemicals and solvents used were of reagent grade.

Sakata N., Murakami Y., Miyazawa M., Shimamoto S, & Hidaka Y. (2023). A Novel Peptide Reagent for Investigating Disulfide-Coupled Folding Intermediates of Mid-Size Proteins. Molecules, 28(8), 3494.

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