Aquilion 64

Manufactured by Canon

Sourced in Japan, United States, Germany

The Aquilion 64 is a computed tomography (CT) scanner manufactured by Canon. It is a multi-slice CT system capable of acquiring 64 slices per rotation. The Aquilion 64 is designed to provide high-quality medical imaging for various diagnostic and clinical applications.

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Lab products found in correlation

Aquilion one, by Canon (10 mentions) Aquilion prime, by Canon (5 mentions) Lightspeed vct, by GE Healthcare (4 mentions) Aquilion precision, by Canon (3 mentions) Somatom force, by Siemens (3 mentions) Ultravist 370, by Bayer (3 mentions) Iopamiron 370, by Bayer (2 mentions) Aquilion one vision edition, by Canon (2 mentions) Aquilion one genesis edition, by Canon (2 mentions) Aquilion prime sp iedition, by Canon (2 mentions) Aquilion 16, by Canon (2 mentions) Revolution ct, by GE Healthcare (2 mentions) Somatom definition flash, by Siemens (2 mentions) Brilliance 40, by Philips (2 mentions) Alexion, by Canon (1 mentions) Activion 16, by Canon (1 mentions) Revolution hd, by GE Healthcare (1 mentions) Revolution evo, by GE Healthcare (1 mentions) Aquilion one 320 slice, by Canon (1 mentions) Accupaque 350, by GE Healthcare (1 mentions)

48 protocols using aquilion 64

Dual-Phase CT Angiography Protocol

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Two types of CT equipment were used. One was an area-detector CT (Aquilion ONE ViSION Edition, Canon Medical Systems), and scanning parameters were as follows: 0.5 mm × 80 row, 120 kVp, three-dimensional auto-exposure control (Volume EC: SD12@5 mm), 0.5 s/rotation, 0.813 beam pitch, 512 × 512 matrix, 300–350-mm field-of-view, and 1- or 2-mm reconstruction. Noise reduction was achieved by a hybrid iterative reconstruction (Adaptive Iterative Dose Reduction or AIDR 3D Weak). Second CT was Aquilion 64 (Canon Medical Systems), and parameters were as follows; 0.5 mm × 64 row, 120 kVp, three-dimensional auto-exposure control (Volume EC: SD12@5 mm), 0.5 s/rotation, 0.828 beam pitch, 512 × 512 matrix, 300–350-mm field-of-view, and 2-mm reconstruction (filtered back projection).
After obtaining precontrast images, 600 mgI/kg iodine contrast medium (Iopamiron 370, Bayer Health Care) was injected for 30 s at a variable injection rate, and arterial dominant phase images were obtained using bolus tracking method, followed by portal dominant phase at 60 s, and equilibrium phase images at 240 s after the commencement of contrast medium injection.

Sakamoto K., Tanaka S., Sato K., Ito E., Nishiyama M., Urakawa H., Arima H, & Yoshimitsu K. (2022). What is the “washout” of hepatocellular carcinoma as observed on the equilibrium phase CT?: consideration based on the concept of extracellular volume fraction. Japanese Journal of Radiology, 40(11), 1148-1155.

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Chest CT Imaging Protocol for Lung

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All patients were scanned using 64-row detector CT scanners (Aquilion 64; Canon Medical Systems, Otawara, Tochigi, Japan). Chest CT was performed in the supine position during breath hold at full inspiration and expiration. The scanning parameters were as follows: collimation, 0.5 mm; tube voltage, 120 kVp; tube current 200 mA (at inspiration) and 80 mA (at expiration); gantry rotation time, 0.5 seconds; beam pitch, 0.828 (53/64). All images were reconstructed using a standard kernel (for mediastinum) with a slice thickness of 0.5 mm. The imaging field of view was 320 mm, and the pixel size was 0.625×0.625 mm.

Onoe R., Yamashiro T., Handa H., Azagami S., Matsuoka S., Inoue T., Miyazawa T, & Mineshita M. (2018). 3D-measurement of tracheobronchial angles on inspiratory and expiratory chest CT in COPD: respiratory changes and correlation with airflow limitation. International Journal of Chronic Obstructive Pulmonary Disease, 13, 2399-2407.

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Immediate CT Imaging of Patients

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All patients underwent CT immediately after arriving at the hospital. CT images (64 × 0.5 mm or 32 × 1.0 mm-detector row/automatic exposure control/120 kVp) were obtained with the Aquilion 64 or the Aquilion 64CX system (Canon Medical, Tochigi, Japan). The 0.5 mm or 1.0 mm-slice thickness high-resolution computed tomography images were reconstructed using the FC51 reconstruct function.

Hirotsu Y., Kakizaki Y., Saito A., Tsutsui T., Hanawa S., Yamaki H., Ide S., Kawaguchi M., Kobayashi H., Miyashita Y, & Omata M. (2023). Lung tropism in hospitalized patients following infection with SARS-CoV-2 variants from D614G to Omicron BA.2. Communications Medicine, 3, 32.

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Volumetric Assessment of Lung Cancer

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All patients underwent chest CT within two months prior to surgery. Chest CT was performed in the supine position during an inspiratory breath-hold using various multidetector row scanners: an Aquilion prime (CANON MEDICAL SYSTEMS CORPORATION, Tochigi, Japan), Aquilion ONE (CANON), Alexion (CANON), Activion16 (CANON), and Aquilion64 (CANON). All CT data were resampled at 0.5 × 0.5 × 1.0 mm resolution with trilinear interpolation.
Targeted lung cancer was segmented with a semiautomated method using the 3D Slicer software program, ver. 4.10.2 (https://www.slicer.org/). Lung cancer was denoted with solid and ground-glass components. We defined solid components as those of > − 80 Hounsfield Unit (HU) and ground-glass opacity as components of > − 600 HU and < − 80 HU. The volume of interest (VOI) of lung cancer was delineated by the fusion of the solid and ground-glass parts.

Onozato Y., Nakajima T., Yokota H., Morimoto J., Nishiyama A., Toyoda T., Inage T., Tanaka K., Sakairi Y., Suzuki H., Uno T, & Yoshino I. (2021). Radiomics is feasible for prediction of spread through air spaces in patients with nonsmall cell lung cancer. Scientific Reports, 11, 13526.

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Standardized CT Imaging Protocol for Lymphoma and Liver Cirrhosis Patients

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For the lymphoma patients, the baseline staging protocol was standardized and included a contrast-enhanced CT of the neck, chest, abdomen and pelvis. In patients with liver cirrhosis, the study protocol included either the chest, abdomen, and pelvis, or only abdomen and pelvis, depending on the clinical question.
CT scanners from two manufacturers were used to acquire the CT scans: Aquilion One (number of performed examinations = 22), Aquilion PRIME (n = 38), and Aquilion 64 (n = 2) from Canon Medical Systems (Otawara, Tochigi, Japan) and Revolution HD (n = 37), Revolution EVO (n = 42) and LightSpeed VCT (n = 8) from General Electric Healthcare (Boston, MA, USA).
The contrast agents used were iomeprol (Imeron 400^®, Bracco Imaging, Milan, Italy) iobitridol (Xenetix 350^®, Guerbert, Villepinte, France), and iopromide (Ultravist 370^®, Bayer, Leverkusen, Germany) with amounts varying between 100 and 140 mL. Portal venous phase imaging was performed at 70–80 s after the intravenous administration of the contrast agent. Axial reconstructions with a slice thickness of 5 mm without gaps were used in this study. Figure 2 shows a sample of CT images in coronal reconstruction.

Meddeb A., Kossen T., Bressem K.K., Molinski N., Hamm B, & Nagel S.N. (2022). Two-Stage Deep Learning Model for Automated Segmentation and Classification of Splenomegaly. Cancers, 14(22), 5476.

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Contrast-Enhanced CT Imaging Protocol

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In all 85 patients, CT studies were performed using a multi-detector CT system (Aquilion 64; Canon Medical Systems, Otawara, Japan) within 24 hours of hospital arrival. CT studies were performed involving both nonenhanced and contrast-enhanced CT in all patients. Contrast-enhanced CT was conducted using a bolus intravenous injection of 60 to 90 mL of nonionic iodinated contrast material using a power injector, and CT data acquisition began at 20 to 30 seconds and 70 to 90 seconds (2 phases) after the start of contrast material injection. The image reconstruction section thickness and the section interval were 5.0 and 5.0 mm for routine axial image reconstruction, and 1.0 and 1.0 mm for multiplanar reformations and 3D image reconstruction, respectively

Hirata K., Oda S., Suzuki R, & Sugahara T. (2020). Long-term prognostic value of the combined assessment of clinical and computed tomography findings in type: An acute aortic dissection. Medicine, 99(45), e23008.

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Abdominal CT Imaging with Contrast

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The CT scanners used for imaging were a Canon Aquilion 64 (64 slice), an Aquilion Prime (80 slice), an Aquilion One (320 slice) (Canon Medical Systems, Ōtawara, Japan), and a GE Lightspeed VCT (GEL) scanner. Iodine-containing contrast agents such as Accupaque 350 (GE Healthcare, Chicago, Ill, USA) and Ultravist 370 (Bayer Vital GmbH, Leverkusen, Germany) were used in weight-adapted doses. The standard examination algorithm consisted of an initial arterial examination of the upper abdomen 40 s after the start of the machine contrast injection and a subsequent venous phase of the abdomen and pelvis 120 s after contrast injection.

Dahlmann S., Bressem K., Bashian B., Ulas S.T., Rattunde M., Busch F., Makowski M.R., Ziegeler K, & Adams L. (2022). Sex Differences in Renal Cell Carcinoma: The Importance of Body Composition. Annals of Surgical Oncology, 30(2), 1269-1276.

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Adrenal Tumor Screening Using Contrast-Enhanced CT

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Contrast-enhanced CT images were obtained before AVS using a 64-row detector scanner (Aquilion 64; Canon Medical Systems, Otawara, Japan) or a 320-row detector scanner (Aquilion One or Aquilion One GENESIS Edition; Canon Medical Systems). The screening of adrenal tumors was conducted at the following settings: a 1:1 table pitch; collimation, 0.5-1 mm; reconstruction thickness/interval, 1.0 mm/1.0 mm; 100-120 kVp with automatic exposure control; and adaptive iterative dose reduction (AIDR) [20] . After injecting the contrast medium for 30 s, three-phase images were obtained after 45 s, 55 s, and 180 s. The first and second phases' scan ranges were the upper abdomen, while the third phase covered the abdomen and pelvis. The total iodine dose was 600 mg/kg (maximum amount, 45 g). The median interval between CT and AVS was 62 days (range, 1-1281 days).

Morita S., Yamamoto T., Kamoshida K., Yamazaki H., Yatabe M., Ichihara A, & Sakai S. (2021). High Deep Femoral Artery Bifurcation Can Disturb Safe Femoral Venous Access: CT Assessment in Patients Who Underwent Femoral Venous Access Under Doppler Ultrasound Guidance. Interventional Radiology, 6(2), 29-36.

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Diagnostic Pathway for DVT/PE

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DVT/PE was confirmed with enhanced CT scan when the plasma D-dimer value exceeded approximately 10 μg/ml. Enhanced CT scanning was performed with a 64-row multidetector scanner (Aquilion64; Canon Medical Systems Corporation, Ohtawara, Japan). A total non-ionic contrast material volume of 80 to 100 ml (iodine concentration, 300–370 mg/ml) was injected at the rate of 2.4 to 3.0 ml/s according to the patient’s weight. For pulmonary embolism, the scanning was started at 25 s after the start of injection, and the whole lung area was assessed. For deep venous thrombosis, the scanning was started at 210 s after the start of injection and the region from the diaphragm to the toes was investigated. In both areas, data were acquired with 0.5 mm thickness scans, and reconstructed for 2.0 mm-slice axial images, 5 mm-slice sagittal images, and 5 mm-slice coronal images. CT images were reviewed by a radiologist and the patient was accordingly diagnosed with DVT/PE. If a patient had any symptom of DVT/PE, we performed enhanced CT immediately, regardless of the D-dimer value. When the plasma D-dimer value did not exceed approximately 10 μg/ml and there were no symptoms, we performed physical examination and ultrasonography, if necessary, for observation.

Otsuka H., Izumi M., Ota E, & Mochizuki N. (2020). Incidence of postsurgical pulmonary embolism and deep venous thrombosis: a single-center retrospective observational study. JA Clinical Reports, 6, 22.

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Dual-CT Multimodal Imaging Protocol

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Two CT instruments were used in this study. One was an area-detector CT (Aquilion ONE ViSION Edition, Canon Medical Systems, Tokyo, Japan), and scanning parameters were as follows: 0.5 mm × 80 row, 120 kVp, three-dimensional auto-exposure control (Volume EC: SD12@5 mm), 0.5 sec/rotation, 0.813 beam pitch, 512 × 512 matrix, 300-350 mm field-of-view, and 2 mm reconstruction. Noise reduction was achieved using a hybrid iterative reconstruction (ADIR 3D Weak). The other CT used was 64-row multi-detector CT (Aquilion 64, Canon Medical Systems, Tokyo, Japan), with parameters shown below: 0.5 mm × 64 row, 120 kVp, three-dimensional auto-exposure control (Volume EC: SD12@5 mm), 0.5 sec/rotation, 0.828 beam pitch, 512 × 512 matrix, 300-350 mm field-of-view, and 2mm reconstruction (filtered back projection). Portal venous phase was additionally reconstructed along the coronal plane with 2 mm contiguous slice thickness in either CT.
After obtaining unenhanced images, 600 mg/kg iodine contrast medium (Iopamiron 370, Bayer Health Care, Osaka, Japan) was injected for 30 sec at a variable injection rate, and arterial dominant phase images were obtained using a bolus tracking method, followed by portal dominant phase at 60 sec, and equilibrium phase images at 240 sec after the commencement of contrast medium injection.

Sato K., Tanaka S., Urakawa H., Murayama R., Hisatomi E., Takayama Y, & Yoshimitsu K. (2024). Gallbladder fossa nodularity in the liver as observed in alcoholic liver disease patients: Analysis based on hepatobiliary phase signal intensity on gadoxetate-enhanced MRI and extracellular volume fraction calculated from routine CT data. Global health & medicine, 6(3).

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