Tbh 325

Weight variation, hardness (TBH 325, Erweka, Germany), friability (TAR, Erweka, Germany), content uniformity (Kulkarni et al., 2012 ) and disintegration time (DST-3/6 automated disintegration tester, Logan, UT) quality control tests were applied onto 10 liquisolid tablets sample from each formula according to standardized pharmacopeial United State Pharmacopeia (USP) conditions (U.S. Pharmacopeia and National Formulary, 2002 ).

The thickness, hardness, diameter, and weight of effervescent matrix tablets were evaluated for their physical characteristics. Ten tablets of each formulation were tested for their diameter and hardness with a hardness tester (ERWEKA, model: TBH-325, Langen, Germany), and the thickness was measured with a thickness tester (Teclock, model: SM-112, Nagano, Japan). Tablet weights (n = 10) were determined using an analytical balance (model: CP224S, Sartorius, Göttingen, Germany), and the average weight and standard deviation (SD) were calculated. The statistical significance of the obtained data was examined using the independent t-test with a significant level at p < 0.05. The analysis was performed using SPSS for Windows (Version 11.5, SPSS Inc., Chicago, IL, USA).

To measure tablet hardness, 10 tablets of each layer were prepared. Again, 1305 mg of the granules of metformin HCl and the 250 mg of the granules of dapagliflozin l-proline were weighed and inserted into a die and compressed at 30 kN using a single-punch tablet machine (HANDTAB-200, Ichihashi-Seiki Co., Ltd., Kyoto, Japan) with an oval-shaped tablet punch (21 mm × 11 mm). The hardness of each layer tablet was measured using a hardness tester (TBH 325, ERWEKA GmbH, Langen, Hesse, Germany). Hardness was used for the mean values of the 10 tablets.