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2 protocols using loratadine

1

Screening Antimicrobial Compounds Library

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Oxacillin sodium (HY-B0465), cefazolin sodium (HY-B1078), vancomycin (HY-B0671), linezolid (HY-10394), daptomycin (HY-B0108), rifampin (HY-B0272), minocycline hydrochloride (HY-17412), azithromycin (HY-17506), clindamycin (HY-B0408), loratadine (HY-17043), desloratadine (HY-B0539), and Chemicals Screening Libraries (HY-LD-000001025; 1,333 chemicals, part of the FDA-Approved Drug Library) were purchased from MedChemExpress (MCE, Shanghai, China). loratadine analogues Lo-b1 to b3, Lo-c1 to c5, Lo-FITC, and Lo-biotin were designed and synthesized at Xi'an Ruixi Biological Technology Co., Ltd (Xi'an, China). Media were supplemented with 50 mg/L Ca2+ for in vitro daptomycin testing.
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2

Cannabinoid Profiling and Pharmacological Interactions

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CBD, CBDA, CBDV, CBG, CBGA, Δ9-THC and Δ9-THCA were purchased from THC Pharm GmbH (Frankfurt, GER). CBGA was also purchased from Cayman Chemical (Ann Arbor, USA). CBDA was also generously provided by Medropharm GmbH (Schönenberg, CHE). CBDVA was synthesized by Professor Michael Kassiou at the University of Sydney. Elacridar, digoxin and loratadine were purchased from MedChem Express LLC (Princeton, USA). Prazosin and Lucifer Yellow CH dipotassium salt were purchased from Sigma-Aldrich (St. Louis, USA). The full-spectrum cannabis extract was purchased from Ecofibre (Brisbane, AUS) with its cannabinoid content presented in Supplemental Table 1. Terpene content of the full-spectrum extract in percent content (w/w) is as follows: β-caryophyllene, 0.525; β-linalool, 0.011; D-limonene, 0.006 and β-pinene, 0.004.
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