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Doxorubicin hydrochlorine

Manufactured by Merck Group
Sourced in United States

Doxorubicin hydrochloride is a cytotoxic chemotherapeutic agent used in the treatment of various types of cancer. It is a red-colored crystalline powder that is soluble in water and alcohol. Doxorubicin hydrochloride functions by intercalating with DNA and inhibiting the enzyme topoisomerase II, which leads to the disruption of DNA replication and transcription.

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2 protocols using doxorubicin hydrochlorine

1

Antioxidant Assay Protocol for Natural Products

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Daunomycin hydrochlorine (≥90%), doxorubicin hydrochlorine (≥98%), streptomycin (≥98%), phosphate-buffered saline (PBS) without Ca2+ and Mg2+, fetal bovine serum (FBS), resazurin, MEM medium without phenol red (≥98%), o-dianisidine (≥95%), veratryl alcohol (96%), 2,6-dimethoxyphenol (99%), ABTS (2,2′-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) (≥98%), DPPH (2,2-diphenyl-1-picrylhydrazyl), trolox (97%), peroxidase, type II from horseradish (200 KU) and catechol (≥99%) were purchased from Sigma-Aldrich (St. Louis, MO, USA). All other chemicals and reagents were of analytical grade.
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2

Antioxidant Assays with Phytochemicals

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Daunomycin hydrochlorine (≥90%), doxorubicin hydrochlorine (≥98%), mitoxantrone hydrochlorine (≥90%), 2.6-dimethoxyphenol (99%; 2.6-DMP), nitrotetrazolium blue (99%; NBT), protocatechuic acid (97%), sodium alginate, calcium chloride (93%), 30% hydrogen peroxide, malonic acid (99%), DPPH (2.2-diphenyl-1-picrylhydrazyl), Trolox (97%), and the glucose oxidase assay were purchased from Sigma-Aldrich (St. Louis, MO, USA). The catalase assay kit was purchased from Merck Millipore. All other chemicals and reagents were of analytical grade.
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