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Duraseal

Manufactured by Integra LifeSciences
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Duraseal is a surgical sealant product developed by Integra LifeSciences. It is designed to provide a watertight seal for various tissue types during surgical procedures.

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Lab products found in correlation

Duragen, by Integra LifeSciences (2 mentions) Evicel, by Johnson & Johnson (1 mentions) Seprafilm, by Baxter (1 mentions) Coseal, by Baxter (1 mentions) Surgicel, by Johnson & Johnson (1 mentions)

5 protocols using duraseal

1

Measuring Hydrogel Adhesive Strength

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The adhesive strengths of the hydrogels were determined by the lap shear adhesion test with a modified protocol 37 (link). The bovine pericardium was cut into 2.5 cm × 2.5 cm strips and hydrated in PBS (pH = 7.4). PEG-DA adhesives were cured between two partially overlapping bovine pericardial with an overlapping area of 2.5 cm × 1 cm. The adhesive joint was compressed with a 100 g weight for 5 min and further conditioned in PBS (pH = 7.4) at 37 °C for overnight prior to the testing. The dimensions of the contact area of each adhesive joint were measured before testing. A commercial PEG-based sealant, DuraSeal (Integra LifeSciences, Inc.), was prepared the same way and tested for comparison. The adhesive joints were pulled to failure at a rate of 0.1 mm s−1 until the tissues separate using an Electroforce® machine (Bose Electroforce Group, MN). The adhesive strength was determined by the max load divided by the initial contact area of the adhesive joint.
Zhang Z., Pinnaratip R., Ong K.G, & Lee B.P. (2019). Correlating the mass and mechanical property changes during the degradation of PEG-based adhesive. Journal of applied polymer science, 137(10), 10.1002/app.48451.
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2

Dural Puncture and MER with Duraseal Sealant

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After cauterizing the dura mater and setting the microelectrode, the 5 mm diameter hole was created in the dura mater without damaging the arachnoid or the pia mater, as in Group I. Subsequently, just after the cortical surface by 4 mm diameter was cauterized in preparation for the re-puncture, it was covered with Duraseal (1 ml, INTEGRA Life-Sciences, Plainsboro, NJ, USA) (Figs. 1A and 1B). The needle electrode for MER was then inserted. When re-puncture was needed, the first application of Duraseal was not removed.
SASAKI T., AGARI T., KUWAHARA K., KIN I., OKAZAKI M., SASADA S., SHINKO A., KAMEDA M., YASUHARA T, & DATE I. (2018). Efficacy of Dural Sealant System for Preventing Brain Shift and Improving Accuracy in Deep Brain Stimulation Surgery. Neurologia medico-chirurgica, 58(5), 199-205.
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3

Comparative Evaluation of Surgical Sealants

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The various surgical sealants used in ex vivo testing include SepraFilm (Baxter, Deerfield, IL, USA), DuraSeal (Integra LifeSciences, Plainsboro, NJ, USA), Evicel (Ethicon, Somerville, NJ, USA), Surgicel (Ethicon), and Coseal (Baxter).
Zheng Y., Pierce A.F., Wagner W.L., Khalil H.A., Chen Z., Funaya C., Ackermann M, & Mentzer S.J. (2021). Biomaterial-Assisted Anastomotic Healing: Serosal Adhesion of Pectin Films. Polymers, 13(16), 2811.
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4

Chronic Neural Recording in Marmosets

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Two marmosets (Callithrix jacchus), one male (monkey W) and one female (monkey T) participated in this study. The sample size was chosen to minimize animal use while providing for reproducibility of results. No blinding or randomization was applied. Each marmoset was fitted with a headpost for head stabilization and eye tracking. The headpost contained a hollow chamber housing an Omnetics connector for a Utah array, which was chronically implanted in a subsequent surgery. For that surgery, a 7×10mm craniotomy was made over area MT (stereotaxic coordinates 2mm anterior, 12mm dorsal). An 8×8 (64 channel, monkey W) and 9×9 with alternating channels removed (40 channel, monkey T) Utah array was chronically implanted over area MT using a pneumatic inserter wand. The electrodes spacing was 400μM with a pitch depth of 1.5mm. The craniotomy was closed with Duraseal (Integra Life Sciences, monkey W) or Duragen (Integra Life Sciences, monkey T), and covered with a titanium mesh embedded in dental acrylic. All surgical procedures were performed with the monkeys under general anesthesia in an aseptic environment in compliance with NIH guidelines. All experimental methods were approved by the Institutional Animal Care and Use Committee (IACUC) of the Salk Institute for Biological Studies and conformed to NIH guidelines.
Davis Z.W., Muller L., Trujillo J.M., Sejnowski T, & Reynolds J.H. (2020). Spontaneous Traveling Cortical Waves Gate Perception in Behaving Primates. Nature, 587(7834), 432-436.
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5

Chronic Neural Recording in Marmosets

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Two marmosets (Callithrix jacchus), one male (monkey W) and one female (monkey T) participated in this study. The sample size was chosen to minimize animal use while providing for reproducibility of results. No blinding or randomization was applied. Each marmoset was fitted with a headpost for head stabilization and eye tracking. The headpost contained a hollow chamber housing an Omnetics connector for a Utah array, which was chronically implanted in a subsequent surgery. For that surgery, a 7×10mm craniotomy was made over area MT (stereotaxic coordinates 2mm anterior, 12mm dorsal). An 8×8 (64 channel, monkey W) and 9×9 with alternating channels removed (40 channel, monkey T) Utah array was chronically implanted over area MT using a pneumatic inserter wand. The electrodes spacing was 400μM with a pitch depth of 1.5mm. The craniotomy was closed with Duraseal (Integra Life Sciences, monkey W) or Duragen (Integra Life Sciences, monkey T), and covered with a titanium mesh embedded in dental acrylic. All surgical procedures were performed with the monkeys under general anesthesia in an aseptic environment in compliance with NIH guidelines. All experimental methods were approved by the Institutional Animal Care and Use Committee (IACUC) of the Salk Institute for Biological Studies and conformed to NIH guidelines.
Davis Z.W., Muller L., Trujillo J.M., Sejnowski T, & Reynolds J.H. (2020). Spontaneous Traveling Cortical Waves Gate Perception in Behaving Primates. Nature, 587(7834), 432-436.
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