3.0 t mr system

Participants were scanned (pre and post-training) using a 3.0 T MR system (Philips Achieva, Eindhoven, the Netherlands) that was equipped with 80 mT/m gradients and a 32-channel head coil. The parameters for the functional image acquisition are described in the supplementary section. Morphometric image acquisition was previously described (Paradela et al., 2021 (link)).
During the fMRI exam, participants performed a WM factorial block-design task adapted from Brehmer et al. under two WM load conditions (low vs. high) and their respective controls (Klingberg et al., 2002a (link); Brehmer et al., 2011 (link)). A block-design task was used, with randomized order of WM-low, WM-high, and the two control conditions (Klingberg et al., 2002a (link); Brehmer et al., 2011 (link)). Stimuli were programmed and presented using E-prime (Version 1.2), which also recorded behavioral performance (accuracy and reaction time).

All patients were scanned on a 3.0T MR system (Achieva, Philips Medical Systems, Best, Netherlands) with a 16-channel Sense Torso XL coil. The MRI sequences included axial T1-weighted imaging, axial, coronal, and sagittal T2WI, axial DWI, pre-contrast axial fat- suppressed T1 high-resolution isotropic volume examination (THRIVE), and post-contrast axial breath-hold DCE that performed with fat-suppressed enhanced-THRIVE. The detailed acquisition parameters of routine MR sequences are shown in Table 1.
A total of 20 periods of dynamic enhanced prostate scanning were performed, with a total scanning time of 2 min. The contrast agent was injected at the end of the first period. Gadodiamide (MEDRAD Healthcare, 0.2 mmol/kg body weight) was administrated via intravenously pumping (3.0 ml/s) followed by 20 ml of a saline flush at the same rate.
The PI-RADS v2.1 score for each case was evaluated by two radiologists (with 9 and 11 years of experience in PCa diagnosis, respectively), blinded to pathological data except for tumor location. Any discrepancy among the two observers was resolved by consulting with a third radiologist (with 20 years of experience in PCa diagnosis). The PI-RADS v2.1 scores were assessed on T2WI, DWI, and DCE-MRI images. If there were multiple lesions, the PI-RADS score was determined by the largest or most aggressive lesion.

We used a 3.0 T MR system (Achieva, Philips Medical Systems, Best, The Netherlands) to acquire a high-resolution T1-anatomical brain image with a 3D T1-weighted turbo field echo (T1TFE) sequence (TR = 9.9 ms, TE = 4.6 ms, flip angle = 8°, field of view = 220 × 220, 180 slices, thickness = 1 mm, voxel size = 0.98 mm × 0.98 mm × 1 mm) and whole-brain resting-state functional image using a T2*-weighted echo-planar imaging sequence (TR = 2700 ms, TE = 35 ms, flip angle = 90°, field of view = 220 × 220, 35 slices, thickness = 4 mm, voxel size = 1.53 mm × 1.53 mm × 4 mm, 180 volumes). During functional MRI (fMRI) scanning, participants were instructed to rest with their eyes open, not to sleep, and not to think about anything in particular.