Human igm

Manufactured by Fortis Life Sciences

Human IgM is a laboratory product used to detect and quantify the presence of IgM antibodies in biological samples. IgM is the first class of antibodies produced by the body in response to an initial infection or antigen exposure. The core function of Human IgM is to provide information about the immune system's early response to a potential pathogen or other foreign substance.

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Lab products found in correlation

Anti cd46 clone gb 24, by Novus Biologicals (1 mentions) Biotin anti cd46 clone mem 258, by Novus Biologicals (1 mentions) Complement c3b human elisa, by Abcam (1 mentions)

Close spelling variants of this product

Anti-human IgM antibody Human IgM ELISA Quantitation Set Human IgG/IgM ELISA Quantitation Set Human IgM ELISA kit

2 protocols using human igm

Plasma IgM and IgG Quantification

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Human IgM and IgG concentrations in plasma were determined using Human IgM and IgG ELISA Kit (Bethyl Laboratories), respectively, following the manufacturer’s instructions.

Audigé A., Rochat M.A., Li D., Ivic S., Fahrny A., Muller C.K., Gers-Huber G., Myburgh R., Bredl S., Schlaepfer E., Scherrer A.U., Kuster S.P, & Speck R.F. (2017). Long-term leukocyte reconstitution in NSG mice transplanted with human cord blood hematopoietic stem and progenitor cells. BMC Immunology, 18, 28.

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Quantification of Immune Mediators

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Amounts of sCD46 in culture supernatants was measured by sandwich ELISA (detection range: 7.8–500 ng/mL): anti-CD46 (clone GB-24),³⁸ and biotin anti-CD46 (clone MEM-258, Novus Biologicals). IgM and IgG in B cell tissue culture supernatants were analyzed using the human IgM (detection range: 15.6–1000 ng/mL) and IgG (detection range 7.8–1000 ng/mL) ELISA quantification (Bethyl Laboratories). MMP-9 in T cell tissue culture supernatants was measured using the LegendMax™ ELISA (BioLegend; detection range: 62.5–4000 pg/mL). C3b was analyzed using the Complement C3b human ELISA (Abcam; detection range: 0.15–10 ng/mL).

Ellinghaus U., Cortini A., Pinder C.L., Le Friec G., Kemper C, & Vyse T.J. (2017). Dysregulated CD46 shedding interferes with Th1‐contraction in systemic lupus erythematosus. European Journal of Immunology, 47(7), 1200-1210.

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