Mammography was performed using a Lorad Selenia (Hologic, Bedford, MA, USA). US examinations were performed using one of the following high-resolution US systems with an 11–18 MHz linear transducer: HDI 5000 (Philips Healthcare, Bothell, WA, USA), Aixplorer (SuperSonic Imagine, Aix-en-Provence, France), and Aplio I800 (Canon Medical Systems Corporation, Tokyo, Japan). Two radiologists with 2–12 years of experience in breast imaging interpretation retrospectively reviewed the radiologic images by consensus and were blinded to the final pathologic diagnosis. The images were assessed according to the Breast Imaging Reporting and Data System (BI-RADS) lexicon for mammography and US [19 ]. Breast density, lesion visibility, and lesion type (mass, asymmetry, or calcification) were assessed using mammography. The shape (oval to round, irregular), margin (circumscribed, non-circumscribed), orientation (parallel, nonparallel), echo pattern (hyper-iso, hypo, complex cystic and solid), posterior feature (enhancement, shadowing, absent), calcification (absent, present), and vascularity (absent, present) of the lesion were evaluated on US. Associated ductal change, such as dilatation or continuation with adjacent ducts and the presence of an intraductal feature, were also recorded.
Lorad selenia
Manufactured by Hologic
Sourced in United States
The Lorad Selenia is a digital mammography system designed for breast imaging. It captures high-quality digital images of the breast, which can be used by healthcare professionals for diagnosis and evaluation.
Automatically generated - may contain errors
Lab products found in correlation
Senographe ds, by GE Healthcare (2 mentions)
Aixplorer, by SuperSonic Imagine (1 mentions)
Hdi 5000, by Philips (1 mentions)
Aplio i800, by Canon (1 mentions)
Gadovist, by Bayer (1 mentions)
Mammomat inspiration, by Siemens (1 mentions)
Selenia dimensions mammography system, by Hologic (1 mentions)
Mammomat novation dr, by Siemens (1 mentions)
Aplio i700, by Canon (1 mentions)
12 protocols using lorad selenia
1
Multimodal Breast Imaging Evaluation
2
Mammography System Simulation and Clinical Use
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The mammography system used both in the simulations and in the clinical exercise made use of an Hologic Lorad Selenia with an a-Se flat panel detector (Hologic, Inc; Bedford, Massachusetts, USA). The system parameters are defined in Table 1.
3
Multimodal Imaging for Neoadjuvant Chemotherapy
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Both MG and MRI examinations were performed in all 29 patients before and after NAC. Mammography was performed using Lorad Selenia (Hologic, Bedford, MA, USA) and Mammomat Inspiration (Siemens Medical Solutions Erlangen, Germany). Craniocaudal and mediolateral oblique mammograms were obtained for all patients.
The MRI examination was performed with the patient in the prone position using a 3.0-T scanner (Verio; Siemens Healthcare, Erlangen, Germany) equipped with a dedicated breast coil. The standardized protocol at our institution was performed in the axial plane and consisted of T2-weighted images, diffusion-weighted images, and dynamic series, post-processing subtraction, and maximal intensity projection images. For the dynamic contrast-enhanced studies, one pre-contrast and five post-contrast dynamic series were acquired using a T1-weighted flash three-dimensional (3D) VIBE sequence (TR/TE 4.4/1.7, flip angle 10°, 1.2-mm slice thickness without gap) before and at 10, 70, 130, 190, 250, and 310 s after an injection of 0.1 mmol/kg bodyweight of gadobutrol (Gadovist; Bayer Healthcare, Berlin, Germany).
The MRI examination was performed with the patient in the prone position using a 3.0-T scanner (Verio; Siemens Healthcare, Erlangen, Germany) equipped with a dedicated breast coil. The standardized protocol at our institution was performed in the axial plane and consisted of T2-weighted images, diffusion-weighted images, and dynamic series, post-processing subtraction, and maximal intensity projection images. For the dynamic contrast-enhanced studies, one pre-contrast and five post-contrast dynamic series were acquired using a T1-weighted flash three-dimensional (3D) VIBE sequence (TR/TE 4.4/1.7, flip angle 10°, 1.2-mm slice thickness without gap) before and at 10, 70, 130, 190, 250, and 310 s after an injection of 0.1 mmol/kg bodyweight of gadobutrol (Gadovist; Bayer Healthcare, Berlin, Germany).
4
Breast Cancer Mammography Retrospective Study
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This retrospective study was approved by the Institutional Ethics Review Committee of the China–Japan Friendship Hospital, and the requirement for informed consent was waived for all patients. Between February 2018 and May 2019, 121 consecutive patients with breast cancer were enrolled in this study. The inclusion criteria were as follows: (1) unilateral mass type breast cancer was recruited; (2) preoperative bilateral mammography must be performed; (3) having complete clinical data; (4) having complete pathological data, including postoperative immunohistochemical results. All patients received preoperative mammograms through a digital technique using Lorad Selenia (Hologic Gen-Probe, San Diego, USA). The quantization was set to 14-bit for the full-field digital mammographic images with pixel sizes of 70 µm × 70 µm. Images of the craniocaudal (CC) view and the mediolateral oblique (MLO) view were obtained from mammograms of each patient. A total of 121 single masses were analyzed. 121 patients were randomly divided into the training dataset (n = 85) and the validation dataset (n =36) using statistical software.
5
Mammography Interpretation in Korea
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Digital mammograms were obtained with both craniocaudal and mediolateral oblique views using one of two dedicated mammography devices (Lorad Selenia, Hologic Inc., Danbury, CT, USA). Mammography images were interpreted by three radiologists, one with fellowship training in breast imaging (12 years of experience) and two general radiologists, using the American College of Radiology Breast Imaging Reporting And Data System (ACR BI-RADS) parenchymal density and final assessment categories [18] . The mammograms were interpreted by one radiologist, as double-reading is not routine for mammography interpretation in Korea. Prior examinations, if available, was used for comparison during mammography interpretation. Interpretation results recorded in the radiologic reports were used for data analysis.
6
Volumetric Breast Density Changes During Neoadjuvant Chemotherapy
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Mammograms were obtained using a full-field digital mammography unit (Lorad Selenia; Hologic). Standard mediolateral oblique and craniocaudal views of the bilateral breasts were obtained for all patients at the time of diagnosis (pre-NCT value) and after the completion of NCT (post-NCT value). Vbd was automatically calculated using the Quantra software (version 2.0; Hologic), which provided the volumes of the total breast tissue (Vb, cm3), fibroglandular tissue (Vfg, cm3), Vbd (%), and quantized density (Qabd). The pre-NCT and post-NCT values of the non-diseased breast were used for analysis. To focus on the changes in volumetric density during NCT, ΔVbd was calculated as post-NCT Vbd minus pre-NCT Vbd. ΔVbd% was calculated using the following formula: (ΔVbd/pre-NCT Vbd) × 100 (%). As the 25 and 75 percentiles of ΔVbd% in our study population were -18.9% and 16.7%, respectively, we used similar but arbitrarily chosen cutoff values for ΔVbd (-20% and 20%) to divide patients into the decreased, stable, and increased groups (ΔVbd% < -20%, -20% ≤ ΔVbd% ≤ 20%, and ΔVbd% > 20%, respectively) (Fig. 2 ).
7
Mammographic Features of DCIS: Retrospective Review
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One of two dedicated digital mammography units was used for the mammography examinations (Senographe DS, GE Medical Systems; Lorad Selenia, Hologic). Standard mediolateral oblique (MLO) and craniocaudal (CC) mammograms and magnification views with 90° lateral and craniocaudal projections, if required, were obtained for all patients.
One board-certified, breast-dedicated radiologist with 14 years of experience in breast imaging (J.H.Y.) retrospectively reviewed the baseline mammograms that were collected routinely before biopsy. Mammographic features of abnormalities that correlated to the biopsy-proven DCIS were categorized into the following four categories: (1) mammographically occult (DCIS detected on supplemental ultrasound (US)), (2) mass/asymmetry/distortion, (3) calcifications only, and (4) combined mass/asymmetry/distortion with calcifications (referred to as “combined features”). Final assessments according to the American College of Radiology Breast Imaging Reporting And Data System (ACR BI-RADS) [21 ] were also determined by the radiologist during the retrospective review. The radiologist was blinded to the final surgical diagnosis.
One board-certified, breast-dedicated radiologist with 14 years of experience in breast imaging (J.H.Y.) retrospectively reviewed the baseline mammograms that were collected routinely before biopsy. Mammographic features of abnormalities that correlated to the biopsy-proven DCIS were categorized into the following four categories: (1) mammographically occult (DCIS detected on supplemental ultrasound (US)), (2) mass/asymmetry/distortion, (3) calcifications only, and (4) combined mass/asymmetry/distortion with calcifications (referred to as “combined features”). Final assessments according to the American College of Radiology Breast Imaging Reporting And Data System (ACR BI-RADS) [21 ] were also determined by the radiologist during the retrospective review. The radiologist was blinded to the final surgical diagnosis.
8
Digital Mammography Protocol for Breast Screening
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Mammography (MMG) was performed using a full-field digital mammography unit equipped with 24 cm × 29 cm amorphous selenium detectors of 70-μm pixel size (Lorad Selenia, Hologic, Danbury, CT). Two standard views, medio-lateral oblique and cranio-caudal, were acquired for each breast. All mammograms were evaluated on a set of two monochrome 5-megapixel liquid crystal displays (MFGD5621HD, 2,048×2,560 pixels, 21.3 inch; BARCO, Torhout, Belgium) with image viewer software (Mammoread; TOYO Corporation, Tokyo, Japan).
9
Full-field Digital Mammography Protocol
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Mammography was performed using a full-field digital mammography unit equipped with a 24 × 29-cm amorphous selenium detector at 70-μm pixels (Lorad Selenia, Hologic, Danbury, CT, USA). The medio-lateral oblique and cranio-caudal views were acquired for each breast. All mammograms were evaluated on two monochrome 5-megapixel liquid crystal displays (MFGD5621HD, 2,048 × 2,560 pixels, 21.3 inch; BARCO, Torhout, Belgium) using image viewer software (Mammoread; TOYO Corporation, Tokyo, Japan).
10
Breast Cancer Screening Protocol
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Patients attended the National Health Service Breast Screening Program (NHSBSP) between February 2010 and September 2019 at sites that are part of the OPTIMAM mammography image database (OMI-DB, see supplementary material and Halling-Brown et al. [15 (link)]). The source data are accessible for other research groups. Our manuscript reports new work that has not been undertaken or reported previously using data from this database [16 ]. Patients were eligible for inclusion if they had standard four-view mammography of ‘for presentation’ type and had normal or malignant episode outcomes. Screening episodes were excluded if the mammograms were not from Hologic machines, or if the woman was not 46–74 year at the time of their screening mammogram, or the woman had breast implants. All mammograms were taken using Hologic Lorad Selenia or Hologic Selenia Dimensions Mammography Systems, following requirements for the MIRAI algorithm [17 ].
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