Anatabine free base

Manufactured by WuXi AppTec

Sourced in China

Anatabine free base is a chemical compound that can be used as a reagent in laboratory settings. It is a colorless crystalline solid that is soluble in organic solvents. The core function of anatabine free base is to serve as a precursor or intermediate in chemical synthesis reactions, though its specific applications may vary depending on the research or experimental context.

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Lab products found in correlation

Nicotine free base, by Merck Group (2 mentions) Cotinine free base, by Merck Group (2 mentions) Scopolamine hydrobromide, by Merck Group (1 mentions) Buspirone hydrochloride, by Bio-Techne (1 mentions) Acetylcholine bromide, by Merck Group (1 mentions) Nornicotine, by Merck Group (1 mentions)

2 protocols using anatabine free base

Nicotine, Cotinine, and Anatabine Characterization

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(‒)-Nicotine free base (CAS No. 54-11-5), (‒)-cotinine free base (CAS No. 486-56-6), and (‒)-scopolamine hydrobromide (CAS No. 6533–68‒2) were purchased from Sigma-Aldrich (St. Louis, MO, USA). (±)-Anatabine free base (purity > 95% by HPLC) was custom-synthesized by WuXi AppTec (Shanghai, China). The nAChR agonist activities of nicotine, cotinine, and anatabine are indicated in Fig. 1 for reference^{18 (link)}.Figure 1

α4β2 and α7 nAChR EC₅₀ values of nicotine, cotinine, and anatabine. α4β2 and α7 nAChRs EC₅₀ values were determined in Chinese hamster ovarian (CHO) cells overexpressing the respective human nAChRs as reported by Alijevic et al.^{18 (link)}. Nicotine and anatabine are potent, while cotinine is a weak α4β2 nAChR agonist. Nicotine is also a weak α7 agonist. NA not available due to no or low activity.

Callahan P.M., Terry AV J.r., Peitsch M.C., Hoeng J, & Koshibu K. (2021). Differential effects of alkaloids on memory in rodents. Scientific Reports, 11, 9843.

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Synthesis and Characterization of Nicotinic Compounds

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Acetylcholine bromide (CAS No. 66-23-9), (–)-nicotine free base (CAS No. 54-11-5), (–)-cotinine free base (CAS No. 486-56-6), and ( ±)-nornicotine (CAS No. 5746-86-1) were purchased from Sigma-Aldrich (St. Louis, MO, USA). ( +)-Anabasine hydrochloride (CAS No. 53912-89-3), buspirone hydrochloride (CAS No. 33386-08-2), and metanicotine oxalate (CAS No. 220662-95-3) were purchased from Tocris Bioscience (Bio-Techne^®, Minneapolis, MN, USA). ( ±)-Anatabine free base, AZD1446, and (S)-N-methylanatabine dihydrochloride were custom synthesized by WuXi AppTec (all: purity ≥ 95%; Shanghai, China).

Alzualde A., Jaka O., Latino D.A., Alijevic O., Iturria I., de Mendoza J.H., Pospisil P., Frentzel S., Peitsch M.C., Hoeng J, & Koshibu K. (2021). Effects of nicotinic acetylcholine receptor-activating alkaloids on anxiety-like behavior in zebrafish. Journal of Natural Medicines, 75(4), 926-941.

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