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2 protocols using benzydamine n oxide

1

Comprehensive Compound Library Analysis

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Albendazole, 1-OH-albendazole, benzydamine, phenacetin, acetaminophen, bufuralol, flutamide, diclofenac, and paclitaxel were obtained from the AstraZeneca compound library. 2-OH-bupropion, 1-OH-bufuralol, 1-OH-midazolam, 4-OH-midazolam, 4-OH-mephenytoin, 4-OH-diclofenac, 2-OH-flutamide, benzydamine N-oxide, 4-nitrocatechol, β-Nicotinamide adenine dinucleotide hydrate (NADPH) and DMSO were obtained from Sigma (St. Louis, MO, USA). Bupropion was obtained from Kemprotec Limited (Smailthorn, Carnforth, United Kingdom), midazolam from Lipomed (Cambridge, MA, USA), 6α-OH-paclitaxel from EMD Chemicals (San Diego, CA, USA), and S-mephenytoin from Toronto Research Chemicals (Toronto, ON, Canada). P-nitrophenol and potassium dihydrogen phosphate were obtained from Thermo Fisher Scientific (Gothenburg, Sweden) and dipotassium hydrogen phosphate and magnesium chloride were obtained from Merck (Kenilworth, NJ, USA). Formic acid (98–100%, analytical grade) was obtained from Merck (Darmstadt, Germany), acetonitrile from Rathburn (Walkerburn, UK), and ethanol from CCS Healthcare AB, Borlänge, Sweden. Deionized water was produced in an ELGA purification system (High Wycombe, UK).
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2

Comprehensive Analytical Protocol

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NADPH and triethylamine were purchased from Merck. Methanol and acetonitrile were purchased from Appenlab (Italy). Salts, ethylacetate, phosphoric acid, benzydamine, benzydamine Noxide, sulindac sulfide, sulindac, tamoxifen and all bacterial growth media were purchased from Sigma Aldrich (Italy). tamoxifen N-oxide was purchased from Toronto Research Chemicals Inc. (Canada).
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