Blood samples were collected in 3 mL tubes containing buffered trisodium citrate 3.2% (S-Monovette; Sarstedt AG, Nürmbrecht, Germany), with a citrate:blood volume ratio of 1:9. After centrifugation (2500 G for 10 min), the DOAC concentration was measured in platelet-poor plasma on STA Compact Max 3 (Diagnostica Stago, Asnieres, France) device using specific chromogenic tests. For dabigatran, STA-ECA II (Diagnostica Stago, Asnieres, France) was used. For the measurement of the direct factor Xa-inhibitors apixaban, edoxaban, and rivaroxaban, the STA-Liquid Anti-Xa assay with dedicated calibrators (Diagnostica Stago, Asnieres, France) were applied. Moreover, the standard coagulation test prothrombin time (PT, reference limit 11–16.1 s; STA-NeoPTimal; Diagnostica STAGO, Asnieres, France) and activated partial thromboplastin time (aPTT, reference limit 24–35 s; Cephascreen; Diagnostica STAGO, Asnieres, France) were measured with the same device.
Sta neoptimal
Manufactured by Diagnostica Stago
Sourced in France
The STA-NeoPTimal is a laboratory instrument designed for the analysis of prothrombin time (PT) and activated partial thromboplastin time (aPTT) coagulation tests. It utilizes optical detection technology to measure the clotting time of plasma samples.
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Lab products found in correlation
Sta compact max3, by Diagnostica Stago (1 mentions)
Sta eca 2, by Diagnostica Stago (1 mentions)
S monovette, by Sarstedt (1 mentions)
Sta liquid anti xa assay, by Diagnostica Stago (1 mentions)
Staclot la, by Diagnostica Stago (1 mentions)
Sta r evolution analyzer, by Diagnostica Stago (1 mentions)
Hemoclot thrombin inhibitors, by Hyphen Biomed (1 mentions)
Ptt la, by Diagnostica Stago (1 mentions)
Sta ptt automate, by Diagnostica Stago (1 mentions)
Sta liquid anti xa, by Diagnostica Stago (1 mentions)
2 protocols using sta neoptimal
1
Measurement of Direct Oral Anticoagulants
2
Coagulation Assays for Anticoagulant Monitoring
Check if the same lab product or an alternative is used in the 5 most similar protocols
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LAC testing was performed according to the ISTH guidelines by a three‐step (screening‐mixing‐confirmatory) method using a dRVVT‐ and aPTT‐based test system,14 using STA‐Staclot dRVV Screen, STA‐Staclot dRVV Confirm, PTT‐LA, and Staclot LA reagents (Diagnostica Stago), as previously described.37 Results are expressed as normalized clotting ratio (NCR) or a difference of CT for Staclot LA aPTT.14 , 37 Apixaban, rivaroxaban, and edoxaban levels were measured using a chromogenic anti‐Xa assay (STA‐Liquid anti‐Xa; Diagnostica Stago) calibrated for the corresponding DOAC. A diluted thrombin time (TT) assay (Hemoclot Thrombin Inhibitors, Hyphen BioMed) was used for measurement of dabigatran concentrations. Routine coagulation parameters, PT and aPTT, were determined using STA‐NeoPtimal and STA‐PTT Automate (Diagnostica Stago), respectively. Heparins were measured by a chromogenic anti‐Xa assay (STA‐Liquid anti‐Xa, Diagnostica Stago). Intrinsic and extrinsic coagulation factors were measured by one‐stage assays using STA‐(immuno)deficient plasma and C.K. Prest or STA‐NeoPtimal, respectively. All analyses were performed on a STA‐R Evolution analyzer (Diagnostica Stago).
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