Female nude hsd athymic nude foxn1nu mice

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The female nude (Hsd:Athymic Nude-Foxn1nu) mice are a laboratory animal model. They are characterized by a genetic mutation that results in a lack of functional thymus gland, leading to a compromised immune system. These mice are commonly used in research applications that require an immunodeficient animal model.

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3 protocols using female nude hsd athymic nude foxn1nu mice

1

Nude Mouse Tumor Growth Protocol

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The Animal Experimentation Committee at the Academic Medical Center in Amsterdam has approved all in vivo experiments (DEC103181 and DEC102348) and all animal experiments were performed according to the national guidelines. Female nude (Hsd:Athymic Nude-Foxn1^nu) mice (6–12 wk old) were obtained from Envigo. Animals were randomly assigned to experimental groups; no blinding was applied for these experiments. Animal exclusion was performed when no tumor growth appeared.

van der Heijden M., Miedema D.M., Waclaw B., Veenstra V.L., Lecca M.C., Nijman L.E., van Dijk E., van Neerven S.M., Lodestijn S.C., Lenos K.J., de Groot N.E., Prasetyanti P.R., Arricibita Varea A., Winton D.J., Medema J.P., Morrissey E., Ylstra B., Nowak M.A., Bijlsma M.F, & Vermeulen L. (2019). Spatiotemporal regulation of clonogenicity in colorectal cancer xenografts. Proceedings of the National Academy of Sciences of the United States of America, 116(13), 6140-6145.

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2

In Vivo Xenograft Tumor Experiments

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The study is compliant with all relevant ethical regulations regarding animal research. All in vivo experiments of this study were approved by the Animal Experimentation Committee at the Academic Medical Center in Amsterdam (DEC103141) and performed according to national guidelines. Female nude (Hsd:Athymic Nude-Foxn1^nu) mice (6-12 weeks old) were obtained from Envigo. NOD-scid IL2rγnull mice (NSG; NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ) were bred in our facility. Animals were randomly assigned to experimental groups, no blinding was performed during these experiments. Animals were only excluded from analyses when no tumours appeared. Animal sample sizes were estimated on the basis of previous work1 (link).

Lenos K.J., Miedema D.M., Lodestijn S.C., Nijman L.E., van den Bosch T., Romero Ros X., Lourenço F.C., Lecca M.C., van der Heijden M., van Neerven S.M., van Oort A., Leveille N., Adam R.S., de Sousa E Melo F., Otten J., Veerman P., Hypolite G., Koens L., Lyons S.K., Stassi G., Winton D.J., Medema J.P., Morrissey E., Bijlsma M.F, & Vermeulen L. (2018). Stem cell functionality is microenvironmentally defined during tumour expansion and therapy response in colon cancer. Nature cell biology, 20(10), 1193-1202.

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3

In Vivo Xenograft Tumor Experiments

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The study is compliant with all relevant ethical regulations regarding animal research. All in vivo experiments of this study were approved by the Animal Experimentation Committee at the Academic Medical Center in Amsterdam (DEC103141) and performed according to national guidelines. Female nude (Hsd:Athymic Nude-Foxn1^nu) mice (6-12 weeks old) were obtained from Envigo. NOD-scid IL2rγnull mice (NSG; NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ) were bred in our facility. Animals were randomly assigned to experimental groups, no blinding was performed during these experiments. Animals were only excluded from analyses when no tumours appeared. Animal sample sizes were estimated on the basis of previous work1 (link).

Lenos K.J., Miedema D.M., Lodestijn S.C., Nijman L.E., van den Bosch T., Romero Ros X., Lourenço F.C., Lecca M.C., van der Heijden M., van Neerven S.M., van Oort A., Leveille N., Adam R.S., de Sousa E Melo F., Otten J., Veerman P., Hypolite G., Koens L., Lyons S.K., Stassi G., Winton D.J., Medema J.P., Morrissey E., Bijlsma M.F, & Vermeulen L. (2018). Stem cell functionality is microenvironmentally defined during tumour expansion and therapy response in colon cancer. Nature cell biology, 20(10), 1193-1202.

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