SD-OCT images were obtained with a Spectralis® OCT machine (Spectralis® Family Acquisition Module, version 4.0.2.0; Heidelberg Engineering) and Heidelberg Eye Explorer (version 1.6.1.0; Heidelberg Engineering) before induction therapy and every month thereafter. Horizontal and vertical scans of the macula were recorded for each eye. The measurements were performed under pupillary dilation. CRT was defined as the distance between the vitreoretinal border and the edge of the retinal pigment epithelial cells. We determined the presence or absence of pigment epithelial detachment (PED), IRF, and SRF. These procedures were performed within a foveal area of 1.8-mm diameters, which is considered to be the macula.15 VA was measured with a Landolt C chart and then converted to a logarithm of the minimum angle of resolution (logMAR) equivalent. Clinical characteristics, including age, sex, greatest linear dimension (GLD), and disease subtypes such as typical AMD, polypoidal choroidal vasculopathy (PCV), and retinal angiomatous proliferation, were also reviewed and analyzed. We also studied the possible pretreatment factors (age, sex, subtype, VA, CRT, GLD, PED, IRF, SRF, and treatment history) that would affect the response to or dependence on aflibercept.
Spectralis oct machine
Manufactured by Heidelberg Engineering
Sourced in Germany
The Spectralis OCT machine is an optical coherence tomography (OCT) device developed by Heidelberg Engineering. It is designed to capture high-resolution, three-dimensional images of the eye's structures, including the retina, optic nerve, and anterior segment. The Spectralis OCT uses a scanning laser ophthalmoscope to provide a detailed, cross-sectional view of the eye, enabling clinicians to assess and monitor a variety of ocular conditions.
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Lab products found in correlation
3 protocols using spectralis oct machine
1
Longitudinal Retinal Imaging and Visual Outcomes
2
Macaque Monkey Retinal Layers Analysis
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An OCT image of each monkey was taken twice before the MNU injection and before the sacrifice using a Spectralis OCT machine (Heidelberg Engineering GmbH, Heidelberg, Germany). The OCT image was acquired in the 55° range with the macular region at the center of the image. The image acquisition and analysis were described in our previous study [19 (link)]. The area of the macaque monkey’s fovea and macula were determined to be 0 to 0.6 mm per degree and 0.6 to 2 mm per degree, respectively [14 (link)]. Three nuclear layers in the retina, the ganglion cell layer (GCL), the inner nuclear layer (INL), and the outer nuclear layer (ONL), were identified by three dark layers on the OCT image.
3
OCT and Fluorescein Angiography Imaging Protocol
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OCT imaging was performed using a Spectralis OCT machine (Heidelberg Engineering, Heidelberg, Germany), and the following parameters were documented for all eyes: central sub-field thickness (CST), the presence of retinal pigment epithelium (RPE) alterations, and sub-foveal choroidal thickness (SCT) using the caliber option defined as "the distance extending from the outer portion of the hyperreflective line corresponding to the retinal pigment epithelium (RPE) to the hyporeflective line corresponding to the sclerochoroidal interface" [21 (link)].
Patients who have received simultaneous fundus fluorescein angiography (FA) imaging using the Heidelberg Retinal Angiogram (HRA-2; Heidelberg Engineering GmBH, Dossenheim, Germany) were reviewed for the presence and location of actively leaking hot spot(s).
Patients who have received simultaneous fundus fluorescein angiography (FA) imaging using the Heidelberg Retinal Angiogram (HRA-2; Heidelberg Engineering GmBH, Dossenheim, Germany) were reviewed for the presence and location of actively leaking hot spot(s).
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