Inveon multimodality scanner

Manufactured by Siemens

Sourced in United States

The INVEON Multimodality scanner is a compact and versatile imaging system designed for small animal research. It combines multiple imaging modalities, including Positron Emission Tomography (PET), Computed Tomography (CT), and Single-Photon Emission Computed Tomography (SPECT), within a single platform. The system is capable of acquiring high-resolution images of small animals, providing researchers with a comprehensive tool for preclinical studies.

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Lab products found in correlation

Inveon research workplace software, by Siemens (4 mentions) Inveon multimodality pet ct scanner, by Siemens (1 mentions) Pargyline, by Merck Group (1 mentions)

10 protocols using inveon multimodality scanner

Quantitative PET Imaging of Doxorubicin Uptake

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For qualitative assessment of tracer uptake with in vivo microPET imaging, mice (2 each at 1, 6, and 12 weeks after doxorubicin treatment) were anesthetized with 3% isoflurane/97% oxygen and placed on a heated scanner bed in an INVEON Multimodality scanner (Siemens) for imaging 1 hour after injection of 200 μCi of 18F-CP18 via intravenous tail vein injection. A CT scan was performed (80 kVp and images were reconstructed from 270 projections) for anatomic registration followed by a 15-minute static PET scan with an INVEON Multimodality scanner (Siemens Knoxville, TN). Images were reconstructed using filtered back projections without attenuation, scatter, or dead-time corrections with a pixel size of 0.77×0.77×0.79 mm. PET and CT images were coregistered on the basis of anatomic landmarks using an Inveon Research Workplace software (Siemens, Knoxville, TN).

Su H., Gorodny N., Gomez L.F., Gangadharmath U., Mu F., Chen G., Walsh J.C., Szardenings K., Kolb H.C, & Tamarappoo B. (2015). Noninvasive Molecular Imaging of Apoptosis in a Mouse Model of Anthracycline-Induced Cardiotoxicity. Circulation. Cardiovascular imaging, 8(2), e001952.

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High-Resolution Small Animal CT Imaging

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Imaging was performed on an Inveon Multimodality scanner (Siemens Medical Solutions USA, Malvern, PA, USA), in which CT rays are generated by 80 kV peak voltage difference between cathode and tungsten target at 0.5 mA current and 200 milli second exposure time. The CT field of view was 5.5 cm by 8.5 cm with an overall resolution without magnification of 50 microns. After each acquisition, data were sorted into 3D sinograms, and images were reconstructed using a 2D-ordered subset expectation maximization algorithm. Data were corrected for deadtime counting losses, random coincidences, and the measured non-uniformity of detector response.

Maitra R., Thavornwatanayong T., Venkatesh M.K., Chandy C., Vachss D., Augustine T., Guzik H., Koba W., Liu Q, & Goel S. (2019). Development and Characterization of a Genetic Mouse Model of KRAS Mutated Colorectal Cancer. International Journal of Molecular Sciences, 20(22), 5677.

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Pixelated Detector Normalization for SPECT

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Test data were acquired for a 30 mm diameter syringe filled with Tc-99m solution on a Siemens Inveon Multi-Modality scanner with single-pinhole (1-MGP-1.0) and five-pinhole (5-MWB-1.0) collimators, respectively (neither on the same day nor with the same syringe). A routine normalization was acquired with Tc-99m point-source at 360 mm distance. For the single-pinhole study, the projection data summed over all views were checked for the dark cross artifacts (Fig. 2) before and after applied the conventional normalization and the normalization by the proposed method, respectively. The test data were reconstructed by the proposed method which models the pixelated detector in the projection matrix. For comparison, the data were normalized by the normalization maps obtained by point-source at 360 mm distance and reconstructed by the OSEM with the same number of iterations and subsets.

Feng B, & Zeng G.L. (2014). Modeling of Pixelated Detector in SPECT Pinhole Reconstruction. IEEE transactions on nuclear science, 61(2), 888-893.

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Ex-vivo Micro-PET Imaging of Aortic Plaque

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For ex-vivo micro-PET imaging, mice were euthanized and a laparotomy was performed 1hr after injection of the radiotracer. Transcardial perfusion of the aorta was performed with 100ml of normal saline. The entire aorta was explanted from 3 Athero, control and WT mice after tracer infusion and PET image acquisition was performed. An INVEON Multimodality scanner (Siemens) was used for ex vivo micro-PET imaging. The extracted aorta was scanned for 30 minutes. Images were reconstructed using filtered back projections without attenuation, scatter or dead-time corrections. The aorta was stained with oil-red-O (ORO) for visualization of plaque (as described below) and micro-PET images were visually coregistered with digital ORO stained images. Quantification of tracer uptake was performed in regions of interest (ROI) in the aorta containing plaque and the corresponding activity values were determined using the INVEON Research Workplace software (Siemens, Knoxville, TN). All values were expressed as a ratio of %ID/g of the plaque containing aortic wall to normal appearing aortic wall.

Su H., Gorodny N., Gomez L.F., Gangadharmath U.B., Mu F., Chen G., Walsh J.C., Szardenings K., Berman D.S., Kolb H.C, & Tamarappoo B.K. (2014). Atherosclerotic plaque uptake of a novel integrin tracer 18F-Flotegatide in a mouse model of atherosclerosis. Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 21(3), 553-562.

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Ex vivo microPET Imaging of Mice

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For ex vivo microPET imaging, mice were euthanized and a laparotomy was performed 1 hour after injection of 200 μCi of 18F-CP18. An INVEON Multimodality scanner (Siemens) was used for micro-PET imaging for 30 minutes. Quantification of tracer uptake was performed by visually drawing regions of interest (ROI) measuring 2.0 mm³ in the heart, and the corresponding activity values in %ID/g were quantified using the INVEON Research Workplace software (Siemens).

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PET Imaging of FDG Uptake in Injury

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Prior to injury and at 1 and 14 dpi, PET imaging was performed to assess FDG (1.5-2 mCi injection) uptake, as previously described [17 (link)], with a 70-minute uptake period and a static 30-minute PET scan using a Siemens Inveon Multimodality scanner (Siemens Medical Solutions, Erlangen, Germany).
Images were analyzed using Siemens Inveon Research Workplace (IRW) software, version 4.2, as previously described [17 (link)]. To avoid biases introduced due to partial-volume effects, the PET data were reconstructed using iterative algorithm (ordered subset expectation maximization) and the ROI’s drawn were more than 3 times (ROI size = 26mm³) (von Leden et al., 2016) the scanner intrinsic resolution (1.4mm × 3 = 4.2mm³). Further, to restrict influence of FDG uptake in surrounding injured muscle tissue of the surgery site, ROIs were restricted to within the bony structures, as previously described [17 (link)].

von Leden R.E., Moritz K.E., Bermudez S., Jaiswal S., Wilson C.M., Dardzinski B.J, & Byrnes K.R. (2018). Aging alters glucose uptake in the naïve and injured rodent spinal cord. Neuroscience letters, 690, 23-28.

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Ferret PET/CT Imaging of 18F-FDG Lymphatic Uptake

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Ferrets were imaged pre- and post-infection as indicated in the text, using positron emission tomography (PET) and computerized tomography (CT). Scans were obtained using a custom-built ferret pallet compatible with the ASI Animal Handling System (ASI Instruments, Inc., Warren, MI) of the Siemens Inveon Multimodality scanner (Siemens Healthcare GmbH, Erlangen, Germany). In brief, anesthetized animals received a subcutaneous intra-digital injection (in the right hind-foot) of ¹⁸F-FDG (100–150 uCi), and PET data was acquired in list mode for 60 minutes. The frames were reconstructed for kinetic analysis, without scatter or attenuation correction, using a 3D-OSEM/MAP algorithm. Immediately following the PET scan, CT data was acquired. The PET and CT datasets were manually registered using fiducial markers and displayed as maximum intensity projection (MIP) images. Anatomical Regions-of-Interest (ROIs) were determined using the CT images, and the kinetics of ¹⁸F-FDG uptake through the lymphatic vasculature is reported as a percent of total injected tracer contained within the ROI over time.

Jackson-Thompson B.M., Kim S.Y., Jaiswal S., Scott J.R., Jones S.R., Morris C.P., Fite J.J., Laurie K., Hoy A.R., Dardzinski B.J, & Mitre E. (2018). Brugia malayi infection in ferrets – A small mammal model of lymphatic filariasis. PLoS Neglected Tropical Diseases, 12(3), e0006334.

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Multimodal Imaging of Atherosclerosis in Mice

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CT angiography was performed in 3 control mice and 3 Athero mice fed a high fat diet. Approximately 0.3ml of iodinated contrast (Fenestra, Advanced Research Technologies, Saint Laurent, Canada) was injected by tail vein and CT images were acquired with An INVEON Multimodality PET/CT scanner (Siemens, Knoxville, TN). Image acquisition was performed at 80kVp and images were reconstructed from 270 projections. For in vivo microPET imaging, mice were euthanized, 1 hr after injection of radiotracer prior to PET-CT image acquisition with a INVEON Multimodality scanner (Siemens). Images were reconstructed using filtered back projections without attenuation, scatter or dead-time corrections with a pixel size of 0.77×0.77×0.79mm. PET and CT images were coregistered on the basis of anatomic landmarks using an Inveon Research Workplace software (Siemens, Knoxville, TN).

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In Vivo PET Imaging of Rat Brain

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All procedures in this study followed the guidelines of the Institutional Animal Care and Use Committee of the University of the Sciences, Philadelphia, PA. A Siemens Inveon Multimodality Scanner was used for micro-PET/computed tomography (CT) imaging. Male wild-type Sprague-Dawley rats (128 ± 58 g) were anesthetized with 3% isoflurane with oxygen. Rats were administered [¹⁸F]fluoroethyl-harmol or [¹⁸F]flortaucipir via tail vein injection (7.4-14.8MBq [200–400 μCi] in a total volume of 200 μL). For blocking studies, rats were pre-treated with pargyline (Sigma-Aldrich, 50 mg/kg i.p.) 30 min prior to scans; control rats were pre-treated with 0.9% saline injection (Hospira, i.p.). A short high-resolution CT scan was first conducted for anatomical registration, followed by a 120-min dynamic PET scan. PET images were generated for each minute of the acquisition time. Uptake of the tracers was determined by visually drawing regions of interest based on the fused PET/CT images, and corresponding activity values were determined using Inveon Research Workplace software. All values are represented as % injected dose per gram (ID/g). A total of 6 rats were studied (3 control, 3 pre-treated) for [¹⁸F]fluoroethyl-harmol and 8 rats for [¹⁸F]flortaucipir (4 control, 4 pre-treated).

Wright J.P., Goodman J.R., Lin Y.G., Lieberman B.P., Clemens J., Gomez L.F., Liang Q., Hoye A.T., Pontecorvo M.J, & Conway K.A. (2022). Monoamine oxidase binding not expected to significantly affect [18F]flortaucipir PET interpretation. European Journal of Nuclear Medicine and Molecular Imaging, 49(11), 3797-3808.

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In Vivo FDG-PET Imaging of Tumor-Bearing Mice

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FDG-PET analysis was performed at the Lurie Family Imaging Center of the Center for Biomedical Imaging in Oncology (CBIO/LFIC) DFCI as previously reported (McCall et al. 2015). Four DF86-Luc tumor bearing mice were imaged at 36 days post-implantation by intraperitoneal injection by [¹⁸F]-FDG-PET/CT. [¹⁸F]-FDG was manufactured by a commercial radiopharmaceutical manufacturer (PETNET Solutions Inc) and supplied in ethanol-stabilized sodium chloride solution. All images were acquired using an Inveon Multi-Modality scanner (Siemens Medical Solutions USA, Inc), a small-animal PET/CT system.

Liu J.F., Palakurthi S., Zeng Q., Zhou S., Ivanova E., Huang W., Zervantonakis I.K., Selfors L.M., Shen Y., Pritchard C.C., Zheng M., Adleff V., Papp E., Piao H., Novak M., Fotheringham S., Wulf G.M., English J., Kirschmeier P., Velculescu V., Paweletz C., Mills G.B., Livingston D., Brugge J.S., Matulonis U, & Drapkin R. (2016). Establishment of patient-derived tumor xenograft models of epithelial ovarian cancer for pre-clinical evaluation of novel therapeutics. Clinical cancer research : an official journal of the American Association for Cancer Research, 23(5), 1263-1273.

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