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6 protocols using oleic acid

1

Leflunomide Lipid Nanoparticle Formulation

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Leflunomide was obtained as a gift sample from aarti pharmaceuticals, mumbai. Stearic acid as solid lipid purchased from nice chemicals, kerala, oleic acid as liquid lipid & tween 80 as surfactant was purchased from loba chemie pvt. Ltd. mumbai. Poloxamer 188 used as surfactant was purchased from research lab fine chem industries, mumbai. Methanol from nice chemicals, kerala. Adult female Sprague dawley rats weighing 200-250 g was obtained from central lab animal facility, AIMS, kochi.
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2

Solubility Enhancement of Drugs

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EA was purchased from Yucca Enterprises Pvt. Ltd, Mumbai, India. Capmul MCM C8, and captex 500 were gifted by Abitec Corp., USA. Capryol 90, labrafil M 2125 CS, labrafil M 2130 CS, labrafac CC, labrasol, lauroglycol FCC, transcutol P were kindly gifted by Gattefosse, France. Oleic acid, tween 80, tween 20, span 20, propylene glycol, PEG 400 and PEG 200 were purchased from Loba Chemie Pvt. Ltd., Mumbai. Cremophor RH 40 was a gift from BASF, Germany.
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3

Phenytoin-Oleic Acid Nanoparticles for Brain Delivery

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Phenytoin sodium API was purchased from Sigma Aldrich, St. Louis, MO, USA, and was used as received. Oleic acid was purchased from Loba Chemie (Mumbai, India). Cholesterol A.R and Pluronic-F-188 (Poloxamer) were procured from Nice Chemicals (Kochi, India). Dialysis membrane (12,000–14,000 Dalton) was from Sigma Aldrich (Bangalore, India). Fibroblast (L929) cells were purchased from National Center for Cell Sciences, Pune, India, and Human Brain Capillary Endothelial Cells (HBCEC)[ATCC-CRL-3245] were received from LGC Promochem India Pvt. Ltd. (Bangalore, India). Ethanol, acetone, potassium di hydrogen ortho phosphate, ortho phosphoric acid, diethyl ether, high pressure liquid chromatography (HPLC) grade mEthanol, acetone and acetonitrile were purchased from Merck Chemical Company, Mumbai, India.
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4

Nevirapine Formulation Development

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Nevirapine was obtained from Cipla Ltd., Pune. Oleic acid was obtained from LOBA Chemie Pvt. Ltd., Mumbai. Tween 20 was obtained from S D Fine Chemicals Ltd., Mumbai. Polyethylene glycol (PEG) 600 was obtained from S D Fine Chemicals Ltd., Mumbai.
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5

Optimizing Topical Capsaicin Formulations

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Capsaicin was provided as a gift sample by Naturite Agro Products Limited Hyderabad, India. Labrafil M1944CS, Caproyl PGMC, Labrasol was obtained from Gattefosse India Pvt. Ltd, France as a kind gift sample. Span 80, Span 20, Tween 20, isopropyl alcohol, polyethylene glycol (PEG) 200, PEG 400, PEG 600, ethyl oleate, Labrafil M1944CS, labrafac PG, castor oil, oleic acid, isopropyl myristate (IPM), cotton seed oil, soybean oil, & olive oil were procured from LobaChemie Pvt. Ltd, Mumbai, India. Cremophor EL & Cremophor RH40 was provided by BASF, Germany. All other chemicals used were of analytical grade.
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6

Formulation and Evaluation of Lipid-based Drug Delivery

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TNX was obtained as a gift sample from Cipla Ltd, Mumbai, India. Captex 200 and 300 were obtained as a gift sample from Abitech Corporation, USA. Oleic acid, isopropyl myristate (IPM), castor oil, Tween 20 and Tween 40 were procured from Loba Chemie Pvt. Ltd., Mumbai, India. Tween 60 and Tween 80 were purchased from S.D. Fine Chem Ltd., Mumbai, India. All the other chemicals used were of the analytical grade.
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