Gemini tf 2

For AUMC patients, PSMA-PET/CT imaging was performed with [¹⁸F]DCFPyL, a second-generation fluorinated PSMA radiotracer. The scanner used was a Philips Ingenuity (Philips^®, Amsterdam, The Netherlands/MA, USA) PET/CT system. [¹⁸F]DCFPyL was synthesized at the AUMC on-site cyclotron facility according to Good Manufacturing Practices and was supplied to the NCI for imaging purposes. At the NCI, PSMA-PET/CT imaging was performed with both [⁶⁸Ga]Ga-PSMA-11 and [¹⁸F]DCFPyL tracers using a Philips Gemini TF-II or Vereos Digital PET/CT (Philips^®, Amsterdam, The Netherlands/MA, USA). [⁶⁸Ga]Ga-PSMA-11 was radiolabelled in-house using a fully automated system (Scintomics GmbH, Gräfelfing, Germany). At the NCI, PSMA PET/CT scans were performed 60 min post-injection (p.i.) of both ⁶⁸Ga-PSMA-11 and [¹⁸F]DCFPyL PET/CT, while [¹⁸F]DCFPyL PET/CT scans at the AUMC were performed 120 min p.i. [19 (link)]. All PET images were combined with either a low-dose CT (120–140 kV, 40–80 mAs) or a diagnostic CT scan (130 kV, 110 mAs) for anatomical correlation and attenuation correction. All PET images were taken according to the EARL standards and were corrected for scatter, decay and random coincidences [20 (link)].