Tau 2

Manufactured by Quanterix

The Tau 2.0 is a laboratory instrument designed for the quantitative analysis of the tau protein. It utilizes advanced detection technology to accurately measure tau levels in biological samples.

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Lab products found in correlation

To8 50fn, by Sino Biological (1 mentions) Simoa hd 1 analyser, by Quanterix (1 mentions) Nf light assay kits, by Quanterix (1 mentions)

Close spelling variants of this product

Human Total Tau 2.0 kit (3 citations) Tau 2.0 kit (3 citations) Tau 2.0 Sample Diluent (2 citations)

2 protocols using tau 2

Tau Phosphorylation Biomarker Assay Development

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A novel sheep monoclonal antibody, which selectively binds to tau phosphorylated specifically at threonine‐217, was generated, characterized, and used as the capture antibody. A mouse monoclonal antibody (tau12, GenScript Biotech) raised against the N‐terminal region of tau was used for detection. In vitro phosphorylated recombinant full‐length tau‐441 (#TO8‐50FN, SignalChem) was used as the assay calibrator. Blood samples and calibrators were diluted with the assay diluent (Tau 2.0; #101556, Quanterix). Assay validation focused on within‐ and between‐run stability, dilution linearity, spike recovery, and determination of the lowest limit of quantification. Analytical validation followed protocols that were described previously.
²⁹ (link),
³⁰ (link) Assay development work was done at the University of Gothenburg, Sweden. The resulting assay is hereby referred to as UGOT p‐tau217, since it originates from the University of Gothenburg.

Gonzalez‐Ortiz F., Ferreira P.C., González‐Escalante A., Montoliu‐Gaya L., Ortiz‐Romero P., Kac P.R., Turton M., Kvartsberg H., Ashton N.J., Zetterberg H., Harrison P., Bellaver B., Povala G., Villemagne V.L., Pascoal T.A., Ganguli M., Cohen A.D., Minguillon C., Contador J., Suárez‐Calvet M., Karikari T.K, & Blennow K. (2023). A novel ultrasensitive assay for plasma p‐tau217: Performance in individuals with subjective cognitive decline and early Alzheimer's disease. Alzheimer's & Dementia, 20(2), 1239-1249.

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Plasma Biomarkers for Neurodegeneration

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Tau and NfL concentrations were measured in plasma using the Simoa HD-1 Analyser and the "tau-2.0" and "NF-light" assay kits (Quanterix), according to manufacturer's instructions and as described previously 18 . Samples from each diagnostic group were assorted across different loading plates and assay runs. Samples were tested in duplicate, by taking two aliquots from the same plate well. For quality control, data were reviewed after testing and samples without two valid results or with a coefficient of variation (CV) over 15% between duplicates were re-tested. All "tau-2.0" testing kits were from a single batch. "NF-light" kits were taken from 2 separate batches due to a manufacturer issue: a full calibration sample set tested for each batch showed no significant variation between them.

Thompson A.G., Anastasiadis P., Druyeh R., Whitworth I., Nayak A., Nihat A., Mok T.H., Rudge P., Wadsworth J.D.F., Rohrer J.D., Schott J.M., Heslegrave A., Zetterberg H., Collinge J., Jackson G.S., & Mead S. (2020). Evaluation of plasma tau and neurofilament light chain biomarkers in a 12-year clinical cohort of human prion diseases.

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