The scans were performed using a Discovery MI or Discovery D690 (GE Healthcare) PET‐CT system. 68Ga‐DOTA‐TATE was used for somatostatin receptor imaging until 2019. During 2019 there was a shift in production to 68Ga‐DOTA‐TOC at Skåne University Hospital. Both 68Ga‐DOTA‐TATE and 68Ga‐DOTA‐TOC were prepared according to established techniques.24 , 25 , 26 Intravenous injection of an activity of 2.0–2.5 MBq/kg (minimum administered activity 100 MBq and maximum 300 MBq) was followed 60 min later by a PET‐CT scan from mid‐thigh to the top of the head, and the PET acquisition time was 3.0 min to 3 min 15 s per bed position, depending on the radiotracer and the PET‐CT system. Time‐of‐flight and point‐spread function correction were used for both PET‐CT systems. Either a low‐dose CT scan or a diagnostic CT was performed simultaneously for attenuation correction and anatomic correlation. If a recent diagnostic CT was available, only a low‐dose CT was acquired during the PET‐CT examination.
Discovery d690
Manufactured by GE Healthcare
Sourced in United States
The Discovery D690 is a positron emission tomography (PET) system designed for medical imaging. It provides high-resolution, high-sensitivity imaging capabilities for a variety of clinical applications.
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4 protocols using discovery d690
1
PET-CT Somatostatin Receptor Imaging Protocol
2
PET/CT Imaging of Neuroendocrine Tumors
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The PET/CT scans were performed at Skåne University Hospital in Lund using a Discovery MI or Discovery D690 (GE Healthcare, Milwaukee, USA) PET/CT system. In 2019, there was a shift in production from [68Ga]Ga-DOTA-TATE to [68Ga]Ga-DOTA-TOC, which is why both radiotracers were included in this study. The radiotracers were prepared according to established techniques (Bozkurt et al. 2017 (link); Zhernosekov et al. 2007 ; Mueller et al. 2012 (link)). The patient received an intravenous injection of 2.0–2.5 MBq/kg activity (minimum administered activity 100 MBq and maximum 300 MBq), followed by a PET/CT scan approximately 60 min later. The scan covered from the base of the skull to mid-thigh. The PET acquisition time was 3.0–3 min 15 s per bed position, depending on the radiotracer and PET/CT system. Both systems used time-of-flight and point-spread function correction, and either a low-dose CT scan or a diagnostic CT with intravenous contrast (if there were no contraindications) was performed for attenuation correction and anatomic correlation.
3
PET/CT Imaging Protocol for Oncology
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PET/CT images were obtained from a state-of-the-art TOF PET/CT device (Discovery D690, GE Healthcare, Waukesha, WI, USA). The Discovery 690 combines a lutetium yttrium orthosilicate (LYSO) block detector designed PET tomograph with a 64-slice CT scanner. The system further has a powerful computing platform implementing three-dimensional (3-D) PET iterative reconstruction algorithms. These algorithms can account for TOF information [10] . First, a non-contrast whole-body low-dose CT scan was acquired with a tube voltage 120-140 kV, tube current with automated dose modulation 60-440 mA/slice, collimation 64×0.625, pitch 0.984:1, rotation time 0.5 s, coverage speed 78 mm/s, transaxial field of view (FOV) 70 cm and images with a transverse pixel size of 0.625 and a slice thickness of 3.75 mm reconstructed in the axial, coronal and sagittal planes. PET data were then acquired in 3-D TOF mode with scan duration of 2 min per bed position, an overlap of bed positions of 23 % and an axial FOV of 153 mm. PET/CT data sets were reconstructed through AC of the emission data with attenuation maps obtained from the initial low-dose CT scan and were then iteratively reconstructed [matrix size 256×256, Fourier rebinning (VIP mode), VUE Point FX (3-D) with 3 iterations and 18 subsets] [11] .
4
18F-FDG PET/CT Imaging Protocol
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Images were acquired on a time-of-flight PET/CT scanner (Discovery D690; GE Healthcare) with scatter and point-spread-function recovery corrections, 60 min after injection of 18 F-FDG (3.5 MBq/kg) and after the patients had fasted for at least 6 h (PET: 2 min/bed position, 47 slices, 256 • 256 matrix, ordered-subsets expectation maximization, 2 iterations • 24 s; CT: 140 kV, 80-200 SmartmA, 0.5 s/rotation, 3.75-mm thickness). After the PFV apparatus had been installed, PFV PET/CT was performed with a thorax-dedicated (3-bed) acquisition using the same parameters as for PET/CT. Anterior-posterior chest displacement was monitored with Real-Time Position Management, a respiratory gating system supplied by Varian Medical Systems.
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