4-Bromoaniline, purity 98%, was obtained from Aldrich (Poole, UK) and was used as received. Bromobenzene, purity 99%, was also obtained from Aldrich. Solvents for HPLC were of high purity HPLC grade and were obtained from Fisher Scientific UK Ltd. (Loughborough, UK).
4 bromoaniline
Manufactured by Merck Group
Sourced in United Kingdom
4-bromoaniline is a chemical compound with the formula C6H6BrN. It is a white crystalline solid that is used as a precursor in the synthesis of various pharmaceutical and agrochemical products. The primary function of 4-bromoaniline is as a building block for the production of other chemical compounds.
Automatically generated - may contain errors
Lab products found in correlation
4 chloroaniline, by Merck Group (3 mentions)
Cyclohexylamine, by Merck Group (3 mentions)
Triethylamine, by Tedia (2 mentions)
Dimethylformamide, by Carlo Erba (2 mentions)
Sulfaguanidine, by Tokyo Chemical Industry (2 mentions)
Morpholine, by Tokyo Chemical Industry (2 mentions)
4 nitroaniline, by Johnson & Johnson (2 mentions)
M toluidine, by Merck Group (2 mentions)
4 fluoroaniline, by Merck Group (2 mentions)
N hexane, by Carlo Erba (2 mentions)
Ethanol, by Carlo Erba (2 mentions)
Acetone, by Carlo Erba (2 mentions)
Chloroform, by Carlo Erba (2 mentions)
Dimethyl sulfoxide (dmso), by Carlo Erba (2 mentions)
Nano2, by Merck Group (2 mentions)
Bromobenzene, by Merck Group (1 mentions)
Benzoyl peroxide, by Thermo Fisher Scientific (1 mentions)
Avance 3 console, by Bruker (1 mentions)
N butyllithium, by Merck Group (1 mentions)
1 3 dichlorobenzene, by Merck Group (1 mentions)
12 protocols using 4 bromoaniline
1
Synthesis of Brominated Aniline Compounds
2
Synthesis and Characterization of Novel Compounds
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4-Bromobenzyl bromide, 4-bromoaniline, 4-pyridylboronic acid, 1,3-dichlorobenzene, p-tolylmagnesium bromide, n-butyllithium and N-bromosuccinimide were purchased from Aldrich and used as received. Benzoyl peroxide was purchased from Acros and used as received. Compounds 3 [18 (link)], [5 ][OTf]2 [19 (link)–20 (link)] and 6 [21 (link)] were prepared using literature methods. Solvents were dried using an Innovative Technologies solvent purification system. Thin-layer chromatography (TLC) was performed using Teledyne Silica gel 60 F254 plates and viewed under UV light. Column chromatography was performed using Silicycle ultra-pure silica gel (230–400 mesh). The solvents were dried and distilled prior to use. NMR spectra were recorded on a Bruker Avance III console equipped with an 11.7 T magnet (e.g., 500 MHz for 1H). Samples were locked to the deuterated solvent and all chemical shifts reported in ppm referenced to tetramethylsilane. Mass spectra were recorded on a Waters Xevo G2-XS instrument. Solutions with concentrations of 0.001 molar were prepared in methanol and injected for analysis at a rate of 5 µL/min using a syringe pump.
3
Synthesis and Characterization of Organometallic Complexes
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Tetrabutylammonium tetrachlorooxorhenate(V), 4-Chloroaniline, 4-Bromoaniline, 4-Methylaniline, 4-isopropylaniline, aniline, 4-Methylcatechol, and 1,2-dihydroxybenzene were purchased from Sigma-Aldrich. Acetonitrile (HPLC grade) and triethylamine were purchased from Fisher Scientific. Nitrogen used as nebulizing and drying gas was generated by MS-NGM 11 (Bruker Daltonics, Bremen, Germany) nitrogen generator.
4
Functionalization of Carbon Nonwoven
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The prewetted carbon nonwoven (10 × 10 mm2) was placed in a round-bottom flask and treated with 25 mL of 1 M HCl, and then the mixture was heated to 80 °C. After reaching the required temperature, isoamyl nitrite (0.7 mL, 5 mmol) and 4-bromoaniline (0.86 g, 5 mmol) (Sigma-Aldrich, Poznan, Poland) were added to the mixture. The reaction was carried out at 80 °C for 18 h. Finally, the nonwoven fabric was washed with DMF (3 × 5 mL) and DCM (3 × 5 mL).
5
Metal-Organic Complexation and Biomolecular Interactions
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All reagents and
solvents used in this synthesis were commercially available. Reagent-grade
chemicals were used in this experiment. Hence, no further purification
was needed. Salicylaldehyde, 5-bromo Salicylaldehyde, 4-bromo aniline,
ctDNA, HSA, EB, and DAPI were obtained from Sigma-Aldrich Chemicals.
CuCl2, ZnCl2, and triethyl amine (Et3N) were purchased from Merck. Elemental analyses were performed using
a PerkinElmer 240C elemental analyzer. Electronic absorption spectral
data were collected by using a PerkinElmer UV–vis Lambda 365
spectrophotometer at room temperature. The concentration of ctDNA
per nucleotide was determined by absorption spectroscopy using a molar
extinction coefficient (€) 6600 (M–1 cm–1) at 260 nm. ctDNA interaction studies were performed
in a citrate-phosphate (CP) buffer of 10 mM [Na+] at pH
7.40 containing 0.5 mM Na2HPO4, and HSA interaction
studies were performed in Tris buffer.
Caution! Mercury salts are extremely toxic, so proper caution should be taken
before use.
solvents used in this synthesis were commercially available. Reagent-grade
chemicals were used in this experiment. Hence, no further purification
was needed. Salicylaldehyde, 5-bromo Salicylaldehyde, 4-bromo aniline,
ctDNA, HSA, EB, and DAPI were obtained from Sigma-Aldrich Chemicals.
CuCl2, ZnCl2, and triethyl amine (Et3N) were purchased from Merck. Elemental analyses were performed using
a PerkinElmer 240C elemental analyzer. Electronic absorption spectral
data were collected by using a PerkinElmer UV–vis Lambda 365
spectrophotometer at room temperature. The concentration of ctDNA
per nucleotide was determined by absorption spectroscopy using a molar
extinction coefficient (€) 6600 (M–1 cm–1) at 260 nm. ctDNA interaction studies were performed
in a citrate-phosphate (CP) buffer of 10 mM [Na+] at pH
7.40 containing 0.5 mM Na2HPO4, and HSA interaction
studies were performed in Tris buffer.
before use.
6
Synthesis and Characterization of Benzothiazole Derivatives
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All reagents, catalysts,
and chemicals utilized in the study were of analytical quality and
supplied by commercial providers. The chemicals used in this study
were sourced from various suppliers. 2-Aminobenzothiazole (Sigma-Aldrich,
99%), sulfapyridine (NENTECH, U.K., 99%), sulfaguanidine (Tokyo Chemical
Industry, Japan, 98%), piperazine (Central Dreug House, India, 99%),
benzylamine (Loba Chemi, India, 99%), cyclohexylamine (Sigma-Aldrich,
99%), 3,4 dimethylaniline (GCC, U.K., 98%), 4-chloroaniline (Sigma-Aldrich,
98%), 4-bromoaniline (Sigma-Aldrich, 90%), 4-fluoroaniline (Sigma-Aldrich,
99%), 4-nitroaniline (Janssen, Belgium, 98%), diethylamine (GCC, U.K.,
98%), m-toluidine (Sigma-Aldrich, 99%), morpholine
(Tokyo Chemical Industry, Japan, 99%), dimethylformamide (DMF) (Carlo
Erba, France, 99.9%), acetone (Carlo Erba, France, 99%), triethylamine
(TEA) (TEDIA, 99%), ethanol (Carlo Erba, France, 98%), n-hexane (Carlo Erba, France, 95%), sodium bicarbonate (NaHCO3) (GCC, U.K., 99.5%), sodium hydroxide (NaOH) (GCC, U.K.,
99.5%), chloroform (Carlo Erba, France, 99.9%), and dimethyl sulfoxide
(DMSO) (Carlo Erba, France, 99%) and monochloroacetyl chloride (α
Chemika, India) were used.
and chemicals utilized in the study were of analytical quality and
supplied by commercial providers. The chemicals used in this study
were sourced from various suppliers. 2-Aminobenzothiazole (Sigma-Aldrich,
99%), sulfapyridine (NENTECH, U.K., 99%), sulfaguanidine (Tokyo Chemical
Industry, Japan, 98%), piperazine (Central Dreug House, India, 99%),
benzylamine (Loba Chemi, India, 99%), cyclohexylamine (Sigma-Aldrich,
99%), 3,4 dimethylaniline (GCC, U.K., 98%), 4-chloroaniline (Sigma-Aldrich,
98%), 4-bromoaniline (Sigma-Aldrich, 90%), 4-fluoroaniline (Sigma-Aldrich,
99%), 4-nitroaniline (Janssen, Belgium, 98%), diethylamine (GCC, U.K.,
98%), m-toluidine (Sigma-Aldrich, 99%), morpholine
(Tokyo Chemical Industry, Japan, 99%), dimethylformamide (DMF) (Carlo
Erba, France, 99.9%), acetone (Carlo Erba, France, 99%), triethylamine
(TEA) (TEDIA, 99%), ethanol (Carlo Erba, France, 98%), n-hexane (Carlo Erba, France, 95%), sodium bicarbonate (NaHCO3) (GCC, U.K., 99.5%), sodium hydroxide (NaOH) (GCC, U.K.,
99.5%), chloroform (Carlo Erba, France, 99.9%), and dimethyl sulfoxide
(DMSO) (Carlo Erba, France, 99%) and monochloroacetyl chloride (α
Chemika, India) were used.
7
Synthesis and Characterization of Copper Complexes
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For the synthesis and characterization the following commercial chemicals were used: 4-Bromoaniline (CAS: 106-40-1, 97%, Sigma Aldrich), Cu(NO3)2·3H2O (CAS: 10031-43-3, 98%, Sigma Aldrich), N,N-Dimethylethylenediamine (CAS: 108-00-9, 95%, Sigma Aldrich), 9H-Carbazole (CAS: 86-74-8, >95%, Sigma Aldrich), Copper(I) iodine (CAS: 7681-65-4 99%, Riedel-de Haen), N,N′-Dimethylformamid, (CAS: 68-12-2, 99%, Fischer Scientific). Solvents and stock chemicals were used with purities exceeding 98%.
8
Synthesis of Substituted Anilines
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4-Bromoaniline (97%) and 3-bromoaniline (97%)
were purchased from Sigma-Aldrich. Ferrous sulfate (FeSO4·7H2O) and potassium permanganate (KMnO4) were purchased from Central Drug House (CDH) and used as received.
The solvents dimethylformamide (DMF) [high-performance liquid chromatography
(HPLC) grade] and TEA were purchased from CDH. TEA was dried in our
laboratory. PA was purchased from Thomas Baker (Chemicals). Tetrakis(triphenylphosphine)palladium(0)
(Pd(PPh3)4) (99%) and copper iodide (CuI) were
purchased from Sigma-Aldrich and were used as received.
were purchased from Sigma-Aldrich. Ferrous sulfate (FeSO4·7H2O) and potassium permanganate (KMnO4) were purchased from Central Drug House (CDH) and used as received.
The solvents dimethylformamide (DMF) [high-performance liquid chromatography
(HPLC) grade] and TEA were purchased from CDH. TEA was dried in our
laboratory. PA was purchased from Thomas Baker (Chemicals). Tetrakis(triphenylphosphine)palladium(0)
(Pd(PPh3)4) (99%) and copper iodide (CuI) were
purchased from Sigma-Aldrich and were used as received.
9
Synthesis and Characterization of Sulfanilamide Derivatives
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All of the reagents and
chemicals were of analytical grade and purchased from commercial suppliers.
Sulfapyridine (NENTECH, U.K., 99%), sulfaguanidine (Tokyo Chemical
Industry, Japan, 98%), cyanuric chloride (Acros Organics, China, 99%),
aniline (GCC, U.K., 99.5%), benzylamine (LobaChemi, India, 99%), cyclopropylamine
(Sigma-Aldrich, 98%), cyclohexyl amine (Sigma-Aldrich, 99%), diethylamine
(GCC, U.K., 98%), m-toluidine (Sigma-Aldrich, 99%),
3,4-dimethylaniline (GCC, U.K., 98%), 4-chloroaniline (Sigma-Aldrich,
98%), 4-bromoaniline (Sigma-Aldrich, 90%), 4-fluoroaniline (Sigma-Aldrich,
99%), 4-nitroaniline (Janssen, Belgium, 98%), morpholine (Tokyo Chemical
Industry, Japan, 99%), acetone (Carlo Erba, France, 99%), ethanol
(Carlo Erba, France, 98%), dimethylformamide (DMF) (Carlo Erba, France,
99.9%), n-hexane (Carlo Erba, France, 95%), sodium
bicarbonate (NaHCO3) (GCC, U.K., 99.5%), sodium hydroxide
(NaOH) (GCC, U.K., 99.5%), triethylamine (TEA) (TEDIA, 99%), chloroform
(Carlo Erba, France, 99.9%) and dimethyl sulfoxide (DMSO) (Carlo Erba,
France, 99%).
chemicals were of analytical grade and purchased from commercial suppliers.
Sulfapyridine (NENTECH, U.K., 99%), sulfaguanidine (Tokyo Chemical
Industry, Japan, 98%), cyanuric chloride (Acros Organics, China, 99%),
aniline (GCC, U.K., 99.5%), benzylamine (LobaChemi, India, 99%), cyclopropylamine
(Sigma-Aldrich, 98%), cyclohexyl amine (Sigma-Aldrich, 99%), diethylamine
(GCC, U.K., 98%), m-toluidine (Sigma-Aldrich, 99%),
3,4-dimethylaniline (GCC, U.K., 98%), 4-chloroaniline (Sigma-Aldrich,
98%), 4-bromoaniline (Sigma-Aldrich, 90%), 4-fluoroaniline (Sigma-Aldrich,
99%), 4-nitroaniline (Janssen, Belgium, 98%), morpholine (Tokyo Chemical
Industry, Japan, 99%), acetone (Carlo Erba, France, 99%), ethanol
(Carlo Erba, France, 98%), dimethylformamide (DMF) (Carlo Erba, France,
99.9%), n-hexane (Carlo Erba, France, 95%), sodium
bicarbonate (NaHCO3) (GCC, U.K., 99.5%), sodium hydroxide
(NaOH) (GCC, U.K., 99.5%), triethylamine (TEA) (TEDIA, 99%), chloroform
(Carlo Erba, France, 99.9%) and dimethyl sulfoxide (DMSO) (Carlo Erba,
France, 99%).
10
Synthesis and Characterization of Metal Complexes
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1,10‐phenanthroline (Sigma Aldrich, 97 %), 2–2’‐bipyridine (Alfa Aesar, 99 %), 4,7‐dimethyl‐1,10‐phenanthroline (Sigma Aldrich), 1,10‐phenanthroline‐5‐amine (Sigma Aldrich, 97 %), 4‐bromoaniline (Sigma Aldrich, 99 %), NaNO2 (Merck, 99.9 %), K3Fe(CN)6 (Sigma Aldrich, 99.98 %) and Cu(OTf)2 (Alfa Aesar, ≥99 %) were used as received. Electrolyte solutions were prepared with HClO4 (Merck suprapur, 70 %), HCl (Merck, 37 %), Na2HPO4 (Merck, 99.9 %), NaH2PO4 (Merck, 99.9 %), NaCl (Merck, 99.9 %) and were prepared with MilliQ water (>18.2 MΩ cm resistivity). Argon and oxygen (5.0) were purchased from Linde Gas.
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