Imp 1088

Manufactured by Cayman Chemical

Sourced in United States

IMP-1088 is a laboratory instrument used for the detection and quantification of analytes in various samples. It utilizes a specific analytical technique to provide accurate and reliable results. The core function of IMP-1088 is to facilitate the analysis of target compounds in a controlled and standardized environment.

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Lab products found in correlation

Mem vitamin, by Thermo Fisher Scientific (1 mentions) On targetplus smartpool, by Horizon Discovery (1 mentions) Doxycycline dox, by Merck Group (1 mentions) Mcc950, by Merck Group (1 mentions) Erastin, by Merck Group (1 mentions) Ml210, by Cayman Chemical (1 mentions) Ifsp1, by ChemDiv (1 mentions) Fino2, by Cayman Chemical (1 mentions) Lip 1, by Selleck Chemicals (1 mentions) Deferoxamine mesylate salt dfo, by Merck Group (1 mentions) Nec 1, by Enzo Life Sciences (1 mentions) Lipopolysaccharides (lps), by Merck Group (1 mentions) Nigericin, by Thermo Fisher Scientific (1 mentions) Staurosporine, by Cayman Chemical (1 mentions) Fin56, by Cayman Chemical (1 mentions) Olaparib, by Selleck Chemicals (1 mentions)

4 protocols using imp 1088

Cell growth assay with 2-hydroxymyristate and IMP-1088

Cited 1 time

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Cells were grown in high-glucose DMEM supplemented with 10% fetal bovine serum, 2 mM glutamine, 5 mM non-essential amino acids and 1% (v/v) MEM vitamins (Thermo Fisher Scientific). Growth measurements were performed in 96-well plates and quantified by staining with the sulforhodamine B (SRB) dye, as previously described [3 (link)]. Absorbance was measured at 560 nm with a microplate reader. As indicated in the legend of figures, cells were grown in the presence of increasing concentrations of 2-hydroxymyristate (Cayman, Ann Arbor, MI, USA) and IMP-1088 (Cayman).

Soupene E, & Kuypers F.A. (2022). Dual Role of ACBD6 in the Acylation Remodeling of Lipids and Proteins. Biomolecules, 12(12), 1726.

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Myristoylation Detection and Inhibition

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Myristoylation was detected using a myristoylated protein assay kit (abcam, USA) following the manufacturer’s instructions. Cells without myristic acid labeling served as background controls. To test the myristoylation inhibitor, cells were pre-incubated with 1 µM n-myristoyltransferase inhibitor IMP-1088 (Cayman Chemical, USA) for 1h before stimulation with 100 ng/ml upLPS overnight.

Maeder C., Speer T., Wirth A., Boeckel J.N., Fatima S., Shahzad K., Freichel M., Laufs U, & Gaul S. (2023). Membrane-bound Interleukin-1α mediates leukocyte adhesion during atherogenesis. Frontiers in Immunology, 14, 1252384.

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Iodixanol Density Gradient Cell Fractionation

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IMP-1088 was purchased from Cayman Chemical (Cat# 25366–1). Iodixanol (Opti-Prep Density Gradient Medium) was purchased from Millipore-Sigma (Cat# D1556). SMARTPool ON-TARGETplus and non-targeting control #2 siRNAs were purchased from Dharmacon.

Shirasaki T., Feng H., Duyvesteyn H.M., Fusco W.G., McKnight K.L., Xie L., Boyce M., Kumar S., Barouch-Bentov R., González-López O., McNamara R., Wang L., Hertel-Wulff A., Chen X., Einav S., Duncan J.A., Kapustina M., Fry E.E., Stuart D.I, & Lemon S.M. (2022). Nonlytic cellular release of hepatitis A virus requires dual capsid recruitment of the ESCRT-associated Bro1 domain proteins HD-PTP and ALIX. PLoS Pathogens, 18(8), e1010543.

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Ferroptosis Regulators Protocol

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Lip-1 (Selleckchem, cat. no. S7699), doxycycline (Dox; Sigma, cat. no. D9891), RSL3 (Cayman, cat. no. 19288), BSO (Sigma, cat. no. B2515), iFSP1 (ChemDiv, cat. no. 8009-2626), icFSP1 (ChemDiv, cat. no. L892-0224 or custom synthesis by Intonation Research Laboratories), erastin (Merck, cat. no. 329600), ML210 (Cayman, cat. no. Cay23282-1), FIN56 (Cayman, cat. no. Cay25180-5), FINO2 (Cayman, cat. no. Cay25096-1), deferoxamine mesylate salt (DFO; Sigma, cat. no. 138-14-7), ferrostatin-1 (Fer-1; Sigma, cat. no. SML0583), zVAD-FMK (zVAD; Enzo Life Sciences, cat. no. ALX-260-02), necrostatin-1s (Nec-1s; Enzo Life Sciences, cat. no. BV-2263-5), MCC950 (Sigma, cat. no. 5381200001), olaparib (Selleckchem, cat. no. S1060), staurosporine (STS; Cayman, cat. no. 81590), recombinant human tumour necrosis factor (TNF; R&D Systems, cat. no. NBP2-35076), Smac mimic (BV-6; Selleckchem, cat. no. S7597), nigericin (Thermo Fisher, cat. no. N1495), IMP-1088 (Cayman, cat. no. Cay25366-1) and lipopolysaccharide (LPS; Sigma, cat. no. L2880) were used in this study.

Nakamura T., Hipp C., Santos Dias Mourão A., Borggräfe J., Aldrovandi M., Henkelmann B., Wanninger J., Mishima E., Lytton E., Emler D., Proneth B., Sattler M, & Conrad M. (2023). Phase separation of FSP1 promotes ferroptosis. Nature, 619(7969), 371-377.

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