Fluralaner

Manufactured by Cayman Chemical

Fluralaner is a chemical compound produced by Cayman Chemical. It is a white to off-white crystalline solid. Fluralaner is a selective inhibitor of γ-aminobutyric acid (GABA) and glutamate-gated chloride channels.

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Lab products found in correlation

Optima lc ms grade methanol, by Thermo Fisher Scientific (1 mentions) Millipore synergy uv water purification system, by Merck Group (1 mentions) Ivermectin, by Merck Group (1 mentions)

2 protocols using fluralaner

Quantification of Fluralaner by LC-MS/MS

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Fluralaner was purchased from Cayman chemical (Ann Arbor, MI). Acetonitrile Optima LC-MS grade (ACN), Methanol Optima LC-MS grade (MeOH), Formic acid Optima LC-MS grade, and o-phosphoric acid (85wt%) HPLC grade, were purchased from Fisher Scientific (Thermo Fisher, Waltham, MA). Ultrapure (type 1) water was obtained from a Millipore Synergy UV water purification system (Millipore Sigma, Burlington, MA) in the lab. Physicochemical properties of Fluralaner are shown in Table 1.Table 1

Physicochemical properties and structure of Fluralaner.

Table 1

Molecular formula	C₂₂H₁₇C_l2F₆N₃O₃
Molecular weight	556.3 g/mol
Log P	5.4
Water solubility	0.1 mg/L

Elliot B.A., Enomoto H., Petritz O., Crespo R., Yeatts J., Fricke I., Singleton A., Thomson A, & Baynes R.E. (2023). Pharmacokinetics of intravenously and trans-dermally administered fluralaner in healthy laying shaver hens: fluralaner in chickens. Poultry Science, 103(3), 103362.

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Compound Efficacy on Mite Viability

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Mites were collected as described above, and freshly fed adult females were sorted. Mites were immobilised on an adhesive tape, and a volume of 13.8 nL of tested compound (≤1% v/v DMSO) was microinjected into the mite’s haemocoel (Drummond, USA). After 10 min, injected mites were collected into 1.5 mL microcentrifuge tubes (5 individuals in 5 eppi tubes or 8 individuals in 3 eppi tubes for each concentration) and stored in the incubator set at 21 °C. The viability and vitality of the mites were monitored every 24 h for 7 days. Compounds used in the study: Fipronil (Sigma-Aldrich Supelco, catalogue number 16785), Fluralaner (Cayman Chemical, item number 22061), Ivermectin (Sigma-Aldrich, catalogue number I8898).

Ribeiro J.M., Hartmann D., Bartošová-Sojková P., Debat H., Moos M., Šimek P., Fara J., Palus M., Kučera M., Hajdušek O., Sojka D., Kopáček P, & Perner J. (2023). Blood-feeding adaptations and virome assessment of the poultry red mite Dermanyssus gallinae guided by RNA-seq. Communications Biology, 6, 517.

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