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Multihance

Manufactured by Bayer
Sourced in Germany, Italy

MultiHance is a contrast agent used in magnetic resonance imaging (MRI) procedures. It contains the active ingredient gadobenate dimeglumine, which helps enhance the visibility of internal structures during MRI scans.

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2 protocols using multihance

1

4D-flow MRI of Thoracic Aorta

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All subjects underwent 4D-flow MRI with full volumetric coverage of the thoracic aorta (sagittal-oblique 3D volume) using either 1.5T (N = 1053; Aera, Avanto, or Espree; Siemens Healthineers, Erlangen, Germany) or 3T MRI systems (N = 140; Skyra; Siemens Healthineers). The 4D-flow MRI pulse sequence parameters were as follows: spatial resolution = 1.2–3.1 × 1.2–3.1 × 1.2–5.0 mm3, temporal resolution = 32.8–44.8 ms, velocity sensitivity (venc) = 80–500 cm/s, FOV = 124–406 × 180–500 × 38–176 mm3, TE = 2.1–3.0 ms, TR = 4.1–5.7 ms, and flip angle = 7°−25°. Data for all subjects were acquired during free-breathing with respiratory navigator gating and either prospective (N = 1172) or retrospective (N = 21) electrocardiographic gating. For N = 1064 subjects, a contrast agent (either Gadavist, Magavist, Multihance, dotarem, or Ablavar [Bayer Healthcare, Berlin, Germany] or Feraheme [Amag Pharmaceuticals, Waltham, MA]) was administered before the 4D-flow scan acquisition as standard-of-care protocol.
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2

Comparative Evaluation of Gadolinium Contrast Agents

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Five commercially available GBCAs were tested: a linear and nonionic GBCA, gadodiamide (Gd-DTPA-BMA, Omniscan; GE Healthcare, Chalfont St Giles, United Kingdom); 2 linear and ionic GBCAs, gadopentetic acid (Gd-DTPA; Magnevist, Bayer Healthcare, Berlin, Germany) and gadobenic acid (gadolinium-benzyloxypropionic diethylenetriamine tetraacetic acid [Gd-BOPTA], MultiHance, Bracco, Milan, Italy); a macrocyclic and nonionic GBCA, gadobutrol (gadolinium-butrol- 1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid, Gadovist; Bayer Healthcare, Berlin, Germany); and a macrocyclic and ionic GBCA, gadoteric acid (gadolinium-,4,7,10-tetraazacyclododecane-N,N′,N′,N′′-tetraacetic acid, Dotarem; Guerbet, Villepinte, France).
The commercial solution of gadodiamide contains 5% calcium-diethylene triamine pentaacetic acid bismethylamide (Ca-DTPA-BMA) (caldiamide), and the pharmaceutical solution of gadopentetic acid contains 0.2% free diethylene triamine pentaacetic acid (DTPA) ligand. Gadolinium acetate (“free” soluble Gd3+) as well as the Ca-DTPA-BMA and DTPA ligands were also tested.
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