Relafl fl

Manufactured by Jackson ImmunoResearch

RelAfl/fl is a laboratory reagent used in molecular biology research. It is a genetically engineered strain of mice that carries a floxed (flanked by loxP sites) allele of the RelA gene, which is a key component of the NF-κB transcription factor complex. This reagent allows for the conditional knockout or modulation of the RelA gene in specific cell types or tissues, enabling researchers to study the role of NF-κB signaling in various biological processes.

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Relafl/fl mice (2 citations)

2 protocols using relafl fl

Mouse Immunization Model Protocols

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Age- and gender-matched male, female mice (2 – 3 months old) were used for immunization. C57BL/6J, B6.CD45.1(#002014), Bcl6^fl/fl (#023727), CCR2^−/− (#004999), RelA^fl/fl (#024342), IL-21-VFP(#030295), CD11c^cre (#008068) and LysM^cre (#004781) mice were purchased from The Jackson Laboratory. Mice were housed and bred under pathogen-free conditions in the Animal Research Facility at the University of Florida. Cre-negative littermates were used as controls for experiments. All mouse experiments were performed by the regulations and approval of the Institutional Animal Care and Use Committee at the University of Florida, IACUC number 201909362.

Mansouri S., Katikaneni D.S., Gogoi H, & Jin L. (2021). moDCs differentiate into Bcl6+ mature moDCs to promote cyclic di-GMP vaccine adjuvant-induced memory TH cells in the lung. Journal of immunology (Baltimore, Md. : 1950), 206(9), 2233-2245.

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Murine Models for Cancer Research

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Wild-type C57BL/6J mice and breeding pairs of Apc^Min^/+, Gfap-tk (thymidine kinase), Gfap-Cre, Plp1-CreER^T, inducible diphtheria toxin receptor (iDTR), Rag2^-/- γc^-/-, Myd88^fl/fl, Ifngr1^fl/fl, Rela^fl/fl, and Stat3^fl/fl mice were purchased from The Jackson Laboratory. All mice were housed in an American Association for the Accreditation of Laboratory Animal Care-accredited animal facility and maintained in specific pathogen-free conditions on wood-chip bedding and fed standard rodent chow ad libitum unless otherwise stated. Littermates were used for controls whenever possible; if different litters had to be combined, mice were age matched and non-littermates were co-housed to eliminate effects of the microbiome. Mice of both sexes were utilized in the experiments performed in this study, and experiments were carried out during the light cycle. All animal care and experimentation were approved by the Stanford University Institutional Animal Care and Use Committee.

Yuan R., Bhattacharya N., Kenkel J.A., Shen J., DiMaio M.A., Bagchi S., Prestwood T.R., Habtezion A, & Engleman E.G. (2020). Enteric Glia Play a Critical Role in Promoting the Development of Colorectal Cancer. Frontiers in Oncology, 10, 595892.

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