Human1m duo array

Manufactured by Illumina

Sourced in United States

The Illumina Human1M-Duo array is a high-density genotyping platform designed to interrogate over 1 million genetic markers across the human genome. The array provides comprehensive coverage of common and rare genetic variations, enabling researchers to conduct large-scale genetic association studies.

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Lab products found in correlation

Humanomniexpress 12 beadchip, by Illumina (1 mentions) Genomestudio v2011, by Illumina (1 mentions) Humanomni1 quad beadchip, by Illumina (1 mentions)

Close spelling variants of this product

Human1M-Duo BeadChip array Human1M-Duo Human1M array Human1M

2 protocols using human1m duo array

Genome-Wide Genotyping and Imputation

Cited 2 times

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Genomic DNA was extracted from the peripheral blood collected at week 0 (Macherey-Nagel kit, NucleoSpin Blood XL, Düren, Germany; or with standard method).
Two hundred and eighty-two PHSS patients were genotyped using the Illumina Human1M-Duo array (Illumina Inc, San Diego, California, USA) within HYPERGENES project [19 (link)] and 119 using the Illumina HumanOmniExpress array within InterOmics project (http://www.interomics.eu/).
Two hundred and fifteen HCTZ-Milan samples were genotyped using the Illumina Human1M-Duo array within HYPERGENES project [19 (link)].
The imputation was performed using Minimac [20 (link)] and 1000 Genomes haplotypes as reference (release March 2012). Imputed single-nucleotide polymorphisms (SNPs) with low imputation quality (Rsq < 0.8) were not used in the association analysis. Genotyping and imputation details are in Methods S5 (Supplemental Digital Content, http://links.lww.com/HJH/A467).

Chittani M., Zaninello R., Lanzani C., Frau F., Ortu M.F., Salvi E., Fresu G., Citterio L., Braga D., Piras D.A., Carpini S.D., Velayutham D., Simonini M., Argiolas G., Pozzoli S., Troffa C., Glorioso V., Kontula K.K., Hiltunen T.P., Donner K.M., Turner S.T., Boerwinkle E., Chapman A.B., Padmanabhan S., Dominiczak A.F., Melander O., Johnson J.A., Cooper-Dehoff R.M., Gong Y., Rivera N.V., Condorelli G., Trimarco B., Manunta P., Cusi D., Glorioso N, & Barlassina C. (2015). TET2 and CSMD1genes affect SBP response to hydrochlorothiazide in never-treated essential hypertensives. Journal of hypertension, 33(6), 1301-1309.

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Genotyping and Quality Control of GENRES, PEAR, GERA Samples

Cited 2 times

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The DNA samples of 228 GENRES study subjects were successfully genotyped (success rates >99%) at the Institute for Molecular Medicine Technology Centre, University of Helsinki using the Illumina HumanOmniExpress‐12 BeadChip (Illumina, Inc, San Diego, CA). The genotypes (NCBI build 37, hg19) were called and quality controlled using GenomeStudio v. 2011.1 software (Illumina, Inc) and in‐house‐developed database tools. Further quality steps, including identity‐by‐state clustering and gender check, were performed using Plink software and PLINK v1.07 toolset.^{20 (link)} Of the total of 709 357 genotyped autosomal SNPs, 707 658 passed these quality‐control steps. After this, SNPs with Hardy‐Weinberg equilibrium P value <1×10⁻⁵ (393 SNPs) and minor allele frequency <0.01 (75 421 SNPs) were excluded, which resulted in 631 844 autosomal SNPs that were used for analysis.
DNA samples from PEAR were genotyped using Illumina Human Omni1‐Quad BeadChip (Illumina) as previously described.^{11 (link)} DNA samples from GERA I and II study participants were genotyped using the Affymetrix GeneChip Human Mapping 6.0 Array Sets.^{10 (link)–11 (link)} SOPHIA samples were genotyped using the Illumina Human1M‐Duo array (Illumina) and imputed using MACH software and the HapMap CEU haplotypes (release 22) as reference.

Hiltunen T.P., Donner K.M., Sarin A., Saarela J., Ripatti S., Chapman A.B., Gums J.G., Gong Y., Cooper‐DeHoff R.M., Frau F., Glorioso V., Zaninello R., Salvi E., Glorioso N., Boerwinkle E., Turner S.T., Johnson J.A, & Kontula K.K. (2015). Pharmacogenomics of Hypertension: A Genome‐Wide, Placebo‐Controlled Cross‐Over Study, Using Four Classes of Antihypertensive Drugs. Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 4(1), e001521.

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