α bromoisobutyryl bromide bibb

Acetonitrile (ACN, VWR), 3-aminopropyldimethylethoxysilane (APDMES) (abcr, 97%), $\alpha$ -bromoisobutyryl bromide (BIBB) (Sigma Aldrich, 98%), CuBr₂ (Sigma-Aldrich, >99.9%), CuBr (Sigma-Aldrich, >99.9%), dichlormethane (DCM) (VWR), 4-(dimethylamino)-pyridin (DMAP) (Sigma Aldrich), ethanol (Sigma Aldrich), hydrogen peroxide (Carl Roth, 30%), N,N,N′,N′′,N′′′-pentamethyldiethylenetriamine (PMDETA) (Sigma Aldrich, 99%), styrene (Sigma Aldrich, 99%), methyl methacrylate (MMA) (Sigma Aldrich, 99%), water, methanol (Sigma Aldrich), sodium ascorbate (Sigma Aldrich), sulfuric acid (Fischer chemicals, 95%), triethylamine (TEA) (Sigma Aldrich, 99%), inhibitor remover resin (Alfa Aesar), aluminum oxide active basic (Sigma Aldrich). All compounds were used without further purification. To remove the inhibitor hydroquinone monomethyl ether (MEHQ) from MMA and 4-tert-butylcatechol from styrene, MMA was stirred with inhibitor remover resin for 30 min and styrene was passed through a basic aluminum oxide packed column. Silicon substrates were purchased from Active Business Company GmbH Brunnthal Germany.

N-Isopropylacrylamide (NIPAAm, 99%, Acros) was purified by recrystallization in n-hexane for three times prior to use. The monosaccharide monomer (Glc), tetra-acetylated monosaccharide monomer (AcGlc), trifluoromethyl phenylthiourea monomer (PT), and various tripeptides were synthesized (see Supplementary information for details). Toluene, dichloromethane, methanol, and pyridine were distilled and dried before use according to standard procedures. Cu(I)Br (99.998%, Alfa Aesar), 3-aminopropyl-trimethoxysilane (ATMS, 97%, Sigma-Aldrich), α-bromoisobutyryl bromide (BiBB, 98%, Sigma-Aldrich), N,N,N′,N′,N′-pentamethyldiethylenetriamine (PMDETA, 99%, Sigma-Aldrich) were used as received. Double distilled water (18.2 MΩ∙cm, MilliQ system) was used, and other general solvents and chemicals were used as received.