MSZ (Erregiere),
microcrystalline cellulose (JRS Pharma), partially pregelatinized maize starch (Colorcon), povidone (BASF), magnesium stearate (Mosselman), lactose monohydrate (Meggle), croscarmellose sodium (FMC BioPolymer),
colloidal silicon dioxide (Evonik), talc (Luzenac), calcium carbonate (Shangai Nuoceng Pharmaceuticals). All the components were of pharmaceutical grade and complied with the relevant monographs of the European Pharmacopoeia, 9th edition [10]. Coating system:
Opadry clear (Colorcon), Triethylcitrate (Colorcon),
Acryl-Eze (Colorcon). Also purified water (Ph. Eur., 2016) was used in the process.
Process steps and equipment -laboratory batches weighing -balance (Mettler Toledo), wet granulation -
fluid bed granulator (Bosch), manual blending, tableting -eccentric press (Riva).
Process steps and equipment -pilot batches weighing -balances and scales (Mettler Toledo), wet granulation -
fluid bed granulator (Bosch), blendingblender (Servolift), tableting -rotary tableting press (Fette 102i), oblong punch 18.2/7.7 mm, coatingcoating equipment (O'Hara Technologies).
Chiş A.A., Crăciun I., Dobrea C.M., Gligor F.G., Bărbat A., & Rus L.L. (2020). Preformulation and preliminary formulation studies of mesalazine gastro-resistant tablets. Romanian Journal of Pharmaceutical Practice, 13(4), 207-213.