1 4 dioxane

Manufactured by Merck Group

Sourced in United States, Germany, United Kingdom, Greece, Poland, Spain, Canada, Italy, China

1,4-dioxane is a colorless organic compound with the chemical formula (CH2)2O2. It is commonly used as a solvent and chemical intermediate in the production of various industrial and laboratory products.

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Lab products found in correlation

Ethanol, by Merck Group (18 mentions) Tetrahydrofuran, by Merck Group (16 mentions) Methanol, by Merck Group (16 mentions) N n dimethylformamide (dmf), by Merck Group (13 mentions) Dimethyl sulfoxide (dmso), by Merck Group (13 mentions) Acetonitrile, by Merck Group (11 mentions) Acetone, by Merck Group (11 mentions) Ethyl acetate, by Merck Group (11 mentions) Chloroform, by Merck Group (11 mentions) Acetic acid, by Merck Group (9 mentions) N hexane, by Merck Group (8 mentions) Toluene, by Merck Group (8 mentions) Pyridine, by Merck Group (8 mentions) Triethylamine, by Merck Group (7 mentions) Diethyl ether, by Merck Group (7 mentions) Hydrochloric acid (hcl), by Merck Group (7 mentions) Azobisisobutyronitrile, by Merck Group (6 mentions) Ethylene glycol, by Merck Group (6 mentions) Sodium hydroxide (naoh), by Merck Group (6 mentions) Mesitylene, by Merck Group (5 mentions)

Close spelling variants of this product

Dioxane (79 citations) Anhydrous 1,4-dioxane (8 citations) 3,6-dimethyl-1,4-dioxane-2,5-dione (D,L-lactide), (5 citations) (3S)-cis-3,6-Dimethyl-1,4-dioxane-2,5-dione (4 citations) 1.4-dioxane (HPLC-grade) (3 citations) 1,4-dioxane HPLC grade (2 citations) 3,6-dimethyl-1,4-dioxane-2,5-dione (2 citations)

171 protocols using 1 4 dioxane

Fabrication of Porous PLGA-HA-MSM Scaffolds

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A modified frozen and vacuum drying method was used to fabricate the porous scaffolds as reported in our previous study.38 (link)
d,l-Lactide (LA) and glycolide (GA) monomer were obtained from Purac (Netherlands). Poly (lactide-co-glycolide) (PLGA, LA:GA= 80:20, Mw = 80,000 g·mol⁻¹) was synthesized as previously reported.39 (link) Briefly, with the assistance of magnetic stirring and ultrasonic processing, HA (Emperor Nano Material Co., Ltd, Nanjing, China) was uniformly suspended in dehydrated 1,4-dioxane (Sigma-Aldrich, USA), and added to a solution of PLGA/1,4-dioxane (10%, w/v). MSM (Jilin Herun Chemical Co., Ltd, China) was dissolved in acetone (Sigma-Aldrich, USA) and then added into HA/PLGA/1,4-dioxane solution to obtain the MSM/HA/PLGA solution. The volume ratio of acetone and 1.4-dioxane in all the groups was consistent, and the doping levels of MSM in the obtained composites were 0.01%, 0.1%, 1%, and 10%, respectively. The content of HA in all the composites was 10%. The solutions were gently stirred to obtain a homogenous suspension. Then, the obtained composite solutions were frozen within the polypropylene (PP) tubes at 4℃ for 24 hours without any protection and then vacuum dried at −4℃ to thoroughly remove 1.4-dioxane. HA/PLGA scaffolds without adding MSM were prepared using the same method as control. The samples were kept in a vacuum drying oven.

Guo Y., Li P., Wang Z., Zhang P, & Wu X. (2022). Sustained Delivery of Methylsulfonylmethane from Biodegradable Scaffolds Enhances Efficient Bone Regeneration. International Journal of Nanomedicine, 17, 4829-4842.

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Synthesis of DMAEMA-OEGMA Copolymers

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The monomers 2-(dimethylamino)ethyl methacrylate (DMAEMA, 98%) and (oligo ethylene glycol)methacrylate (OEGMA) (average Mn = 950 g∙mol⁻¹, 19 ethylene oxide units) were purchased from Sigma Aldrich, Greece. Both DMAEMA and OEGMA were purified using a column filled with inhibitor removers before polymerization. 2,2′-Azobis (isobutyronitrile) (AIBN), the radical initiator utilized, was purified by recrystallization from methanol. 4-Cyano-4-(dodecylsulfanylthiocarbonyl)pentanoic acid (CDP) as the CTA, methyl iodide (CH₃I) 1-iodohexane (C₆H₁₃I, ≥98%), 1-iodododecane (C₁₂H₂₅I, 98%), 1,4-dioxane (≥99.8% pure), and tetrahydrofuran (THF, ≥99.9% pure) were obtained from Sigma Aldrich, Greece and used as received, except 1-4-dioxane, which was first dried over molecular sieves. Deuterated chloroform (CDCl₃) was used as the solvent for the ¹H-NMR experiments and was also obtained from Sigma Aldrich, Greece. Dialysis tubing membranes (MEMBRA-CEL^®) from regenerated cellulose of MWCO 3500 and a diameter of 22 mm were purchased from SERVA, Heidelberg, Germany.

Vardaxi A, & Pispas S. (2023). Stimuli-Responsive Self-Assembly of Poly(2-(Dimethylamino)ethyl Methacrylate-co-(oligo ethylene glycol)methacrylate) Random Copolymers and Their Modified Derivatives. Polymers, 15(6), 1519.

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TCDD Dosing in Pregnant Mice

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TCDD (Cambride Isotopes, Andover, MA) was diluted in 1,4-dioxane (Sigma-Aldrich, St. Louis, MO) to a working stock concentration of 0.2 mg/mL. Appropriate volume of TCDD in 1,4-dioxane was subsequently transferred to a sterile 15 ml conical tube and the liquid was evaporated in a chemical fume hood. The TCDD residue was then suspended in olive oil (Filippo Berio, Hackensack, NJ) to a concentration of 0.3μg/ml and was mixed by rotation at room temperature. Control olive oil was added to a tube with an equal volume of evaporated 1,4-dioxane. Mice were exposed to either 3μg TCDD/Kg body weight by oral gavage on gestational days 0.5 and 7.5, or olive oil vehicle control (0.1ml per 10g). Doses were given 7 days apart to insure a relatively constant level of TCDD throughout because the half life of TCDD in a C57Bl/6 mouse is approximately one week (Miniero et al., 2001 (link); Weber and Birnbaum, 1985 (link)).

Ahrenhoerster L.S., Tate E.R., Lakatos P.A., Wang X, & Laiosa M.D. (2014). Developmental Exposure to 2,3,7,8 Tetrachlorodibenzo-p-dioxin Attenuates Capacity of Hematopoietic Stem Cells to Undergo Lymphocyte Differentiation. Toxicology and applied pharmacology, 277(2), 172-182.

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Synthesis of Thiophene Derivatives

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Manipulations of air and/or moisture sensitive materials were carried out under inert atmosphere using dual vacuum/argon lines. Elemental sulfur in powder (S, Ph. Eur., BP), 2,5-dibromothiophene (95%), 4,4,5,5-tetramethyl-2-(prop-1-en-2-yl)-1,3,2-dioxaborolane (isopropenylboronic acid pinacol ester, 95%), Cs₂CO₃ (99%), NaHCO₃ (≥99.7%), KHCO₃ (≥99.7%), NaOH (≥98%), KOH (85–100.5%), Pd(PPh₃)₄ (99%), 1,4-dioxane (≥99.5%), tetra-n-butylammonium iodide (≥99%), n-nonylphenol (technical grade, mixture of regioisomers), deuterated chloroform (CDCl₃, 99.8% deut.) as well as other chemicals and solvents, were purchased from Merck-Sigma-Aldrich (Italy) and used as received.

Tavella C., Luciano G., Lova P., Patrini M., D'Arrigo C., Comoretto D, & Stagnaro P. (2022). 2,5-Diisopropenylthiophene by Suzuki–Miyaura cross-coupling reaction and its exploitation in inverse vulcanization: a case study. RSC Advances, 12(15), 8924-8935.

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Synthesis of Ethylene Brassylate Polymers

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Ethylene brassylate (EB, 1,4-dioxacycloheptadecane-5,17-dione, C₁₅H₂₆O₄, Mw = 270.36 g/mol, purity of 95.0%), squaric acid (SA, 3,4-dihydroxy-3-cyclobutene-1,2-dione, H₂C₄O₄, Mw = 114.06 g/mol, purity > 99.0%) and 1,4-Dioxane (purity ≥ 99.0%) were purchased from Sigma-Aldrich (Darmstadt, Germany). Poly(vinyl alcohol) (PVA, with different molecular weights, 72,000 and 145,000 g/mol) was acquired from Merck (Hohenbrunn, Germany), and anhydrous 1-hexanol was from Across-Organics (Geel, Belgium). All chemicals were used as received without further purification.

Crețu B.E., Nita L.E., Șerban A.M., Rusu A.G., Doroftei F, & Chiriac A.P. (2022). New Cryogels Based on Poly(vinyl alcohol) and a Copolymacrolactone System: I-Synthesis and Characterization. Nanomaterials, 12(14), 2420.

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Immobilized TRAIL Binding Assay

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6× His-TRAIL was obtained from UBPBio. Mouse Anti-Human TRAIL-UNLB and mouse Anti-Human TRAIL-BIOT (Dallas, TX, USA) were purchased from SouthernBiotech (Birmingham, AL, USA) for ELISA. Dulbecco’s Modified Eagle Medium (DMEM), penicillin–streptomycin, fetal bovine serum (FBS), trypsin, and phosphate-buffered saline (PBS) were purchased from Corning (Corning, NY, USA). Heparin and Bacteroides Heparinase II were received from Selleckchem (Radnor, PA, USA) and New England Biolabs (Beverly, MA, USA), respectively. EZ-Cytox was purchased from DoGenBio (Seoul, Korea). Fmoc-Asp and Fmoc-Arg were obtained from BOC Science (Shirley, NY, US). Monomethoxy polyethylene glycol 750, 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC), N-hydroxy succinimide (NHS), tetrabutylammonium bromide (TBAB), 4-dimethyl amino pyridine (DMAP), dimethyl formamide (DMF) (anhydrous), 1,4-dioxane, piperidine, 3,3′,5,5′-Tetramethylbenzidine (TMB), and streptavidin-HRP conjugate were obtained from Sigma-Aldrich (St. Louis, MO, USA). Ethylene glycol diglycidyl ether (EGDE) was obtained from TCI (Tokyo, Japan). Protease inhibitor and Live and dead staining kit were obtained from ThermoScientific (Waltham, MA, USA).

Kim S., Jwa Y., Hong J, & Kim K. (2022). Inhibition of Colon Cancer Recurrence via Exogenous TRAIL Delivery Using Gel-like Coacervate Microdroplets. Gels, 8(7), 427.

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Synthesis and Characterization of Fluorescent Polymeric Nanoparticles

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1,4-dioxane, citric acid (CA), dimethyl itaconate (DMI), fluorescein isothiocyanate-dextran (FITC-dextran, MW: 2,000,000), polysucrose 70-fluorescein isothiocyanate conjugate (FITC-Ficoll 70), maleic anhydride (MA), 1,8-octanediol (OD), triethylene citrate (TEC), 4-methoxyphenol (MeHQ), Pluronic F127, stannous octanoate (SnOct), rhodamine B were all purchased from Sigma Aldrich (Oakville, ON). chloroform (used in post-synthesis cleaning) and methanol were purchased from BioShop Canada Inc. (Burlington, ON). Deionized water (DIW) was generated using a Thermo Scientific Barnstead NANOpure water purification system.

Liu C., Campbell S.B., Li J., Bannerman D., Pascual-Gil S., Kieda J., Wu Q., Herman P.R, & Radisic M. (2022). High throughput omnidirectional printing of tubular microstructures from elastomeric polymers. Advanced healthcare materials, 11(23), e2201346.

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Lignin-Based Vitrimers Preparation

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All lignin-based vitrimers
prepared in this
work were prepared from BioPiva 100 pine kraft lignin (SKL) (UPM,
Finland), previously characterized.^{50 (link)} Poly(ethylene
glycol) divinyl ether (PDV, M_n = 250 g/mol)
and 1,4-dioxane (99.9%), isopropanol, tetrahydrofuran, acetic acid
(99%), guaiacol, and butyl vinyl ether were purchased from Sigma-Aldrich
and used as received. Aluminum sheets (type 6061) and nontreated birch
wood sheets were used as substrates for the lap shear test.

Moreno A., Morsali M, & Sipponen M.H. (2021). Catalyst-Free Synthesis of Lignin Vitrimers with Tunable Mechanical Properties: Circular Polymers and Recoverable Adhesives. ACS Applied Materials & Interfaces, 13(48), 57952-57961.

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Synthesis of Iodinated Organic Compounds

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TFPPY and TPDA were supplied by Jilin Chinese Academy of Sciences, Yanshen Technology Co. Ltd. (Changchun, China), and Shanghai Maclean Biochemical Technology Co. Ltd. (Shanghai, China); 1,4-Dioxane, acetic acid, mesitylene, MeOH, DMF, ethanol, THF, CYH, n-hexane, and acetone were supplied by Sigma-Aldrich and Aladdin (Shanghai, China). Iodine (99.8%) ¹²⁷I was purchased from Anhui Zesheng Technology Co., Ltd. (Anhui, China), which is non-radiologic instead of radiologic iodine due to having the same physical and chemical properties. Other chemical reagents were commercially available. Unless otherwise indicated, all the reagents were used without further purification.

Wang C., Jiang S., Ma W., Liu Z., Liu L., Zou Y., Xu B, & Tian W. (2023). Polymorphic Covalent Organic Frameworks: Molecularly Defined Pore Structures and Iodine Adsorption Property. Molecules, 28(1), 449.

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Synthesis and Characterization of EtP5 and EtP6

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p-Diethoxybenzene was purchased from JK Chemicals and used as received. All other chemicals, including tetrahydrofuran (THF) and 1,4-dioxane, were purchased from Sigma-Aldrich and used as received. EtP5 and EtP6 were synthesized as described previously [18 (link)]. Desolvated crystalline EtP5 (EtP5α) was recrystallized from acetone and dried under vacuum at 100°C overnight. Desolvated crystalline EtP6 (EtP6β) was recrystallized from acetone and dried under vacuum at 140°C overnight.

Zhou Y., Jie K., Zhao R., Li E, & Huang F. (2019). Cyclic Ether Contaminant Removal from Water Using Nonporous Adaptive Pillararene Crystals via Host-Guest Complexation at the Solid-Solution Interface. Research, 2019, 5406365.

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