Advance pet scanner

Manufactured by GE Healthcare

Sourced in United States

The Advance PET scanner is a medical imaging device designed to produce high-quality images of the body's internal structures and functions. It uses a radioactive tracer substance and advanced detection technology to capture detailed information about the body's metabolic and physiological processes.

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Lab products found in correlation

Gold 3 hermes hybrid viewer, by Hermes Medical Solutions (3 mentions) Fastlab, by GE Healthcare (1 mentions) Matlab 7, by MathWorks (1 mentions) Ge discovery ste pet ct scanner, by GE Healthcare (1 mentions)

Close spelling variants of this product

Advance NXi PET scanner GE Advance PET scanner Advance PET Advance scanner Scanners

11 protocols using advance pet scanner

Resting State 15O-H2O PET Scans

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Resting state ¹⁵O-H₂O scans were acquired on a GE Advance PET scanner in 3D mode. Images were obtained for 60 seconds once the total radioactivity counts in brain reached threshold levels, as described previously(25 (link)). A transmission scan in 2D mode utilizing a Ge-68 rotating source was used for attenuation correction. ¹⁵O-H₂O scans were performed after the transmission scan and before the ¹¹C-PiB-PET scan with 10 minutes between scans.
Using Statistical Parametric Mapping (SPM5; Wellcome Department of Imaging Neuroscience, London, England), ¹⁵O-H₂O PET scans were spatially normalized into standard stereotaxic space and smoothed using a Gaussian kernel to a full width at half maximum of 10, 10, and 10 mm in the x, y, and z planes. To control for variability in global flow, rCBF values at each voxel were ratio-adjusted to the mean global flow and scaled to 50 ml/100g/min for each image.

Sojkova J., Goh J., Bilgel M., Landman B., Yang X., Zhou Y., An Y., Beason-Held L.L., Kraut M.A., Wong D.F, & Resnick S.M. (2015). Voxel-wise relationships between distribution volume ratio and cerebral blood flow: implications for analysis of β-amyloid images. Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 56(7), 1042-1047.

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Automated [18F]FDG PET Imaging Protocol

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[¹⁸F]FDG was prepared using a fully automated platform (FASTlab^®, GE Healthcare) according to Hamacher et al.52 (link). PET scans were performed using a GE Advance PET Scanner with a spatial resolution of 4.36 mm full-width at half-maximum 1 cm next to the center of the field of view (matrix = 128 × 128, 35 slices, voxel size = 3.125 × 3.125 × 4.25 mm). FDG was injected intravenously at a mean dose of 3.54 ± 0.86 MBq/kg body weight. For attenuation correction a 5 min transmission scan was carried out with retractable ⁶⁸Ge rod sources. The emission measurement was done in static 3D mode, which started 30 min after injection and lasted 10 minutes. Imaging procedures were carried out under resting and awake conditions and carefully controlled for ictal events. To minimize head movements, patient’s head was placed in a polyurethane head mould and straps were placed around the chin and the forehead.

Vanicek T., Hahn A., Traub-Weidinger T., Hilger E., Spies M., Wadsak W., Lanzenberger R., Pataraia E, & Asenbaum-Nan S. (2016). Insights into Intrinsic Brain Networks based on Graph Theory and PET in right- compared to left-sided Temporal Lobe Epilepsy. Scientific Reports, 6, 28513.

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Dynamic [11C]PiB PET Imaging Protocol

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[¹¹C]PiB was produced with a radiochemical purity higher than 95% and a specific activity higher than 150 GBq/μmol. The radiotracer was injected as a bolus (median = 545 MBq, interquartile range = 465 to 576 MBq) through an antecubital venous catheter. A 15‐minute transmission scan using rotating Ge rod sources was applied to correct for photon attenuation previous to the PET scan. After that, dynamic [¹¹C]PiB PET images were acquired in three‐dimensional (3D) mode on a GE Advance PET scanner 90 minutes post‐injection. Fifty‐eight frames were acquired (18 × 5 seconds, 6 × 15 seconds, 10 × 30 seconds, 7 × 1 minutes, 4 × 2.5 minutes, and 13 × 5 minutes). Sinogram data for each frame were reconstructed into a 128 × 128 × 35 image array with a voxel size of 2.34 × 2.34 × 4.25 mm³ using the PROMIS 3D filtered back projection algorithm.²⁷ Random coincidences, normalization, attenuation, dead time, scatter, and sensitivity were corrected.

Padilla C., Montal V., Walpert M.J., Hong Y.T., Fryer T.D., Coles J.P., Aigbirhio F.I., Hartley S.L., Cohen A.D., Tudorascu D.L., Christian B.T., Handen B.L., Klunk W.E., Holland A.J, & Zaman S.H. (2022). Cortical atrophy and amyloid and tau deposition in Down syndrome: A longitudinal study. Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring, 14(1), e12288.

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FDG-PET Imaging Protocol for Alzheimer's Disease

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FDG-PET images were acquired for 30 min after an intravenous injection of 4.8 MBq/kg FDG using a General Electric Advance PET scanner. Participants stayed in a dimly lit room with their eyes closed. The in-plane and axial resolution was 4.9 × 3.9 mm full-width at half maximum (FWHM).
PET images were analyzed using SPM8 (Wellcome Department of Cognitive Neurology, Institute of Neurology, London, UK) (Friston et al., 1995 (link)) in MATLAB 7.10.0 (R2010a) (MathWorks Inc., Sherborn, MA). PET data were initially preprocessed. First, all PET images were spatially normalized into the Montreal Neurological Institute (MNI) template (MNI, McGill University, Montreal, Canada) to minimize inter-subject structural variability. Second, smoothing was performed by convolution using an isotropic Gaussian kernel with a 16-mm FWHM. Third, PET images went through one more normalization step to adjust for FDG intensity. Each voxel was normalized by the mean intensity of the cerebellum, which is known to be the least affected region in AD. The cerebellar areas were chosen using the Automated Anatomical Labeling (AAL) template.

Chung J., Yoo K., Kim E., Na D.L, & Jeong Y. (2016). Glucose Metabolic Brain Networks in Early-Onset vs. Late-Onset Alzheimer's Disease. Frontiers in Aging Neuroscience, 8, 159.

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Multimodal Imaging of Neuroendocrine Tumors

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This was a 2-year prospective study conducted at a tertiary center. All the referred patients with proven/suspected neuroblastoma, pheochromocytoma, and medullary carcinoma of thyroid were included irrespective of age and sex. Pregnant/lactating women, patients with uncontrolled diabetes mellitus, and patients taking any drug that can interfere with the tumoral uptake of MIBG were excluded from this study.
The patients underwent whole-body FDG-PET (using dedicated GE Advance PET scanner, USA) and ¹³¹I-MIBG diagnostic studies (using a dual-head large field of view Gamma Camera-Siemens E-Cam, Germany) sequentially; both were performed following standard preparatory requisites and accepted protocols.
Two experienced nuclear medicine physicians reviewed all the scans, and data were analyzed by the following criteria: (a) Qualitative: The number, visual intensity, and pattern of uptake in FDG and ¹³¹I-MIBG. The visual intensity of tumoral FDG and ¹³¹I-MIBG concentrations was further graded as low/I, moderate/II, and intense/III as per uptake was less, equal, or more than the normal physiological uptake of the liver. (b) Semiquantitative: The standardized uptake values (SUVs) were used for the lesions detected in FDG PET. The mean maximum standardized uptake value (SUV_max) values were calculated in the form of mean ± standard deviation.

Kundu S., Kand P, & Basu S. (2017). Comparative evaluation of iodine-131 metaiodobenzylguanidine and 18-fluorodeoxyglucose positron emission tomography in assessing neural crest tumors: Will they play a complementary role?. South Asian Journal of Cancer, 6(1), 31-34.

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Dynamic PiB PET Imaging Protocol

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Dynamic ¹¹C-labeled Pittsburgh compound B (PiB) PET scans were obtained on a GE Advance PET scanner in 3D mode, acquired over 70 minutes immediately following an intravenous bolus injection of ¹¹C-PiB. The PiB PET scans were processed using a method described in detail previously (Bilgel et al., 2018 (link); Walker et al., 2020 (link)). Briefly, the anatomical label image was transformed from MRI to PET space and the PET PiB distribution volume ratio (DVR) image was generated using cerebellar gray matter as the reference region. Mean cortical DVR (cDVR) was calculated by averaging DVR values across cortical regions, using parcellation maps generated by MRICloud (Walker et al., 2020 (link)). PiB positivity was defined as a mean cDVR threshold of 1.06 based on two-class Gaussian mixture modeling (Bilgel et al., 2016 (link)).

Pettigrew C., Soldan A., Brichko R., Zhu Y., Wang M.C., Kutten K., Bilgel M., Mori S., Miller M.I, & Albert M. (2021). Computerized paired associate learning performance and imaging biomarkers in older adults without dementia. Brain imaging and behavior, 16(2), 921-929.

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MET PET Imaging of Brain Tumors

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MET PET was performed using a dedicated full-ring GE Advance PET scanner (General Electric Medical Systems, field of view: 14.875 cm, 35 slices per PET examination with a slice thickness of 4.25 mm). Image acquisition started 20 min after intravenous application of ~740 MBq MET (produced in-house with a radiochemical purity of >97%). Data reconstruction was performed by filtered back projection using a Hanning filter with a cutoff value of 6.2 mm and a 128 × 128 matrix. Image evaluation was performed by 2 experienced nuclear medicine physicians using Hermes software (Gold 3 Hermes Hybrid Viewer, Hermes Medical Solutions, Stockholm, Sweden) manually drawing volumes of interest containing the highest tracer uptake in the tumor and in the contralateral hemisphere for calculating the Tumor/Normal cerebrum (T/N) ratio. Further details see also Poetsch et al. [22 (link)].

Traub-Weidinger T., Poetsch N., Woehrer A., Klebermass E.M., Bachnik T., Preusser M., Mischkulnig M., Kiesel B., Widhalm G., Mitterhauser M., Hacker M, & Koperek O. (2021). PSMA Expression in 122 Treatment Naive Glioma Patients Related to Tumor Metabolism in 11C-Methionine PET and Survival. Journal of Personalized Medicine, 11(7), 624.

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18F-FDG-PET Brain Imaging Protocol

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18F-FDG-PET scans were acquired using a General Electric Advance PET Scanner. Subjects fasted for eight hours prior to the scan. Subjects were given an intravenous injection of 5 millicuries of 18F-FDG. A transmission scan was used to correct the emission data. At the end of the 40-minute uptake period, the emission (PET) scan was performed (15 minutes per set of 35 brain slices).

Silverman H.E., Gazes Y., Barker M.S., Manoochehri M., Goldman J.S., Wassermann E.M., Tierney M.C., Cosentino S., Grafman J, & Huey E.D. (2020). Frontal pole hypometabolism linked to reduced prosocial sexual behaviors in frontotemporal dementia and corticobasal syndrome. Journal of Alzheimer's disease : JAD, 77(2), 821-830.

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Radioligand fPET Imaging with MID Task

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The radioligand was freshly prepared every day by Iason GmbH or BSM Diagnostica GmbH. One hour before start of the fPET measurement, each participant received 150 mg carbidopa p.o. to block peripheral metabolism of the radioligand by aromatic amino acid decarboxylase.^{37 (link)} fPET imaging was carried out using an Advance PET scanner (GE Healthcare). The radioligand 6-[¹⁸F]FDOPA was administered in a bolus + constant infusion protocol (ratio 20:80) similar to previously described procedures^{28 (link),29 (link)} (see supplement). During the scan the MID task was carried out at 10 (except for the PoC experiments), 20, 30 and 40 min after start of the radioligand application, each lasting for 5 min. Otherwise, a crosshair was presented and subjects were instructed to keep their eyes open and avoid focusing on anything specific (in particular not the task).

Hahn A., Reed M.B., Pichler V., Michenthaler P., Rischka L., Godbersen G.M., Wadsak W., Hacker M, & Lanzenberger R. (2021). Functional dynamics of dopamine synthesis during monetary reward and punishment processing. Journal of Cerebral Blood Flow & Metabolism, 41(11), 2973-2985.

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PET Imaging of Amyloid-β Deposition

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The dynamic ¹¹C-labeled Pittsburgh compound B tracer PET scans were performed on an Advance PET scanner (GE Healthcare, Milwaukee, Wis), and distribution volume ratio images were calculated in the native space of each PET image (26 (link),27 (link)). Mean distribution volume ratio in each selected ROI was quantified and a global index of cortical distribution volume ratio value greater than a threshold of 1.06 was considered positive for Pittsburgh compound B (or positive for amyloid-β; Appendix E7 [online]).

Chen L., Soldan A., Oishi K., Faria A., Zhu Y., Albert M., van Zijl P.C, & Li X. (2020). Quantitative Susceptibility Mapping of Brain Iron and β-Amyloid in MRI and PET Relating to Cognitive Performance in Cognitively Normal Older Adults. Radiology, 298(2), 353-362.

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