Pan keratin c11

Manufactured by BioLegend

Pan-keratin (C11) is a broad-spectrum anti-keratin antibody that binds to multiple keratin subtypes, including keratins 4, 5, 6, 8, 10, 13, and 18. This antibody is commonly used in immunohistochemistry and Western blotting applications to detect the presence and distribution of keratin proteins in various cell and tissue types.

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Lab products found in correlation

Hyperion imaging cytof system, by Standard BioTools (2 mentions) Bdca2 polyclonal, by R&D Systems (2 mentions) Cd56 123c3, by Thermo Fisher Scientific (2 mentions) Epr6855, by Standard BioTools (1 mentions) Hla dr ln3, by BioLegend (1 mentions) Cd11c ep1347y, by Abcam (1 mentions)

2 protocols using pan keratin c11

Phenotypic Profiling of Cutaneous Lupus

Cited 1 time

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Formalin-fixed, paraffin-embedded (FFPE) skin biopsy tissue sections from lesional skin of patients with ACLE, SCLE, or DLE were analyzed using the Hyperion imaging CyTOF system (Fluidigm) as previously described (24 (link)) with modifications of the antibody panel. Specifically, metal-tagged antibodies including pan-keratin (C11, Biolegend), BDCA2 (Polyclonal, R&D Systems), CD56 (123C3, ThermoFisher Scientific), HLA-DR (LN3, Biolegend), CD11c (EP1347Y, Abcam), and CD4 (EPR6855, Fluidigm) were added in this study.

Abernathy-Close L., Lazar S., Stannard J., Tsoi L.C., Eddy S., Rizvi S.M., Yee C.M., Myers E.M., Namas R., Lowe L., Reed T.J., Wen F., Gudjonsson J.E., Kahlenberg J.M, & Berthier C.C. (2021). B Cell Signatures Distinguish Cutaneous Lupus Erythematosus Subtypes and the Presence of Systemic Disease Activity. Frontiers in Immunology, 12, 775353.

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Multiparametric Profiling of SCLE and DLE Skin

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Formalin-fixed, paraffin-embedded (FFPE) skin biopsy tissue sections from lesional skin of patients with SCLE or DLE were analyzed using the Hyperion imaging CyTOF system (Fluidigm) as previously described (34 ) with modifications of the antibody panel. Specifically, metal-tagged antibodies including pan-keratin (C11, Biolegend), BDCA2 (Polyclonal, R&D Systems), CD56 (123C3, ThermoFisher Scientific), HLA-DR (LN3, Biolegend), CD11c (EP1347Y, Abcam), and CD4 (EPR6855, Fluidigm) were added in this study. Markers used to annotate each cell type are listed in Table S3.

Billi A.C., Ma F., Plazyo O., Gharaee-Kermani M., Wasikowski R., Hile G.A., Xing X., Yee C.M., Rizvi S.M., Maz M.P., Berthier C.C., Wen F., Tsoi L.C., Pellegrini M., Modlin R.L., Gudjonsson J.E, & Kahlenberg J.M. (2022). Non-lesional lupus skin contributes to inflammatory education of myeloid cells and primes for cutaneous inflammation. Science translational medicine, 14(642), eabn2263.

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