Eclipse v 10

Manufactured by Agilent Technologies

Sourced in United States

The Eclipse V.10 is a versatile lab equipment product from Agilent Technologies. It is designed to perform a variety of analytical and measurement tasks in a laboratory setting. The core function of the Eclipse V.10 is to provide reliable and accurate data collection and analysis capabilities.

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Eclipse 10.0 (7 citations)

2 protocols using eclipse v 10

Predicting the Need for Breath-Hold in Breast Radiotherapy

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For the purpose of this study only free-breathing images were used to predict the need of BH technique by analyzing possible predictors. Breast, lungs and heart were contoured according to the RTOG guidelines [8 ] and left anterior descending coronary artery (LAD) was delineated following the heart atlas described by Feng et al [9 (link)]. The left breast was considered the clinical target volume (CTV) and the planning target volume (PTV) was generated by isotropically expanding the CTV contour by 7 mm. Radiation plans were obtained with tangential fields and 6 MV photons in Eclipse V.10 (Varian, Palo Alto USA). Segmented fields were also used when necessary to reduce dose heterogeneity. The dose prescription was 50 Gy and the institutional planning goals included a minimum PTV dose coverage of 47.5 Gy and a maximum point dose of 107% of the prescription dose. Heart and lung constraints followed the QUANTEC [10 (link)] definition. Dose to LAD was not taken into consideration during planning.

Mendez L.C., Louie A.V., Moreno C., Wronski M., Warner A., Leung E., Sakuraba R., Helito J.K., Rezende A., Carvalho I.T, & Weltman E. (2018). Evaluation of a new predictor of heart and left anterior descending artery dose in patients treated with adjuvant radiotherapy to the left breast. Radiation Oncology (London, England), 13, 124.

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Validation of pDVH-Guided Adaptive Radiotherapy

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Definitive validation of pDVH predictions can only be accomplished by direct re-planning. For samples of this size it is not practical to manually re-plan every patient, so a subset was selected for re-plan validation. Using the pDVH_0126,top10% model, we selected the 10 presumed “high-quality” plans (lowest excess risk), the 10 presumed “low-quality” plans (highest excess risk), and 10 plans selected at random, collectively representing 13.7%(30/219) of the cohort.
All re-plans employed seven static fields, 15MV photons, and were optimized in a commercial planning system (Varian Eclipse v10). Re-planning guidelines were:

Maintain PTV volume receiving prescription dose (V100%)

PTV high dose not to exceed minor deviation levels (D2%<110%)

Bladder DVH maintained/improved

With pDVH_0126,top10% as guidance, improve rectal sparing as much as possible

In addition to comparisons between clinical DVHs, re-plan DVHs, and pDVHs, the 30 re-plans’ rectal NTCPs were compared to model-predicted NTCPs to validate excess risk predictions.

Moore K.L., Schmidt R., Moiseenko V., Olsen L.A., Tan J., Xiao Y., Galvin J., Pugh S., Seider M.J., Dicker A.P., Bosch W., Michalski J, & Mutic S. (2015). Quantifying unnecessary normal tissue complication risks due to suboptimal planning: a secondary study on RTOG0126. International journal of radiation oncology, biology, physics, 92(2), 228-235.

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