Dotarem

Manufactured by Bayer

Sourced in Germany

Dotarem is a gadolinium-based contrast agent used in magnetic resonance imaging (MRI) procedures. It enhances the visibility of internal body structures during the imaging process.

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Lab products found in correlation

Multihance, by Bayer (1 mentions) Espree, by Siemens (1 mentions) Gadavist, by Bayer (1 mentions) Bovine fetal serum, by Thermo Fisher Scientific (1 mentions) Thiazolyl blue tetrazolium bromide, by Merck Group (1 mentions) Dulbecco modified eagle medium (dmem), by Thermo Fisher Scientific (1 mentions) Rpmi 1640, by Thermo Fisher Scientific (1 mentions) Penicillin streptomycin, by Merck Group (1 mentions)

3 protocols using dotarem

4D-flow MRI of Thoracic Aorta

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All subjects underwent 4D-flow MRI with full volumetric coverage of the thoracic aorta (sagittal-oblique 3D volume) using either 1.5T (N = 1053; Aera, Avanto, or Espree; Siemens Healthineers, Erlangen, Germany) or 3T MRI systems (N = 140; Skyra; Siemens Healthineers). The 4D-flow MRI pulse sequence parameters were as follows: spatial resolution = 1.2–3.1 × 1.2–3.1 × 1.2–5.0 mm³, temporal resolution = 32.8–44.8 ms, velocity sensitivity (venc) = 80–500 cm/s, FOV = 124–406 × 180–500 × 38–176 mm³, TE = 2.1–3.0 ms, TR = 4.1–5.7 ms, and flip angle = 7°−25°. Data for all subjects were acquired during free-breathing with respiratory navigator gating and either prospective (N = 1172) or retrospective (N = 21) electrocardiographic gating. For N = 1064 subjects, a contrast agent (either Gadavist, Magavist, Multihance, dotarem, or Ablavar [Bayer Healthcare, Berlin, Germany] or Feraheme [Amag Pharmaceuticals, Waltham, MA]) was administered before the 4D-flow scan acquisition as standard-of-care protocol.

Berhane H., Scott M., Elbaz M., Jarvis K., McCarthy P., Carr J., Malaisrie C., Avery R., Barker A.J., Robinson J.D., Rigsby C.K, & Markl M. (2020). Fully automated 3D aortic segmentation of 4D flow MRI for hemodynamic analysis using deep learning. Magnetic resonance in medicine, 84(4), 2204-2218.

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Cytotoxicity Evaluation of Gd-DOTA in Cell Lines

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Sigma-Aldrich Co. provided the following ingredients: KMnO 4 , NaOH, MTX, Itaconic Acid (IA), and medium formulations for MCF-10A, MCF7, and 4T 1 cells (USA). The supplier of Gd-DOTA (Dotarem®) was Bayer Health Care Pharmaceuticals Inc. (Montville, NJ, USA). Merck KGaA was used to purchase more supplies (Darmstadt, Germany). The National Cell Bank of the Pasteur Institute in Iran provided the breast normal (MCF-10A), MCF7 (malignant tumors of the mouse pulmonary system), and 4T 1 (epithelial breast cancer) cell lines (IPI). Gibco and BRL provided the DMEM, RPMI 1640, and bovine fetal serum (FBS). Sigma-Aldrich provided penicillin/streptomycin and thiazolyl blue tetrazolium bromide (98%, MTT) (St. Louis, MO, USA). None of the compounds were further puri ed before usage.

Ziyaee S., Malekzadeh R., Ghorbani M., Nasiri Motlagh B., Asghariazar V, & Mortezazadeh T. (2023). Preparation of MnO₂@poly-(DMAEMA-co-IA)-conjugated methotrexate nano-complex for MRI and radiotherapy of breast cancer application. Magma (New York, N.Y.), 36(5).

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Multiparametric MRI Prostate Imaging Protocol

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The patients underwent an mpMRI of the pelvis with and without contrast protocol at our institution using a three Tesla scanner (Trio; Siemens, Erlangen, Germany). The protocol consisted of axial T1‐weighted (T1WI) and high‐resolution T2WI with more than two planes of multiplane (axial, sagittal, or coronal) and without fat suppression. Diffusion Weighted Imaging (DWI) was performed during free breathing with axial plane water‐excited fat‐suppressed single‐shot spin echo‐planar sequence. Dynamic Contrast Enhanced (DCE) MRI was done using T1‐weighted fat‐suppressed sequences before and after IV injection of contrast (DOTAREM, Bayer Pharma, Germany) at a dose of 0.1 mm/kg at a rate of 2 mL/s. Dynamic images were obtained at 20 s (arterial phase), followed by 70 s (venous phase), and then delayed phase at 3 and 10 min. The MRI sequence parameters for T2WI and DWI are given in Table 1. Two fellowship‐trained radiologists, blinded to biopsy results, reviewed the mpMRI images in consensus. They segmented a total of 18 lesions on each slice of the T2WI and ADC images using itk‐SNAP 3.8.0 software.
¹⁶ (link) For each lesion contouring, they also segmented a control region of interest (total 18) of the approximately same size and shape on the contralateral side of the prostate gland which was considered as healthy in this study.

Gumus K.Z., Contreras S.S., Al‐Toubat M., Harmon I., Hernandez M., Ozdemir S., Kumar S., Yuruk N., Mete M., Balaji K.C., Bandyk M, & Gopireddy D.R. (2024). MRI‐based radiomic features for identifying recurrent prostate cancer after proton radiation therapy. Journal of Applied Clinical Medical Physics, 25(3), e14293.

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