Lisuride

Manufactured by Merck Group

Lisuride is a laboratory equipment product. It is used as a serotonin receptor agonist. The core function of Lisuride is to serve as a research tool for studying serotonin receptor activity in a laboratory setting.

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Lab products found in correlation

N n dimethyllacetamide, by Merck Group (2 mentions) 2 hydroxypropoyl β cyclodextrin, by Merck Group (2 mentions) Fluoxetine, by Merck Group (1 mentions) Mdl100907, by Bio-Techne (1 mentions) Raclopride, by Bio-Techne (1 mentions) Reserpine, by Merck Group (1 mentions) Fluoxetine hcl, by Merck Group (1 mentions) Gr127935, by Merck Group (1 mentions) Sch23390, by Merck Group (1 mentions) Sch23390, by Bio-Techne (1 mentions) Clozapine, by Bio-Techne (1 mentions)

2 protocols using lisuride

Pharmacological Intervention Evaluation

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The drugs consisted of lisuride (Sigma-Aldrich, St Louis, MO), fluoxetine (Sigma-Aldrich), MDL 100907, and raclopride (Biotechne Corporation, Minneapolis, MN). The vehicle consisted of N,N-dimethyllacetamide (final volume 0.5%; Sigma-Aldrich) and it was brought to volume with 5% 2-hydroxypropoyl-β-cyclodextrin (Sigma-Aldrich) in water (Mediatech Inc., Manassas, VA). All drugs were injected (i.p.) in a 5 ml/kg volume.

Pogorelov V.M., Rodriguiz R.M., Roth B.L, & Wetsel W.C. (2023). The G protein biased serotonin 5-HT 2A receptor agonist lisuride exerts anti-depressant drug-like activities in mice. bioRxiv.

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Pharmacological Agents and Solvent Preparations

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The drugs consisted of lisuride maleate (#4052), clozapine (#0444), SCH23390 (#0925), GR127935 (#1477; Bio-Techne Corporation, Minneapolis, MN), LSD-tartrate (NIDA Drug Supply Program, Bethesda, MD), fluoxetine HCl (#F132) and reserpine (#R0875; Sigma-Aldrich, St. Louis, MO). The vehicle for lisuride, LSD, MDL, reserpine, SCH23390, and GR127935 consisted of N,N-dimethyllacetamide (final volume 0.5%; Sigma-Aldrich) and it was brought to volume with 5% 2-hydroxypropoyl-β-cyclodextrin (Sigma-Aldrich) in sterile water (Mediatech Inc., Manassas, VA). clozapine was solubilized with glacial acetic acid (0.05% final) and was brought to volume with 5% 2-hydroxypropyl-β-cyclodextrin in sterile water. Fluoxetine was solubilized in sterile water. All drugs were injected (i.p.) in a 5 ml/kg volume.

Pogorelov V.M., Rodriguiz R.M., Roth B.L, & Wetsel W.C. (2023). The G protein biased serotonin 5-HT2A receptor agonist lisuride exerts anti-depressant drug-like activities in mice. Frontiers in Molecular Biosciences, 10, 1233743.

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