Calcium chloride hexahydrate

Manufactured by Avantor

Sourced in United Kingdom

Calcium chloride hexahydrate is a chemical compound with the formula CaCl2·6H2O. It is a crystalline solid that is highly soluble in water. Calcium chloride hexahydrate is commonly used as a desiccant, a freezing point depressant, and an electrolyte.

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Lab products found in correlation

Dipotassium hydrogen phosphate, by Thermo Fisher Scientific (4 mentions) Sodium chloride (nacl), by Thermo Fisher Scientific (4 mentions) Resazurin, by Merck Group (4 mentions) Vitamin k, by Merck Group (4 mentions) L cysteine hcl, by Merck Group (4 mentions) Magnesium sulphate heptahydrate, by Avantor (4 mentions) Sodium bicarbonate, by Merck Group (4 mentions) Haemin, by Merck Group (3 mentions) Nonidet p 40, by Merck Group (2 mentions) Phosphate buffer saline (pbs), by Merck Group (2 mentions) Trifluoroacetic acid, by Merck Group (2 mentions) Boric acid, by Merck Group (2 mentions) Fluorescamine, by Merck Group (2 mentions) Protease fluorescent detection kit, by Merck Group (1 mentions) 5 asa, by Merck Group (1 mentions) 5 ala hydrochloride, by Merck Group (1 mentions) Tween 80, by Merck Group (1 mentions) Dextran sulfate sodium (dss), by MP Biomedicals (1 mentions) Peptone water, by Thermo Fisher Scientific (1 mentions) Yeast extract, by Thermo Fisher Scientific (1 mentions)

Close spelling variants of this product

Calcium chloride (32 citations)

4 protocols using calcium chloride hexahydrate

Preparation and Characterization of In Vitro Intestinal Models

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5-ALA hydrochloride, 5-ASA, haemin, L-cysteine HCl, vitamin K, and resazurin were obtained from Sigma Aldrich, Gillingham, UK. SFC was provided by Neopharma Japan. Ciclosporin was obtained from Cayman Chemical, Ann Arbor, Michigan, USA. Trifluoroacetic acid, tween 80, and sodium bicarbonate were obtained from Sigma Aldrich, UK. Sodium chloride and dipotassium hydrogen phosphate were obtained from Fisher Chemical, Loughborough, UK. Magnesium sulphate heptahydrate and calcium chloride hexahydrate were obtained from VWR, Poole, UK. Bile salts were from Fluka Analytical, Buchs, Switzerland. Boric acid, phosphate buffer saline, Nonidet P-40, and fluorescamine were obtained from Sigma Aldrich, UK. DSS was obtained from MP Biomedicals, Santa Ana, CA, USA. A protease fluorescent detection kit was purchased from Sigma-Aldrich, MI, USA. All other chemicals used were of high-performance liquid chromatography (HPLC)-grade and were used as received.

Yadav V., Mai Y., McCoubrey L.E., Wada Y., Tomioka M., Kawata S., Charde S, & Basit A.W. (2021). 5-Aminolevulinic Acid as a Novel Therapeutic for Inflammatory Bowel Disease. Biomedicines, 9(5), 578.

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Microbial Growth Media Optimization

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Progesterone, MPA and LNG were purchased from Sigma Aldrich, Dorset, UK. Peptone water and yeast extract were obtained from Oxoid Limited (Basingstoke, UK). Sodium chloride and dipotassium hydrogen phosphate were obtained from Fisher Chemical (Loughborough, UK). Magnesium sulphate heptahydrate and calcium chloride hexahydrate were obtained from VWR (Lutterworth, UK). Sodium bicarbonate was from Sigma Aldrich, while hemin, l-cysteine HCl, vitamin K and Resazurin were obtained from Sigma Life Sciences (Dorset, UK). Bile salts and tween 80 were from Fluka Analytical and Sigma Aldrich, UK. Methanol was purchased from Fisher scientific and was of HPLC analytical grade. Water was purified using Elga reservoir water purification system. All other chemicals and solvents were of HPLC reagent grade and were used without further purification.

Coombes Z., Yadav V., E. McCoubrey L., Freire C., W. Basit A., Conlan R.S, & Gonzalez D. (2020). Progestogens Are Metabolized by the Gut Microbiota: Implications for Colonic Drug Delivery. Pharmaceutics, 12(8), 760.

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Formulation of Enteric-Coated Tablets

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Lactose monohydrate was obtained from Meggle, Wasserburg Germany. Povidone (K25) was acquired from Boai NKY Pharmaceuticals Ltd, Jiaozuo, China, and sodium starch glycolate was obtained from JRS Pharma, Rosenberg, Germany. Magnesium stearate was provided by Peter Greven GmbH & Co. KG, Bad Münstereifel, Germany. Talc was obtained from Ferdinand Kreuzter Sabamühle GmbH, Nürnberg, Germany. Eudragit ® S was purchased from Evonik, Darmstadt, Germany. Maize starch (Amylo N-400 formerly known as Eurylon 6) was purchased from Roquette, Lestrem, France. Polysorbate 80 (tween 80), butan-1-ol, sodium hydroxide were all purchased from Sigma-Aldrich, Buchs, Switzerland. Potassium dihydrogen phosphate, glyceryl monostearate (GMS) and triethyl citrate (TEC) were all purchased from VWR international LTD, Poole, UK. Trifluoroacetic acid and buffer salts used for dissolution buffers preparation were obtained from Sigma-Aldrich, UK. Sodium chloride and di-potassium hydrogen phosphate were obtained from Fisher Chemical. Magnesium sulphate heptahydrate and calcium chloride hexahydrate were obtained from VWR, UK. Sodium bicarbonate was obtained from Sigma Aldrich, UK, while haemin, L-cysteine HCl, vitamin K and resazurin were obtained from Sigma Life Sciences, UK. Bile salts were from Fluka Analytical, UK and FlukaChemika, UK.

Varum F., Freire A.C., Fadda H.M., Bravo R, & Basit A.W. (2020). A dual pH and microbiota-triggered coating (Phloral™) for fail-safe colonic drug release. International journal of pharmaceutics, 583.

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Synthesis and Characterization of Tofacitinib Citrate

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Tofacitinib citrate was synthesized at Merck & Co., Inc., Rahway, NJ, USA. Haemin, L-cysteine HCl, vitamin K, resazurin, boric acid, phosphate buffer saline, Nonidet P-40, dexamethasone, polysorbate 80, polysorbate 20, polyethylene glycol 400, fluorescamine, and sodium bicarbonate were obtained from Sigma Aldrich, Gillingham, UK. Sodium chloride and dipotassium hydrogen phosphate were obtained from Fisher Chemical, Loughborough, UK. Magnesium sulphate heptahydrate and calcium chloride hexahydrate were obtained from VWR, Poole, UK. Bile salts were from Fluka Analytical, Buchs, Switzerland. Barium sulfate was purchased from Alfa Aesar by Thermo Fisher Scientific, Haverhill, MA, USA. Methocel^® A4C premium was purchased from Dow Chemical Company, Midland, MI, USA. All other chemicals used were of high-performance liquid chromatography (HPLC)-grade and were used as received.

Yadav V., House A., Matiz S., McCoubrey L.E., Bettano K.A., Bhave L., Wang M., Fan P., Zhou S., Woodhouse J.D., Poimenidou E., Dou L., Basit A.W., Moy L.Y., Saklatvala R., Hegde L.G, & Yu H. (2022). Ileocolonic-Targeted JAK Inhibitor: A Safer and More Effective Treatment for Inflammatory Bowel Disease. Pharmaceutics, 14(11), 2385.

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