Quantitative data presented in this study are EARL-compliant. Patients fasted at least 6 h before intravenous injection of 18F-FDG and were scanned on a Biograph TrueV system (Siemens Heathineers) from the skull base to the mid-thighs. A free-breathing CT acquisition (60 mAs, 130 kVp, pitch 1, and 6 × 2 mm collimation) was followed by a PET/CT acquisition with time per bed position of 160 and 220 s for normal weight (BMI ≤ 25 kg/m2) and overweight patients (BMI > 25 kg/m2), respectively.
PET/CT studies were planned to be performed 60 ± 5 min post-injection. Extraction of data from the PET/CT DICOM headers showed the following information: mean injected activity ± SD was 4 ± 0.1 MBq/kg. Mean delay between injection and acquisition ± SD was 59.3 ± 5.2 min on baseline and 4 ± 0.2 MBq/kg and 60.3 ± 5.0 min on interim TEP, respectively.
Raw data were reconstructed with point spread function (PSF) modeling (HD; TrueX, Siemens Heathineers), with 3 iterations and 21 subsets and no filtering. Matrix size was 168 × 168 resulting in voxels of 4.07 × 4.07 × 4 mm.