Biograph mmr 3 t scanner

Manufactured by Siemens

Sourced in Germany

The Biograph mMR 3 T scanner is a magnetic resonance imaging (MRI) system designed for medical research applications. It provides a 3 Tesla magnetic field strength and is capable of acquiring high-resolution anatomical and functional images. The system is intended for use in clinical research settings to support the advancement of medical knowledge and understanding.

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Lab products found in correlation

16 channel head coil, by Siemens (1 mentions) 12 channel head coil, by Siemens (1 mentions)

3 protocols using biograph mmr 3 t scanner

Multimodal Brain Imaging with 3T MRI

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T1-, T2-, and diffusion-weighted images were acquired with a 3.0-Tesla Siemens Biograph mMR 3 T scanner (Siemens Healthcare Sector, Germany) with a 16-channel head coil. T1-weighted structural images were acquired with the following parameters: echo time (TE) = 1.89 ms, repetition time (TR) = 1670 ms, field of view (FOV) = 250 mm, flip angle = 9°, matrix = 256 × 256, voxel size = 1.0 × 1.0 × 1.0 mm³, and 208 slices. T2-wighted images were acquired with the following parameters: 47 axial slices, slice thickness = 3 mm, TR = 5000 ms, TE = 81 ms, FOV = 220 × 220 mm2, flip angle = 124°.
Axial diffusion-weighted single-shot echo-planar images were acquired with the following parameters: TE = 92.0 ms, TR = 9500 ms, FOV = 230 mm3, voxel size = 2.0 × 2.0 × 2.0 mm³, 66 axial slices, slice gap = 0 mm, and b-factor = 1000 sec/mm2. A baseline image without diffusion volume was used as a reference image, and diffusion-weighted images were acquired from 67 different directions. All axial images were acquired parallel to the anterior-posterior commissure line.
Preprocessing steps included skull stripping and eddy -current correction using the FMRIB software Library(FSL)(Jenkinson et al., 2012 (link)). Motion correction was done by the affine alignment to the b0 image.

Byun J.I., Oh S., Sunwoo J.S., Shin J.W., Kim T.J., Jun J.S., Kim H.J., Shin W.C., Seong J.K, & Jung K.Y. (2022). White matter tract-specific microstructural disruption is associated with depressive symptoms in isolated RBD. NeuroImage : Clinical, 36, 103186.

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Cardiac Stroke Volume Measurement by MRI

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SV was measured by MRI (Biograph mMR 3-T scanner, Siemens, Erlangen, Germany) once during the BDC phase (BDC-4), twice during the HDT phase (HDT21 and HDT58), and once during the recovery phase (R + 4, see Fig. 1). The subject was placed inside the MRI machine in supine 0° position. 2D PC-MRI images (30 frames per cardiac cycle, spatial resolution 1.4 × 1.4 × 5.0 mm^{3 (link)}) were acquired during spontaneous breathing using a plane perpendicular to the centerline at a proximal site of the ascending aorta, with three-directional velocity encoding (x, y: 80 cm/s; z: 150 cm/s). SV was computed as the time integral of the flow rate in the systolic ejection period. More information concerning this protocol is given by Caiani and coworkers³¹.

Rabineau J., Hossein A., Landreani F., Haut B., Mulder E., Luchitskaya E., Tank J., Caiani E.G., van de Borne P, & Migeotte P.F. (2020). Cardiovascular adaptation to simulated microgravity and countermeasure efficacy assessed by ballistocardiography and seismocardiography. Scientific Reports, 10, 17694.

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Neuropsychological Assessment and Resting-State fMRI

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This study has been conducted at the IRCCS Synlab SDN (Naples, Italy). An expert neuropsychologist performed the neuropsychological assessment for each participant. Such an assessment included a self-report evaluation of subjective sleep quality (PSQI), an assessment of depression and anxiety, and an evaluation of verbal and visuospatial working memory performance. After the neuropsychological assessment, each participant underwent a resting-state fMRI experimental protocol. MR images were acquired using a Biograph mMR 3T scanner (Siemens Healthcare, Erlangen, Germany) and a 12-channel head coil. An ad hoc acquisition protocol was devised, which included the following structural and functional sequences: (1) 3D T1-Magnetisation Prepared Rapid Acquisition Gradient Echo (MPRAGE), voxel size 0.8 × 0.8 × 0.8 mm³, Field of View (FOV) 214 × 214 mm, TR/TE/TI = 2,400/2.25/1,000 ms, scan time 5:03; and (2) Resting-state fMRI, Echo Planar Imaging-Gradient Echo sequence (EPI-GRE), voxel-size 4 × 4 × 4 mm³, TR/TE = 1,000/21.4 ms, 350 measurements, bandwidth: 2,230 Hz, scan time 6:02.

Federico G., Alfano V., Garramone F., Mele G., Salvatore M., Aiello M, & Cavaliere C. (2022). Self-Reported Sleep Quality Across Age Modulates Resting-State Functional Connectivity in Limbic and Fronto-Temporo-Parietal Networks: An Exploratory Cross-Sectional fMRI Study. Frontiers in Aging Neuroscience, 14, 806374.

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