The native porcine dermis-based Bio-Gide® membrane (Geistlich Pharma AG, Wolhusen, Switzerland) is exclusively produced from Swiss porcine tissue and consists of collagen types I and III [35 ]. The purification process includes an intensive multi-stage chemical purification process and a final sterilization by gamma radiation [36 ]. This collagen membrane is composed of a compact, smooth layer with low porosity and a porous layer with a sponge-like three-dimensional structure. The Bio-Gide® membrane has already been investigated in many preclinical and clinical studies for its biocompatibility and its usefulness in GBR techniques [29 (link),37 (link)].
Bio gide membrane
Manufactured by Geistlich Pharma
Sourced in Switzerland
Bio-Gide® membrane is a resorbable, bilayer membrane made of porcine collagen. It is designed for use in dental and oral surgery procedures.
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Lab products found in correlation
4 protocols using bio gide membrane
1
Biocompatible Porcine Collagen Membrane
2
Melatonin and Bio-Gide® Membrane Protocol
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In this research study Melatonin synthetic hormone N-Acetyl-5methoxytryptamine, Melatonin (C13H16N2O2) (Sigma, St. Louis, Missouri, EOA), grade of purity > 98%, and a concentration of 1mM, was used, based on the research study by Dalla-Costa et al., (2020). The Geistlich Bio-Gide® membrane was used (Gide Compressed 13x25mm (Ref.: 500362 and 308013) (Geistlich Pharma do Brasil, Sao Paulo, SP, Brazil).
One nM of MLT was diluted in the culture médium and the Bio-Gide® membrane was cut into 5 mm squares.
One nM of MLT was diluted in the culture médium and the Bio-Gide® membrane was cut into 5 mm squares.
3
Anti-BMP-2 mAb Augmented Bone Regeneration
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The experimental mAb was a chimeric anti-BMP-2 mAb with cross-reactivity to BMP-4 and BMP-7. The control mAb was an isotype matched mAb specific for the KLH peptide that had no specific affinity for BMP-2 [54 (link)]. A concentration of 25 μg/ml of mAb was chosen based on the results of our previous studies [54 (link)]. Anti-BMP-2 mAb and isotype matched control mAb were immobilized on deproteinized anorganic bovine bone mineral with 10% collagen (ABBM-C; Bio-Oss Collagen®, Geistlich, Pharma AG, Wolhusen, Switzerland) as well as porcine bilayer native collagen membrane (CM; Bio-Gide® membrane, Geistlich, Pharma AG, Wolhusen, Switzerland) as previously described [54 (link)]. Briefly, the ABBM-C and CM were incubated at room temperature with mAb diluted with phosphate-buffered saline (PBS) for one hour prior to implantation into the sockets after tooth extraction. All antibody preparations were made by two of the coauthors (S.M., O.K.).
4
Comparative Analysis of Collagen-Based Membranes
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The Jason® membrane (botiss biomaterials GmbH, Zossen, Germany) is based on native collagen won from porcine pericardium. The standardized production process includes a controlled selection of the donor animal through veterinary controls. Further steps include cleaning, including wet chemical processes and lyophilization, as well as a final sterilization step using EO gas (Jason Membrane; Botiss Biomaterials, 2020).
The Ossix® Plus membrane (Datum Dental, Lod, Israel) is a ribose cross-linked collagen membrane and contains porcine collagen type I, obtained from the Achilles tendon of cattle. It is described that the membrane is initially cleaned by several “processing steps” and returned to its monomeric stage by enzymatic treatment with pepsin in order to enable a more efficient removal of potentially immunogenic telopeptides in native collagen. In addition, the cross-linking of the collagen is prepared with the help of ribose with the so-called GLYMATRIX® technology (Regedent—Ossix Plus Broschüre, 2020).
In case of the Bio-Gide® membrane (Geistlich Pharma AG, Wolhusen, Switzerland), it is stated that the precursor tissue from porcine dermis is purified by a multi-stage process that allows to remove fat and other tissue components. As a final step, the BioGide® membrane is sterilized via gamma irradiation (Geistlich BioGide®, 2020).
The Ossix® Plus membrane (Datum Dental, Lod, Israel) is a ribose cross-linked collagen membrane and contains porcine collagen type I, obtained from the Achilles tendon of cattle. It is described that the membrane is initially cleaned by several “processing steps” and returned to its monomeric stage by enzymatic treatment with pepsin in order to enable a more efficient removal of potentially immunogenic telopeptides in native collagen. In addition, the cross-linking of the collagen is prepared with the help of ribose with the so-called GLYMATRIX® technology (Regedent—Ossix Plus Broschüre, 2020).
In case of the Bio-Gide® membrane (Geistlich Pharma AG, Wolhusen, Switzerland), it is stated that the precursor tissue from porcine dermis is purified by a multi-stage process that allows to remove fat and other tissue components. As a final step, the BioGide® membrane is sterilized via gamma irradiation (Geistlich BioGide®, 2020).
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